Novel reporters for inclusion damage revealed instability of CpoS-deficient inclusions. Top left: Schematic showing the principle of detecting inclusion damage using the split-GFP approach. Right: Fluorescence microscopic detection of inclusion damage during infection with CTL2-cpoS::cat. HeLa cells were transfected with a plasmid driving GFP1–10 expression, infected with the indicated strains (5 IFU/cell), and then fixed, stained (DNA (Hoechst) staining), and imaged at 26 hpi (scale = 20 µm). Bottom left: FIB-SEM analysis validating inclusion damage at the ultrastructural level. GFP1–10-expressing HeLa cells were infected with the indicated strain and fixed at 24 hpi. A cell containing green-fluorescent bacteria was identified by fluorescence microscopy and subjected to FIB-SEM analysis (scale = 1 µm, green arrows highlight bacteria in the host cell cytosol).
Intracellular pathogens like #Chlamydia can hide from host defenses in a #vacuole. This study shows that CpoS maintains the stability of Chlamydia’s parasitophorous vacuole; early vacuole destabilization clears infection, suggesting a potential therapeutic target @plosbiology.org 🧪 plos.io/3Ur0YqJ
13.08.2025 07:46 — 👍 14 🔁 4 💬 1 📌 0
Ran my first 10k in beautiful Heidelberg 🙂↔️
And got to see some babies on the way!
25.06.2025 05:23 — 👍 6 🔁 0 💬 0 📌 0
Just a few minutes for this really great conference to start! Amazing talks, superb program and beautiful city
Happy as always to represent @plosbiology.org at #EESMicrobiology
Feel free to approach and have a chat!
24.06.2025 11:46 — 👍 16 🔁 2 💬 0 📌 0
📅 I am organizing a session on #ERC funding opportunities at the EMBO | EMBL Symposium-Infection: pathogens, hosts, and microbiomes. 26-28 May 2025. If you are around, feel free to stop by. @erc.europa.eu @embl.org
29.04.2025 15:24 — 👍 4 🔁 1 💬 0 📌 0
Excited to join next week to this @embl.org symposium #EESInfection!
The program looks great and I am happy to say that @plosbiology.org will be giving 2 poster prizes!
As always, reach out if you are going to be there too!
23.05.2025 19:03 — 👍 4 🔁 1 💬 1 📌 1
Great talk from @audeber.bsky.social about defense system diversity.
And then also from @pdeweirdt.bsky.social from the lab of one of our Editorial Board Members Michael Laub.
So much to still discover!
08.04.2025 13:22 — 👍 2 🔁 0 💬 0 📌 0
So excited to participate on this @embo.org workshop representing @plosbiology.org! There'll be amazing talks & posters! Feel free to come to me! I'm always happy to chat ;)
I'll also take the opportunity for a site visit @institutpasteur.bsky.social Mon & Fri, so reach-out if you are there!
06.04.2025 06:36 — 👍 5 🔁 2 💬 0 📌 0
Happening TODAY! It is not too late to register for the #FEMSMicrobiolEcol Webinar.
This session will not only push the boundaries of ecological understanding but also underscore the critical role of microbes in addressing environmental challenges.🌍
buff.ly/3X6aCR9
27.03.2025 08:00 — 👍 5 🔁 3 💬 0 📌 0
Reviewer fatigue is there. Check out this editorial :)
If you have ideas that you think we should consider feel free to comment. I am already aware that a solution may be to pay reviewers, it will be interesting to see the outcome from CoB, and how affordable that is (specially for non-profits)
27.03.2025 07:59 — 👍 8 🔁 1 💬 0 📌 0
Zoom Scheduler
Zoom external booking management
What is up Bluesky!
I'm an Associate Editor working at #PLOSBiology with everything related with #Microbiology and #Immunology
Looking forward to all #science posts!
Also, if you wanna book a meet-the-editor zoom meeting with me and talk about your work, just click scheduler.zoom.us/melissa-vazq...!
24.03.2025 18:35 — 👍 54 🔁 10 💬 1 📌 1
Three AI-powered steps to faster, smarter peer review
Tired of spending countless hours on peer reviews? An AI-assisted workflow could help.
Let's talk about this Nature piece in more detail.
I've rarely read something so anti-scientific anywhere short of the National Review.
www.nature.com/articles/d41...
06.03.2025 05:34 — 👍 1640 🔁 692 💬 62 📌 142
Super fun to be part of this. Thank you @sparrerlab.bsky.social for inviting me to talk a bit about AI in scientific publishing!
