Vishal Mohanakrishnan

❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!

www.nature.com/natcardiovas...

I am honoured to be elected as a Member of EMBO and look forward to contributing to its mission and community!

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations Nature Cardiovascular Research - Kraft et al. identify TIE2 activation as a key driver of PIK3CA-related venous malformations and demonstrate that inhibiting TIE2 signaling can suppress the growth...

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Read our work in ‪@natcardiovascres.nature.com by Marle Kraft et al.

rdcu.be/enhST

📢 #GRC_Angiogenesis program is up! We have an amazing lineup of speakers ready to dive into the "social life" of vessels! How they engage with their neighbors, how they connect, and why they break up! Plus we have ~15 slots available for short talks! Apply (link 👇) and see you in Newport in July!

Not every organ ages the same🤠

With Age, Skull bone marrow Vasculature+HSPC Expand & ⏫ contribution to peripheral leukocyte

Skull BM expands with Pregnancy CML PTH Stroke

@bikohcello.bsky.social
@vishalmkrishnan.bsky.social
@ralfhadams.bsky.social
@nature.com 2024
www.nature.com/articles/s41...

I am a bit biased, but check out the beautiful work and thread by @hansschoofs.bsky.social @taijamakinenlab.bsky.social on why lymphatic endothelial cells have their jigsaw puzzle-like shape 😍😍😍

Cell and Tissue Dynamics (Wickström)

My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email

#EVBOSummerSchool 2025: Please help spread the news!
10-11 June 2025 | Biomedicum Helsinki, Finland
Registration will open soon. Stay tuned!
The summer school will be preceded by the excellent and free-of-charge Wihuri Research Symposium on Cardiovascular Biology!

More info buff.ly/42I9fvY

Type R capillary #EndothelialCell in Bone
Cav1+ Efnb2+Flt4-Emcn+
B/w Sinusoid EC & Artery
👉Close to trabecular🦴 osteoprogenitor osteoclast
👉Angiocrine SEMA7A+

⏫by #Aging anti-osteoporosis therapy

@vishalmkrishnan.bsky.social l @ralfhadams.bsky.social #NatCellBio 2024
www.nature.com/articles/s41...

Thank you very much @haoyin.bsky.social ! Beautiful summary! 😊🙏

How the brain cleans itself during deep sleep Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ.

Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ

https://go.nature.com/3PwtwN2

The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes Nature Metabolism - Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.

Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)

Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...

Aaaaand finally:
#NCB2024
In November, @ralfhadams.bsky.social & co identified a distinct subset of post-arterial #capillaries, termed type R, which contribute to trabecular #bone formation in the diaphysis and respond to anti-#osteoporosis treatments.
www.nature.com/articles/s41...

Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stress Blood vessels in mammalian embryos develop from initial aggregates of endothelial cell (EC) progenitors, which coordinate the opening and stabilization of central vascular lumens, all while under prog...

Pleased to share the work of Mitzy Cowdin and others in our lab showing the requirement for the Hippo pathway kinases Lats1 and 2 for endothelial sensing of hemodynamic flow and for vascular remodeling during embryogenesis 🎉🧪

www.biorxiv.org/content/10.1...

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/

Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...

🥂Congratulations to @ralfhadams.bsky.social @vishalmkrishnan.bsky.social & co for their new Open Access study in our journal (@naturecellbiology.bsky.social) identifying type R #capillaries and showing their role in trabecular #bone formation in the diaphysis.
www.nature.com/articles/s41...

Many thanks for your kind words and support for our work! 😊🙏

Happy #FluorescenceFriday

Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...

💫NEW: @ralfhadams.bsky.social & co identify a distinct subset of post-arterial #capillaries, termed type R. They show that type R capillaries contribute to trabecular #bone formation in the diaphysis and respond to anti- #osteoporosis treatments.
www.nature.com/articles/s41...

Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries". 🦴🔬😍

Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology.

www.nature.com/articles/s41...

Here's a starter pack focusing on cardiovascular research.
I'm sure the pack is incomplete. If you'd like to be added to the list, please let me know!

go.bsky.app/SgaGkv5