Yasuhiro Kadota

Pomelo on tatami as the cover of RIKEN Research www.riken.jp/medialibrary...

Discovery and engineering of synthetic RLKs | Plantae Receptor-like kinases (RLKs) are abundant genes that have diversified and expanded throughout plant evolution, with most plants having hundreds or more RLKs. In this exciting new paper, Ngou et al.

Plant Science Research Weekly -- Discovery and engineering of synthetic RLKs (Science) @shirasulab.bsky.social @brunongou.bsky.social @yasukadota.bsky.social @BrunoNgou (Summary by Mary Williams @PlantTeaching.bsky.social) buff.ly/JlJKjJE

#PlantaePSRW

Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants Plant peptide hormones regulate and induce the parasitic plant specialized organ for connecting to and feeding from the host.

Well done, Max! Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants | Science Advances www.science.org/doi/10.1126/...

this research is potentially also interesting to botanical industries (herbalist, food, cosmetics, cannabis, etc.) and maybe even to pharma, because a lot of the botanically derived extracts those industries use come from plant immune systems and their structure and function against pathogens.

Discovery and engineering of synthetic RLKs | Plantae Receptor-like kinases (RLKs) are abundant genes that have diversified and expanded throughout plant evolution, with most plants having hundreds or more RLKs. In this exciting new paper, Ngou et al.

Discovery and engineering of synthetic RLKs

plantae.org/discovery-an...

BIK1-RIN4 complex links plant immunity and pathogen virulence Plants deploy receptor-like cytoplasmic kinases (RLCKs) and the immune hub protein RIN4 to coordinate PAMPs-triggered immunity (PTI). Here, we show that BIK1, but not its close homolog PBL1, dynamical...

BIK1-RIN4 complex links plant immunity and pathogen virulence

www.biorxiv.org/content/10.1...

理研、植物が病原体からの「危険サイン」を検知するセンサーの役割を持つ免疫受容体をさまざまな種から探索する方法を開発 - 日本経済新聞 【プレスリリース】発表日:2025年09月05日病原体を見分ける植物のセンサーをデザイン―免疫受容体を人工設計し新たな病原体の認識を可能に―【概要】理化学研究所（理研）環境資源科学研究センター植物免疫研究グループの白須賢グループディレクター（環境資源科学研究センター副センター長）、ブルーノ・ポクマン・ゴウ基礎科学特別研究員、門田康弘専任研究員らの国際共同研究グループは、植物が病原体から

理研、植物が病原体からの「危険サイン」を検知するセンサーの役割を持つ免疫受容体をさまざまな種から探索する方法を開発 - 日本経済新聞 www.nikkei.com/article/DGXZ...

Thanks!

Game-changing biotech for engineering pathogen-resistant crops Researchers at the RIKEN Center for Sustainable Resource Science (CSRS) in Japan have identified an ancient protein, which they have named SCORE, that has the potential to help defend plants against t...

Game-changing biotech for engineering pathogen-resistant crops | EurekAlert! www.eurekalert.org/news-release...

病原体を見分ける植物のセンサーをデザイン | 理化学研究所
www.riken.jp/press/2025/2...

Excited to announce that our latest paper has just been published in Science!

ttps://www.science.org/doi/10.1126/science.adx2508

Systematic discovery and engineering of synthetic immune receptors in plants Plants deploy a diverse array of pattern recognition receptors (PRRs), which perceive microbe-associated molecular patterns to activate immune responses. Leucine-rich repeat receptor-like kinase subgr...

Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org !

www.science.org/doi/10.1126/...

With this approach, we aim to characterize more PRRs against different pathogens & pests in the future.

I am very grateful to Michele & Marc, Takehiro & Dohmae-san, Markus, @yasukadota.bsky.social & @shirasulab.bsky.social for their support. Also big thanks to the reviewers and editors for improving our manuscript!

Registrations are rolling in for the 2025 Stromlo Plant Pathology meeting in Canberra (Nov 27–28)! Secure your spot! Speakers: @yasukadota.bsky.social, Cecille Segonzac, @thamlab.bsky.social, @yichangsung.bsky.social, Tek Tay & @danielsyu.bsky.social. Register at tinyurl.com/3e3tx9j2
#strompath25

A cell wall-associated kinase phosphorylates NLR immune receptor to negatively regulate resistosome formation - Nature Plants The discovery of the resistosome was a milestone in plant immunity. Here, Zhong et al. identify a kinase that phosphorylates the NLR, and reveal how this kinase regulates resistosome assembly to fine-...