03.03.2025 17:41 — 👍 2 🔁 0 💬 0 📌 0
Really happy to attend the "Molecular Determinants of Zoonotic Virus Infections and Beyond" meeting in Freiburg representing @plosbiology.org
I will also have a meet the editor session this Friday, so come over!
As always, feel free to reach out in person, by e-mail or dm
26.02.2025 17:23 — 👍 10 🔁 1 💬 0 📌 0
In this uncertain and weird times, I am so happy and proud to be part of @plos.org and @plosbiology.org.
"PLOS will not compromise on issues of scientific rigor & editorial integrity... we seek diversity because more expert voices make for better science"
21.02.2025 17:36 — 👍 6 🔁 1 💬 0 📌 0
Important then, and even more important now...
Also, I have to say that I am quite proud of this team, PLOS and the values we support
19.02.2025 17:01 — 👍 13 🔁 3 💬 0 📌 0
biology is so beautiful!
08.02.2025 13:39 — 👍 1 🔁 0 💬 0 📌 0
Top: Immunofluorescence assay of cKD-TgHCF101 treated for 7 days in the presence of ATc, cyst wall is labeled with DBL, parasites are outlined with anti-IMC3 antibody and DNA is stained with DAPI. Bottom: Schematic representation of the putative organization of the CIA pathway in T. gondii. This scheme places TgHCF101 as an Fe-S transfer protein from the CTC to client protein ABCE1. Plant nomenclature was used for the purpose of the figure, but names for human homologs are mentioned between brackets when appropriate.
Iron-sulfur proteins require specialized assembly pathways. @s-besteiro.bsky.social &co show that the plastid-derived protein HCF101 functions in the cytosolic Fe-S assembly pathway in #Toxoplasma and is crucial for #parasite viability 🧪 @plosbiology.org plos.io/3EFKKoQ
07.02.2025 18:19 — 👍 19 🔁 5 💬 0 📌 0
quite a nice study from the @maierlab.bsky.social
03.02.2025 10:55 — 👍 3 🔁 2 💬 0 📌 0
In a see of horrible, and sometimes disheartening news, here is a picture of my ninja cat enjoying the sun
28.01.2025 10:40 — 👍 3 🔁 0 💬 0 📌 0
a hot pink flip phone with a DNA strand on the screen next to courier font text that says "Text a teacher: You can get matched with a scientist for a virtual Q&A in your classroom for free with skype a scientist"
500 classrooms have signed up for Skype a Scientist 2025!
@skypeascientist.bsky.social matches scientists with classrooms, scout troops, libraries, & other groups for Q&A sessions. It's FREE!
We have an advertising budget of $0. So tell an educator in your life that we exist
SkypeAScientist.com
23.01.2025 22:58 — 👍 332 🔁 155 💬 15 📌 6
🥳🥳
16.01.2025 12:02 — 👍 1 🔁 0 💬 0 📌 0
If you're just getting back on Bluesky, welcome to 2025! Here's a 🧵 on the editors' highlights of the stuff that we published in @plosbiology.org last year, compiled in this v nice editorial by @droutledge.bsky.social ...
03.01.2025 13:28 — 👍 16 🔁 4 💬 1 📌 0
This has also been my first year as editor and being part of this amazing team was one of the best things in 2024.
I would like to thank the whole team and the Academic Editors for their help and patience, the authors for their trust, and the reviewers for their hard work.
Happy holidays everyone!
22.12.2024 20:03 — 👍 8 🔁 0 💬 0 📌 0
Left: Causal network analysis leveraging annotated interactions (transcription factor-target, kinase-substrate, phosphatase-substrate) as a framework to evaluate protein expression changes (late exhaustion versus resting) to predict key nodes. Right: A pruned version of a large subnetwork with p300 (black outline) as the main hub.
Repeated antigen exposure drives T-cell exhaustion, impairing immune function. Study identifies HAT p300 as a driver of CD4+ #Tcell exhaustion, implicating novel surface receptors & transcriptional regulators, and a metabolic shift to dysfunctional fatty acid oxidation 🧪 #PLOSBiology plos.io/4glg2iO
18.12.2024 17:25 — 👍 19 🔁 6 💬 2 📌 0
It is happening! Make sure to follow @plosbiology.org and all other @plos.org journals to keep on track with great science!
