Marianna Parlato

In many #IBD patients, motility disorders persist even during remission. Kurapati et al. show that postinflammatory GI motility dysfunction arises from structural remodeling of the enteric nervous system, driven by a combination of neuronal loss & neurogenesis. rupress.org/jem/article/...

Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications - Nature Reviews Drug Discovery The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway mediates cellular responses to cytokines and growth factors, and its dysregulation plays a role in various disord...

The JAK–STAT pathway is an important target for drugs for inflammatory and autoimmune disorders. This Review discusses recent advances in JAK and STAT inhibitor development and highlights emerging therapeutic indications nature.com/articles/s41... rdcu.be/eXDui

Pathobiont-triggered induction of goblet cell response drives regional susceptibility to Inflammatory Bowel Disease @jci.org @vanderbilt.edu
www.jci.org/articles/vie...

New online! Nutritional maintenance therapy for paediatric patients with Crohn’s disease

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/

www.nature.com/articles/s41...

To strengthen the European research on early life immunology we have started the EFIS study ELINE
Info and seminar announcement 👇🏼
#EFIS#ELINE#immunology

Replacing Microbiota Makes Aging Intestines Young Again @alenghatlab.bsky.social @cincyresearch.bsky.social
www.cell.com/stem-cell-re...

scienceblog.cincinnatichildrens.org/replacing-mi...

Decoding cytokine networks in ulcerative colitis to identify pathogenic mechanisms and therapeutic targets Systems immunology reveals how cytokine-cytokine signaling is dysregulated in an inflammatory bowel disease.

Why do many UC patients struggle despite cutting-edge biologics? We suspected the answer lies not in individual cytokines, but in how they communicate as an interconnected network during disease and treatment. Our new
KorcsmarosLab paper published in Science Signaling
www.science.org/doi/10.1126/...

This is a second of a 2-part episode on allergy. I discuss anaphylaxis at the skin and intestinal barriers with two incredible powerhouses - Steph Eisenbarth and Caroline Sokol.

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes - Nature Genetics Nature Genetics - Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

20 years ago today we first reported the TCF7L2 association with type 2 diabetes @natgenet.nature.com. Much to still figure out for this locus....

www.nature.com/articles/ng1...

Fasting-mimicking diet is superior to a baseline diet for inducing clinical response, clinical remission and biochemical improvement in mild-to-moderate Crohn's disease @naturemedicine.bsky.social
www.nature.com/articles/s41...

🧬 New in @cellpress.bsky.social 🧵
1/ With @casanovalab.bsky.social , we propose a rethinking of monogenic disorders of immunity:
👉 common variants can matter — a lot.

Monogenic disorders of immunity: Common variants are not so rare While monogenic disorders of immunity typically involve rare alleles, some arise from alleles common in specific populations. Examples include IFNAR1/2 null alleles in the Arctic/Pacific and PTCRA hyp...

Perspective @casanovalab.bsky.social @vbeziat.bsky.social
Monogenic disorders of immunity: Common variants are not so rare
www.cell.com/cell-genomic...

In vivo detection of immune responses via cytokine activity labeling @cellcellpress.bsky.social @harvardmed.bsky.social
www.cell.com/cell/fulltex...

Review @natrevdrugdiscov.nature.com
Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications
www.nature.com/articles/s41...

A genome-wide association study identifies a genetic variant that reduces risk of leukemia
@science.org @kharaslab.bsky.social @mskcancercenter.bsky.social @bloodgenes.bsky.social @hhmi-science.bsky.social @bostonchildrens.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Update: 118 manuscripts reviewed in 2025.

Immune Functions of the Esophagus The esophagus has long been regarded as a simple conduit for food transport. A new paradigm now recognizes it as an immune organ actively involved in …

Review @jacionline.bsky.social
Immune Functions of the Esophagus
www.sciencedirect.com/science/arti...

Estrogen tunes a cross-talk between hormone-secreting cells in the mouse gut to regulate visceral pain
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org @hollyingraham.bsky.social

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...

So structural biology is not dead after all 😋 Not a big surprise The title of this article is exactly in line with what I think.
Same applies to LLMs for scientific writing.

Clinical Characteristics, Management, and Hematopoietic Cell Transplantation of Patients with TLR8 Gain-of-Function Key Points. TLR8 GOF is an X-linked dominant disease that should be considered in both male and female patients with cytopenia and immune dysregulation.Pat

Excited to see our update on the clinical disease and treatments for TLR8 GOF (INFLTR8) out now! We now report a total of 10 patients, including a female patient as this is a rare X linked DOMINANT genetic error of immunity - both germline and mosaic

ashpublications.org/bloodadvance...

Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy Infants from a traditional farming community exhibited antibody profiles that were found to be associated with lower incidence of egg allergy.

Infants from a traditional farming community exhibited antibody profiles that were found to be associated with lower incidence of egg allergy
www.science.org/doi/10.1126/... @urmed.bsky.social

In this study, Panda, Colonna et al. @washumedicine.bsky.social highlight a previously unknown role for SLC7A8 in Th2 cells, with potential implications for understanding and treating type 2 immune-related diseases. rupress.org/jem/article/...

#MucosalImmunology #InfectiousDisease #inflammation

Why we have to continue with animal testing for medical research | Letters Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments

We need to apply @nc3rs.bsky.social principles, ensure animal welfare & do the best possible by research animals. But let's not confuse people or ourselves by thinking they're dispensable.

Why we have to continue with animal testing for medical research | Letters www.theguardian.com/science/2025...

Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage controlling type 1 and 2 immune balance @natimmunol.nature.com @champalimaudf.bsky.social @neuroimmune-rok.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Congrats #Felton #Rothenberg @cincyresearch.bsky.social
Epigenetic and transcriptional programming of murine eosinophils in the esophagus
www.nature.com/articles/s41... @natcomms.nature.com

Panda et al. of the Colonna lab identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. rupress.org/jem/article/...

#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies

@natrevimmunol.nature.com Guidelines for T cell nomenclature
www.nature.com/articles/s41...

Ohhhhh mammoth atlases en route. In 5 years when they get some nuclei we may get spatiotemporal mammoth multiomic data revealing conserved and non conserved patterns of differentiation!

Introducing the Dish Soap Protocol: A Unified Approach for Multi‐Modal Intracellular Staining Recent advances in dyes and cytometers have seen an exponential increase in the ability to perform multidimensional flow cytometry. As we increase our capacity to extract information from cells, the ...

@labliston.bsky.social shared a paper they had written using dish soap as a permeabiliser for Flow Cytometry:

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Someone I work with tried it, and it had the additional benefit of reducing Autofluorescence, which will give you better data!