Chathuddasie Amarasinghe

Diagram of an E. coli cell showing polysomes pushing sister chromosomes apart. Bottom heatmaps show cell-cycle-dependent changes in DNA and ribosome density distributions, and constriction formation. The top right corner shows normalized mid cell amounts from these heatmaps (integrated between the dashed horizontal lines).

Our latest work is out in PNAS!🎉
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...

#MicroSky #Microbiology #Biophysics #CellBiology

09.11.2025 02:05 — 👍 25    🔁 10    💬 1    📌 1

The role of active mRNA–ribosome dynamics and closing constriction in daughter chromosome separation in Escherichia coli | PNAS The mechanisms by which two sister chromosomes separate and partition into daughter cells in bacteria remain poorly understood. A recent theoretica...

How do bacteria separate their chromosomes without the mitotic spindle machinery?
Our new PNAS paper reveals that E. coli relies on the dynamics of mRNA–ribosome complexes, together with cell constriction, to drive daughter chromosome separation.

📄 Read more: www.pnas.org/doi/10.1073/...

06.11.2025 22:14 — 👍 4    🔁 1    💬 0    📌 1

The role of active mRNA-ribosome dynamics and closing constriction in daughter chromosome separation in Escherichia coli The mechanisms by which two sister chromosomes separate and partition into daughter cells in bacteria remain poorly understood. A recent theoretical model has proposed that out-of-equilibrium processe...

We're excited to share our new preprint exploring how active mRNA-ribosome dynamics and closing constriction shape chromosome segregation in E. coli.
www.biorxiv.org/content/10.1...

#biophysics #nucleoid

10.04.2025 21:40 — 👍 2    🔁 1    💬 0    📌 0