17.12.2024 08:14 — 👍 16 🔁 4 💬 0 📌 0
Open call for new research groups @pasteur.fr in Paris lots of immunology themes welcome #immunosky #IDsky #Scisky 🧪🥼🔬 get in touch if you have questions
14.12.2024 14:41 — 👍 46 🔁 40 💬 3 📌 1
Happy to say I will be attending and representing @plosbiology.org
I will post again closer to the dates but I am sure it will be a great conference!
12.12.2024 12:03 — 👍 0 🔁 0 💬 0 📌 0
Hi! @plosbiology.org has a bit of neuroscience in there! We actually just published a collection related to it!
12.12.2024 11:57 — 👍 0 🔁 0 💬 0 📌 0
Professor of Theoretical Biology at the University of Würzburg
Senior Editor at Nature Microbiology 💻📄 | handling mycology, parasitology, AMR and phage therapy | https://www.nature.com/nmicrobiol/
MD, PhD. Postdoc in Slack and Sunagawa labs, ETH Institute of Microbiology. Typas lab alumna.
Bacteria as friends and foes.
PhD. 🏳️🌈
Immunology, aging and bioinformatics enthusiast. @MSCActions postdoc at @i2sysbio.bsky.social @csic.es
PI @ #tomsbiolab, Chair of #Grapedia COST, RyC researcher
@i2sysbio, #phytopharmaceuticals #functionalfoods #systemsbiology #LGBTSTEM 🏳️🌈🇨🇱🇪🇸
tomsbiolab.com
Computer scientist at I2SysBio-CSIC. Transcriptomics, long-reads, multiomics, tool developer. Promoter of Green Science. Finally happy!
News from the Genomics of Gene Expression Lab at
@i2sysbio.bsky.social @elcsic.bsky.social. Led by @anaconesa.bsky.social
PathoGenOmics research group at I2SysBio. Having fun learning how pathogens evolve.
ℙ𝕙𝕪𝕤𝕚𝕔𝕚𝕤𝕥, ℝ𝕖𝕤𝕖𝕒𝕣𝕔𝕙 𝔾𝕣𝕠𝕦𝕡 𝕃𝕖𝕒𝕕𝕖𝕣 @ 𝕀𝟚𝕊𝕪𝕤𝔹𝕚𝕠 (ℂ𝕊𝕀ℂ-𝕌𝕍) 🤓, 𝕀ℙ𝔸/𝔽𝕠𝕠𝕕 𝕃𝕠𝕧𝕖𝕣 😍, 𝕒𝕟𝕕 ℙ𝕒𝕤𝕥𝕒𝕗𝕒𝕣𝕚𝕒𝕟!
#BDS
http://www.thesimbiosys.com
@csic.es Tenured Scientist at @i2sysbio.es. Comparative omics, bioinformatics and experimental evolution.
Tenured Researcher on Computational Systems Biology
Institute for Integrative Systems Biology (@i2sysbio.bsky.social), @csic.es
visitor at @bsc-cns.bsky.social, @alfonsovalencia.bsky.social team
also at @arnaumontagud@fediscience.org
Synthetic biology designer
Evolutionary biochemist at I2SysBio, University of València and CSIC.
Aprenent de gastronomia científica en Benimaclet.
Plant-pathogen interaction, RNA silencing, epigenetics and general science. Group leader at http://i2sysbio.uv.es Enjoy the silence!
Group Leader of the Viral Biology group at I2SysBio. RNA viruses, experimental evolution, amateur farming, and rock climbing. Opinions are mine, not those of the lab. 🇮🇱🇺🇸🇪🇸
Evolutionary biology, genomic epidemiology, pathogens, phylogenies, phylogenomics, bioinformatics, population genetics and genomics, forensics, and anything to which evolutionary analyses of genes and genomes can be applied to. Squash player (still).
Decoding #TB 🦠 mysteries at @pathogenomics.bsky.social | Bioinformagician wielding data to unlock genetic secrets 🧬💻 | Check out my code on GitHub https://github.com/paururo
Researcher at https://www.crm.cat/ + CSIC Associated Unit I2SysBio/CRM https://www.i2sysbio.es/associated-units/ • Dynamical Systems • Nonlinearity • Biology
Virus evolution, virus ecology and epidemiology, host-virus interactions, systems biology, mathematical modeling, complex systems.
Arabidposis thaliana/potyvirus and Caenorhabditis elegans/Orsay virus
Our mission is to address climate change, advance sustainable agriculture, and conserve biodiversity through innovative plant research. Our goal is to help create a sustainable future where ecological equilibrium is maintained.
