Waser Group

The review of Emma Robert on cycloaddition and annulation reactions with Donor-Acceptor cyclobutanes has now appeared in @helvchimacta.bsky.social !
doi.org/10.1002/hlca...

New from #Kineticolor:

Computer Vision Helps Experimentally Monitor Mixing Effects in Deep Eutectic Solvents

Mixing matters, and you have to monitor it over time…and beware of vessel reaction geometry!

🎥🧪 If you can see it, we can help you measure it.

pubs.acs.org/doi/10.1021/...

Biomimetic Total Synthesis of (±)-Lappaceolides A and B The first total synthesis of lappaceolides A and B is achieved in two steps by using a biomimetic vinylogous-Michael–oxa-Michael domino reaction. The domino reaction proceeds with Cs2CO3 in 1,2-DCE at...

Our two-step total synthesis of monoterpene lactones Lappaceolide A and B appears in Org. Lett. ASAPs! Kudos to our postdoc Rajanish for troubleshooting the tricky domino reaction, and to undergraduate researchers Jenna and Leevi for initial route exploration. #chemsky
pubs.acs.org/doi/10.1021/...

Early Career Research (ECR) Group Leader position (m/f/d) with the thematic focus on “Catalysis” within the Cluster of Excellence RESOLV

Please check this announcement for an early-career group leader, hosted jointly by our cluster of excellence RESOLV and the MPI Kofo. The thematic focus should be on catalysis: jobs.ruhr-uni-bochum.de/jobposting/4...

In our new paper in Chem. Sci., we show that the replacement of one oxygen by one sulfur atom in phospholipids affords phosphorothioate liposomes that penetrate cells by thiol-mediated uptake in intact form and with contributions neither from fusion nor from endocytosis.

We built a machine learning–guided workflow to optimize reaction conditions for photochemical nickel-catalyzed cysteine arylation; no specialized robots or fancy HTE plates needed!

Check it out @chemrxiv.org : chemrxiv.org/engage/chemr...

#MachineLearning #ReactionOptimization

We have just published a vacancy for a Senior/Principal Scientist Pharmaceutical Development at Roche, Basel, Switzerland: www.organic-chemistry.org/jobs/offers/... - Please check and share!

Current pump vacuo record @lcsolab.bsky.social (with attached Schlenk line)

Photoswitches beyond azobenzene: a beginner’s guide Beilstein Journal of Organic Chemistry

Learn more about photoswitches!
This review describes the synthesis, structure–property relationships, and examples of applications for seven important classes of photoswitches
doi.org/10.3762/bjoc...

Second organic seminar now at EPFL Chemistry from Prof. Christof Sparr from university of Basel | LCSO Lab Second organic seminar now at EPFL Chemistry from Prof. Christof Sparr from university of Basel

Second organic seminar at EPFL with @csparr.bsky.social
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Organic seminars back at EPFL Chemistry with Prof Robert J Phipps from Cambridge University | LCSO Lab Organic seminars back at EPFL Chemistry with Prof Robert J Phipps from Cambridge University

Organic seminars at EPFL! First Robert Phipps.
www.linkedin.com/feed/update/...

Ana I. Benítez-Mateos

Ambrox through the Looking Glass: Chemoenzymatic Synthesis and GC-Olfactometric Analysis of 15 Ambrox Stereoisomers https://doi.org/10.1002/hlca.202400016

This is ECAB member @ana-benitezmateos.bsky.social favorite @helvchimacta.bsky.social article because it shows the biocatalytic versatility of SHC enzymes in accessing nearly all stereoisomers of Ambrox, while also advancing the understanding of structure–odor relationships. doi.org/10.1002/hlca...

Generalizing Vinyl Halide Cross‐Coupling Reactions with Photoredox and Photoredox/Nickel Dual Catalysis A general strategy has been developed for predictable and robust vinyl halide cross-coupling reactions. This approach demonstrates broad applicability across seven distinct bond-forming transformatio...

Interested in vinyl halide chemistry?
Then use our new strategy to simplify your reactions!
Thanks to all involved!
@angewandtechemie.bsky.social
@indrajitghosh85.bsky.social
#ChemSky #photocatalysis #Nickel

doi.org/10.1002/anie...

The 2026 Chemistry Faculty Jobs List

The 2026 Chemistry Faculty Jobs List has 170 tenure-track positions and 19 teaching positions: docs.google.com/spreadsheets... #facultychemjobs #chemjobs #chemsky 🧪⚗️

Our new paper in Angew. Chem. introduces an enabling method to make catalysis with externally applied electric fields compatible with organic synthesis.

onlinelibrary.wiley.com/doi/10.1002/...

We felt a sense of urgency to summarize why mixing matters in synthetic organic chemistry.

Our takeaway: don’t toss those stir bars yet!
The truth is more complex than it may seem.

