Jonathan VanRyzin

This project will explore how early life adversity impairs circuit-specific astrocyte-neuron interactions in the nucleus accumbens and identify the molecular mechanisms of astrocyte dysfunction that lead to addiction susceptibility

Incredibly grateful to be one of the 2025 BBRF Young Investigator Grant awardees!
Thank you to @bbrfoundation.bsky.social and to my mentors for their support along the way!

Epigenetic regulation of brain development, plasticity, and response to early-life stress Neuropsychopharmacology - Epigenetic regulation of brain development, plasticity, and response to early-life stress

Review now out in @npp-journal.bsky.social!
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq

Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala

#ThisWeekInNPP

This study explored how prenatal & postnatal THC exposure affects 🧠 development & social behavior in 🐭, highlighting an impact on microglial phagocytosis in the developing amygdala in a sex-specific & timing-dependent manner ⏲️ / @jwvanryzin.bsky.social

Huge thank you to everyone on the project!! @aidanlpham.bsky.social @kristenmontgomery.bsky.social @aemarquardt.bsky.social @pegmccarthy.bsky.social @um-mind.bsky.social

Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala

Excited to see our most recent project published in @npp-journal.bsky.social !
We show that the timing of THC exposure during development—prenatal vs. postnatal—leads to opposite effects on social behavior and microglial function in the amygdala. Timing matters!

www.nature.com/articles/s41...

Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala

Excited to announce our latest production! @jwvanryzin.bsky.social @aemarquardt.bsky.social @um-mind.bsky.social www.nature.com/articles/s41...

Happy #FluorescenceFriday !

Sharing one of my favorite images I've taken of microglia phagocytosis featuring a neuron whose DAPI is all too happy to be eaten.

Thank you!

go.bsky.app/Lyzro3M

!WELCOME!

thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.

apologies for missing many of you - please do reply to get added

and remember to repost so the newbies can find us!

In doing so, we can estimate the number of synapses that an astrocyte interacts with and determine how many of those are circuit-specific.

I've been trying something a bit different on the microscope lately. Looking at ways we can model physical interactions of astrocytes with specific neural circuits across development.

Finally made the migration!

To any new faces, I'm Jon and I'm a postdoc at UNC studying microglia, astrocytes, brain development, stress, and addiction. I'm also on the job market!