H Ismail Lab (CBG)

Scientists have developed an ‘early warning system’ that could predict insecticide resistance in malaria mosquitoes before it emerges in the field.

Read more: lstm.ac/4q94Kmi

Take-home: ABPP can bridge genotype→phenotype gaps and complement genomic surveillance, a practical way to anticipate cross-resistance and de-risk insecticide rollout/rotation strategies. #malaria #vectorcontrol #chemoproteomics 

Key hit: carboxylesterase Coeae6g. Functional validation shows it confers resistance to pirimiphos-methyl and drives cross-resistance to malathion, bendiocarb, and permethrin

Using fluorophosphonate (FP) probes + pirimiphos-methyl oxon (PMO) competition, we mapped active serine hydrolases in a susceptible Kisumu strain, linking function to candidate resistance drivers (not just expression).

Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae - Nature Communications The evolution of insecticide resistance in the major malaria vector, Anopheles gambiae, remains an important issue in sustainable malaria control in Africa. Here, the authors present a framework for i...

New in Nature Communications: a predictive chemoproteomics workflow (competitive ABPP) to spot future insecticide resistance liabilities in Anopheles gambiae before they’re obvious in the field. doi.org/10.1038/s414...

Professor and Head of Department of Chemistry at University of Liverpool Recruiting now: Professor and Head of Department of Chemistry on jobs.ac.uk. Click for details and explore more academic job opportunities on the top job board

Liverpool is hiring for a Professor who would also be Head of Chemistry. Application deadline Jan 4th. Interviews Feb 5th. I really like it here; maybe you would, too. www.jobs.ac.uk/job/DPQ019/p...