🌱 From Nature Plants: Phosphorylation of NLR immune receptors by a cell wall–associated kinase limits resistosome assembly, fine-tuning plant immune responses. (Savithramma P. Dinesh-Kumar)

▶️ www.nature.com/articles/s41...
#PlantBiology #PlantScience

Our new work uncovering how WIND1 promotes somatic embryogenesis as a bifunctional chromatic regulator!!!!

We knew WIND1 promotes new fate acquisition and now we show WIND1 also helps repressing existing identity!

WIND1 controls cell fate transition through histone acetylation and deacetylation during somatic embryogenesis https://www.biorxiv.org/content/10.1101/2025.08.07.669221v1

A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale.

Single-gene-per-cell delivery coupled to an effective transcriptional selection system

www.biorxiv.org/content/10.1...

植物は「危険サイン」で寄生線虫を察知　糸状菌や昆虫も同じ仕組みで認識か　理研×農研機構×JST 理化学研究所（理研）環境資源科学研究センター植物免疫研究グループの白須賢グループディレクター（環境資源科学研究センター副センター長）、門田康弘専任研究員、飯野絵里香研修生（研究当時）、農研機構植物防疫研究部門基盤防除技術研究領域の植原健人研究領域長らの国際共同研究グループは、植物が植物寄生線虫のような動物型の病原体を分子レベルで認識する仕組みを初めて明らかにした。

www.jacom.or.jp/saibai/news/...

Congratulations on your paper! I’m sure you remember—bring a bottle of champagne worth the impact factor × 1,000 yen to celebrate your paper and the lab’s 20th anniversary ♥
A cherished rule of the Shirasu Lab.

Big congratulations🎉🎉🎉

Chitin Soil Amendment Triggers Systemic Plant Disease Resistance Through Enhanced Pattern‐Triggered Immunity Chitin triggers localised and systemic plant immune responses, making it a promising treatment for sustainable disease resistance. However, the precise molecular mechanisms underlying chitin-induced ...

Chitin Soil Amendment Triggers Systemic Plant Disease Resistance Through Enhanced Pattern‐Triggered Immunity - Makechemu - Plant Biotechnology Journal - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Thanks! This was the hardest project I've ever done.

A trehalase-derived MAMP triggers LecRK-V–mediated immune responses in Arabidopsis Trehalase-derived peptides trigger LecRK-V-mediated plant immunity, potentially enabling broad detection of pathogenic organisms.

原文はこちら
www.science.org/doi/10.1126/...

A copper-dependent, redox-based hydrogen peroxide perception in plants Redox-related molecules, such as quinones and reactive oxygen species (ROS), are important signaling molecules for all living organisms. A plant-specific leucine rich-repeat receptor-like kinase (LRR-...

Exciting preprint! CryoEM structure of plant ROS & quinone receptor CARD1 (also known as HPCA1) reveals it is a copper dependent redox sensor (and cys residues not essential). CARD1 is a member of LRR-RLK clade VIII-1. www.biorxiv.org/content/10.1...

植物は“危険サイン”により寄生線虫を察知する 理研らの国際共同研究グループは、植物が植物寄生線虫のような動物型の病原体を分子レベルで認識する仕組みを初めて明らかにしました。

植物が寄生線虫や昆虫を認識するメカニズムを解明しました！

植物は“危険サイン”により寄生線虫を察知する
www.riken.jp/press/2025/2...

🎉 Our new paper is out in Science Advances!
Plants can detect parasitic nematodes.

www.science.org/doi/full/10....

Here comes the final version.
Congratulations Erika, Yasu, Ken, and all others involved!
@yasukadota.bsky.social @shirasulab.bsky.social

www.science.org/doi/10.1126/...

Unlocking expanded flagellin perception through rational receptor engineering - Nature Plants Receptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of flg22 variants, allowing the ...

Excited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by @jerrytli.bsky.social www.nature.com/articles/s41...