We are all mosaics: vast genetic diversity found between cells in a single person Nature - Technical advances allow researchers to trace the genetic changes that occur over time.

“There were some cells in there that were very messed up”

In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/4rvXH8Y

CRISPR vs. cholesterol: can gene editing prevent heart disease? Promising results from a small clinical trial highlight a growing interest in designing gene-editing treatments for common illnesses.

Gene editing could one day be harnessed to provide a one-stop treatment for a common cause of heart disease

go.nature.com/4nSyzGc

‼️ Excited to share our new paper out now in @science.org ‼️

We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.

Link: www.science.org/doi/epdf/10....

Thread ⬇️ (1/8)

Cambridge Amgen Scholars Programme 2026 is now open. Great opportunity for undergrad students from UK and Europe to join Cambridge labs.
Happy hear from anyone interested in joining our group at @cambiochem.bsky.social
amgenscholars.bio.cam.ac.uk

Reshaping of a Glycoside Hydrolase Active Site through Expression-Compensated Droplet-Based Microfluidic Screening Provides Useful Tools for Glycomics The glycosylation of proteins endows them with distinct biophysical properties and allows them to play fundamental roles in cellular communication. Much of our understanding of glycoproteins has deriv...

Beautiful enzyme evolution work by Steve Withers and coworkers 👏

pubs.acs.org/doi/10.1021/...

If this gene therapy approach is as good as it looks, this is amazing.

PDB101: Learn: Flyers, Posters, & Calendars: Posters: Folding of Protein Domains This poster highlights common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme.

Download this PDB-101 poster highlighting common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme

This is a cool approach!

Global effort to sequence all life on Earth ramps up The Earth BioGenome Project is accelerating its efforts tenfold to sequence all life on Earth by 2035.

In the face of climate change, the race to understand life on Earth is on.

@ebpgenome.bsky.social is scaling up tenfold to sequence all known species by 2035.

At EMBL-EBI, we annotate these genomes, making them openly available for the global research community.

www.ebi.ac.uk/about/news/a...

This ‘landmark’ study describes the structural mechanism of strand exchange by the RAD51 filament using cryogenic structural, biochemical, and single-molecule analyses.
buff.ly/Ieh84gj

Aggresomes protect mRNA under stress in Escherichia coli - Nature Microbiology Ribonucleoprotein aggresomes exclude ribonucleases and protect mRNA to promote rapid translation reactivation and cellular recovery after stress alleviation in Escherichia coli.

Aggresomes protect mRNA under stress in Escherichia coli
www.nature.com/articles/s41... "prolonged stress leading to ATP depletion in Escherichia coli results in increased aggresome formation, compaction and selective mRNA enrichment within these aggresomes" 🦠 #microsky #rnasky

Accelerating Biomolecular Modeling with AtomWorks and RF3 Deep learning methods trained on protein structure databases have revolutionized biomolecular structure prediction, but developing and training new models remains a considerable challenge. To facilita...

(1/7)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)

[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)

Undruggable No More: AI Hits Disordered Proteins, Unlocks Therapy Targets David Baker’s lab has successfully designed binders to disordered proteins, expanding therapeutic access to over 50% of the human proteome.

Undruggable No More: AI Hits Disordered Proteins, Unlocks Therapy Targets
David Baker’s Nobel Prize-winning lab has successfully designed high affinity binders to disordered proteins, expanding therapeutic access to over 50% of the human proteome
www.genengnews.com/t...

Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...

Seven Physics students stand behind a LEGO model of the Lovell Telescope smiling

What a way to celebrate Manchester’s cosmic legacy 🤩

Students from our Physics Society have constructed a remarkable 30,500-piece LEGO model of the iconic Lovell Telescope at Jodrell Bank.

@jodrellbank.bsky.social

“If I am elected, I will be an active, inclusive, and engaged Chancellor for a new era.”
A clip from the recent Cambridge Chancellor webinar.
(For more information on the election and to sign up for updates, please visit www.chancellorforanewera.co.uk . Thank you.)
#cambridge #cambridgechancellor

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Marking exams

RAD51 D-loop

🧬 Thrilled to share that our latest work, A landmark study uncovering intricate molecular details of the human DNA repair process.
📰 Press release: elifesciences.org/for-the-pres...
📄 Full article: elifesciences.org/reviewed-pre...

Proud of the team #DNADamage #CryoEM #CambridgeUniversity

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM

“Next week will be quieter“, he mutters to himself for the 792nd week in a row

You want to start tomography? Solve structures inside cells? Reach Nyquist 😳 ? @phaips.vd.st and I have a website for you! tomoguide.github.io
You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomogram averaging, using different software!
Hope it will be useful !

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

Woah- going to try this out!

Vampire caught unawares by sudden British heatwave. 🧛‍♂️🌞

Many thanks to Professor Hannah Fry, Cambridge’s Professor of the Public Understanding of Mathematics and a Fellow of Queens’, for her kind and thoughtful words.

#cambridge #cambridgechancellor @cambridgeup.bsky.social

Along with every geneticist I am a total Mendel groupie and this new figure (www.nature.com/articles/s41...) that shows the chromosome location and underlying basis of his allelic pairs moves me to near-tears. Oh, to fly back in time and show this to him ...

I just wanted to let you know that, having been encouraged by many and received over four times the number of nominations required, I announced today that I am throwing my hat into the ring for the election of the next Chancellor of the University of Cambridge...
1 of 2

Amazing proteins.

New blog post: Making teaching laboratories more inclusive and accessible - how would you spend £1 million? #HigherEducation #Inclusion #STEM