Read our ChemRxiv preprint: chemrxiv.org/engage/chemr...

#Chemistry #Mixing #Reproducibility

www.organic-chemistry.org/abstracts/li...
Steric and electronic tuning of oxoammonium catalysts led to complementary sets of conditions that can oxidize a broad scope of carbamates, sulfonamides, ureas, and amides into the corresponding imides.

👏 Phys.org has featured the work of our colleagues at IOCB Prague.

The team led by @pluskal-lab.org created the world’s largest database of small-molecule #massspec. See more ► doi.org/10.1038/s41592-025-02813-0

#IOCBPrague #massspec #metabolomics #drugdiscovery #NatureMethods

We have just published a short overview article explaining the concepts copper catalysys with bifunctional ligands published recently. @synlettjournal.bsky.social.

It's a short read, check it out here: www.thieme-connect.com/products/ejo...

#CHEMnitz
#copper
#NHCs

In a preprint, we report a particularly interesting substrate for biaxial halogen bonding with iodine(III)-based Lewis acids: allenes. We also introduce chiral variants which allow enantiodiscrimination of allenes via NMR:

Special organic seminar today at EPFL Chemistry with Ming Joo (MJ) Koh from NUS Singapore | LCSO Lab Special organic seminar today at EPFL Chemistry with Ming Joo (MJ) Koh from NUS Singapore

next organic seminar at EPFL with Prof. M. J. Koh @mjkoh87.bsky.social from NUS Singapore
www.linkedin.com/feed/update/...

Photochemical Thiocarbonyl Difluoride Generation Enables Azetidine Synthesis The activation of amines into thiocarbamoyl fluorides (TCarbFs) provides access to valuable nitrogen-based functionalities. However, their broader use has been hindered by the reliance on harsh reagen...

New school year, New paper !
Check out our last preprint in @chemrxiv.org on the photochemical generation of Thiocarbonyl difluoride (TCF) for Azetidine synthesis. shorturl.at/m5Wjc

llmac 2025 Conference Day 1 started with a full house 👏
Topic of today: Artificial Intelligence (AI) and digital methods
📍 You will find us in the back of the hall - Booth SCS 01
#scs #ilmac25 #ilmac #chemistry #conference #Basel #Switzerland #AI

#lcsojournalclub | LCSO Lab #LCSOJournalClub 202.1 (highlighted in picture): New fluorinated aza-peptides developed by Benoît Crousse and co-workers from Université Paris-Saclay reported in ACS Org. Inorg. Au https://lnkd.in/e4B...

Edition 202 of #LCSOJournalClub
www.linkedin.com/feed/update/...

A reaction scheme showing a generic arene structure, which is first olefinated through a nondirected C-H olefination, followed by two oxidative cleavage pathways, one giving carboxylation products the other giving formylation products.

Access SEAr-type products in typically disfavored positions! Contratulatons to Rita, @jyotirmoydey.bsky.social and Elisa showin in Org. Lett. how nondirected C-H activation and oxidative cleavage can be used to obtain challenging regioisomers in formylation and carboxylation doi.org/10.1021/acs....

Synthesis of a Functionalized Bicyclo[3.2.1]Octane: A Common Subunit to Kauranes, Grayananes, and Gibberellanes A detailed account on the synthesis of a bicyclo[3.2.1]octane scaffold, common to the kaurane, grayanane, and gibberellane diterpenoid families, is reported. Our original strategy relying on a 1,4-si...

It is said that you learn best from your failures.. Let's just say we learned a lot in this project, but in the end we managed to synthesize a common scaffold to kauranes and related diterpenoids. Very proud of Nicolas and Camil! Detailed story in @chemistryeurope.bsky.social
doi.org/10.1002/chem...

Don’t miss Timothy Noël @tnoel82.bsky.social (University of Amsterdam) giving an online @gdch.de lecture organized by the Liebig-Vereinigung.
#ChemSky

Details and registration: gdch.app/event/from-b...

📔Cover Page: Our recent work on strain-release functionalization of NAr-BCBS to access spirocyclic sultams has been featured on the cover page of the current issue of Organic Letters. Thank you @pubs.acs.org

Phosphanides are able to capture nitrous oxide (N2O, #laughinggas). Work by Alex Genoux (@alexgenouxchem.bsky.social ), Dicky Wong (@thwongax.bsky.social ), and Farzaneh Fadaei-Tirani. Now out (#openaccess ) in @chemcomm.rsc.org : pubs.rsc.org/en/content/a...
#chemsky #EPFL

#lcsojournalclub | LCSO Lab #LCSOJournalClub 201.1 (highlighted in picture) A synthesis of fluoroalkyl cyclopropenes proceeding via a cyclopropenium intermediate reported by Xiao Shen and co-workers from Wuhan University in Chem...

edition 201 of #LCSOJournalClub
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