Charlie Swanton

I am very excited that Imrans and @magnushaughey.bsky.social article in @aacrjournals.bsky.social is now online.

This was a great collaboration with @charlesswanton.bsky.social and Paul Mischel amongst many others.

A small thread will follow below.

aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery @aacrjournals.bsky.social: ecDNA–Driven Oncogene Spatial Heterogeneity & Evolution in Glioblastoma - by Imran Noorani, @magnushaughey.bsky.social, Paul Mischel, @charlesswanton.bsky.social, @benjaminwerner.bsky.social, and colleagues doi.org/10.1158/2159...

This research was led by Imran and co-first author Magnus Haughey, with senior authors Paul Mischel at @stanforddeptmed.bsky.social, @benjaminwerner.bsky.social at @qmucu.bsky.social, and @charlesswanton.bsky.social at the Crick.

Rogue DNA rings reveal earliest clues to deadly brain cancer’s growth In a new study, published today in Cancer Discovery, the eDyNAmiC team, led by Paul Mischel at Stanford University, and collaborator Charlie Swanton at the Crick, integrated genomic and imaging data f...

Research from the Cancer Grand Challenges eDNyamiC team found that rogue rings of DNA appear early in glioblastoma, a very aggressive form of brain cancer.

Co-first author Imran Noorani explains how this work makes the case for early detection of these tumours.

www.crick.ac.uk/news/2025-09...

New in @cp-cancercell.bsky.social: Drs. Krijn Dijkstra, Sergio Quezada, Emile Voest, and @charlesswanton.bsky.social
established patient-derived #organoids to study immune invasion in #LungCancer. 🫁

Article: bit.ly/4ltQPp2
Discussion: bit.ly/3GP9NaK

Subclonal immune evasion in non-small cell lung cancer
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @charlesswanton.bsky.social

Congratulations Samra - you will be an amazing director !

Tumor-Infiltrating Clonal Hematopoiesis | NEJM Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencie...

New evidence that age-related clonal hematopoiesis (CHIP) drives solid cancer progression by remodelling the tumour immune microenvironment. Out in @nejm.org
Congrats @oriolpich.bsky.social, @elsabernard.bsky.social, Maria Zagorulya, @charlesswanton.bsky.social et al.

www.nejm.org/doi/full/10....
🧪

This research was led by @oriolpich.bsky.social, Elsa Bernard and Maria Zagorulya, with corresponding authors Elli Papaemmanuil, Elsa Bernard and @charlesswanton.bsky.social. The project was supported by @cancerresearchuk.org and @uclhresearch.bsky.social.

Age-related genetic changes in the blood associated with poor cancer prognosis Researchers from the Francis Crick Institute, UCL, Gustave Roussy and Memorial Sloan Kettering Cancer Center (MSK), have discovered that expansion of mutant blood cells, a phenomenon linked to ageing,...

Researchers from the Crick, @ucl.ac.uk, @gr-research.bsky.social and @mskcancercenter.bsky.social have discovered that certain age-related genetic changes in the blood are associated with worse outcomes for cancer patients.

www.crick.ac.uk/news/2025-04...

Tumor-Infiltrating Clonal Hematopoiesis | NEJM Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencie...

Super to work with Oriol Pich, Elsa Bernard Maria Zagorulya,
@PapaemmanuilLab exploring how the age related process CHIP might impact tumour biology; incredible team. Thank you to all our funders, CRUK, Crick, BCRF, Rosetrees Trust, Mark Foundation+ Royal Society

www.nejm.org/doi/full/10....

Tumor-Infiltrating Clonal Hematopoiesis | NEJM Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencie...

Wow!!! 🤯 Amazing, @oriolpich.bsky.social, @charlesswanton.bsky.social, and team!

www.nejm.org/doi/full/10....

Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.

Are you a clinician looking for a fully-funded postdoctoral research opportunity? 🩺

Take a look at our postdoctoral career development fellowships for clinicians, and see how you can join our vibrant community of clinician scientists.

Apply by 30 April ➡️ www.crick.ac.uk/careers-and-...

@charlesswanton.bsky.social kicks off the @cancergrand.bsky.social Summit and mentions the commentaries on the impact of the original #CancerGrandChallenges teams published in the January issue of Cancer Discovery - you can read them here: aacrjournals.org/cancerdiscov...

Please share! @charlesswanton.bsky.social @isidrolauscher.bsky.social
@peterlylab.bsky.social @maitehuartelab.bsky.social @florentmouliere.bsky.social @andreaventura.bsky.social @anton-henssen.bsky.social

A huge thanks to my co-authors, especially my PI Prof. Nicholas McGranahan for guiding all of this and @charlesswanton.bsky.social who gave his support throughout. Thanks also to @genomicsengland.bsky.social , @cruk-cityoflondon.bsky.social , UCL Cancer Institute, and @crick.ac.uk

Phenomenal data and unique insights from @charlesswanton.bsky.social and colleagues. Bravo!

And a final thanks to our funders without which none of this work would have been possible: @cancerresearchuk.org, @wellcometrust.bsky.social and Rosetrees as well as most importantly all the patients & participants.

ImmuneLENS characterizes systemic immune dysregulation in aging and cancer - Nature Genetics Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating ...

🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells.

Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇

Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma - Nature Cancer Swanton and colleagues present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcino...

💫New Article

Dhruva Biswas, Nicolai J. Birkbak & @charlesswanton.bsky.social and team present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcinoma.

www.nature.com/articles/s43...

Lung cancer test better predicts survival in early stages of disease A new test, developed by researchers from UCL Cancer Institute and the Francis Crick Institute, can better predict lung cancer survival at the point of diagnosis, which could inform treatment decision...

A new test, developed by a team led by @charlesswanton.bsky.social from UCL Cancer Institute & @crick.ac.uk, can better predict lung cancer survival at the point of diagnosis and could help to inform treatment decisions
www.ucl.ac.uk/news/2025/ja...

Tumour DNA in the blood can predict lung cancer outcome Scientists from the Francis Crick Institute, UCL, UCLH and Personalis have found that a test to detect circulating tumour DNA can predict lung cancer outcome in a Cancer Research UK-funded study.

Scientists at the Crick, @ucl.ac.uk , @uclh.bsky.social and Personalis have found that a test to detect circulating tumour DNA can help predict the outcome of lung cancer treatments 🧪
First authors: James Black, Gabor Bartha
Senior author: @charlesswanton.bsky.social
www.crick.ac.uk/news-and-rep...

Predicting lung cancer outcomes with tumour DNA in the blood Scientists from the Francis Crick Institute, UCL, UCLH and Personalis have found that a test to detect circulating tumour DNA can predict lung cancer outcome in a Cancer Research UK-funded study.

Scientists led by James Black, Gabor Bartha and @charlesswanton.bsky.social from 🇬🇧 @crick.ac.uk, 🇬🇧 @ucl.ac.uk, 🇬🇧 @uclh.bsky.social and 🇬🇧 Personalis have tested a method which detects circulating tumour DNA (ctDNA), to predict the risk of #lungcancer relapse before surgery.

Good to be involved in the @cancerresearchuk.org #ClinicalReseachers meeting at @rcn.org.uk Cavendish Sq.

Great opportunity to meet other #ClinicianScientists, network & discuss high quality science.

@thineskrishna.bsky.social @charlesswanton.bsky.social
@clareturnbull.bsky.social

Thrilled our review was selected as a #science #highlight in this #Cell timeline of the last decade 🧪

"Embracing #cancer complexity: Hallmarks of systemic disease"

Swanton et al, 2024

www.sciencedirect.com/science/arti...

@charlesswanton.bsky.social
@cancerresearchuk.org
@cp-cell.bsky.social