Alexander Hogrebe, PhD

Save the date! 🗓️

The YPIC Annual Proteomics Gathering is returning for the 3rd time and is coming to Madrid in April 2026! 🎉

Seats will be limited to around 100 participants, so stay tuned and be ready to secure your spot! ✨

#APG2026 #YPIC #Proteomics #EuPA

I love the subtlety, at least no room for ambiguous results

🎉 Save the Date: Our 20th Webinar! 🎉
📅 11 December
🕓 4:00 PM (CET)
Outreach is no longer just a “nice addition” in science — it’s becoming essential for grants, visibility, and impact. 🌍✨
🔗 Register here:
us06web.zoom.us/meeting/regi...
Let’s bring science closer to everyone! 💬🔬🌟

Klimapolitik wird oft kritisiert, Populismus zu fördern. Dabei zeigen Forschungen: Populisten nutzen Themen gezielt, um anti-staatliche Botschaften zu verbreiten.

Darüber & viel mehr sprechen Jennifer Morgan & @beyond-ideology.bsky.social in der neuen Folge: l.neudenken-podcast.de/bsky-yt/?fol...

Only way to improve it would be to deliver it with a ukulele

Mapping drug mechanisms with ProteomicsDB: unified omics and cell sensitivity data at scale Abstract. Proteomic and phenotypic cell sensitivity datasets are increasingly important for understanding chemoproteomics and the underlying drug mechanism

Very happy to see that dose-response curves are now super easy to access for everyone in proteomicsDB. Just a few clicks and you can see at which concentrations your favorite drug engages protein target(s), tinkers with signaling pathways, and inhibits cell growth. Read more: doi.org/10.1093/nar/...

In den USA läuft vieles schief, aber es ist unglaublich, wie sich eine gesetzlich verankerte Barrierefreiheit positiv für alle auf den Alltag auswirken kann. Das braucht es nicht um pro Barrierefreiheit zu sein, aber es ein ein gutes Argument gegen "warum sollte mich das kümmern?"

Umbau statt Neubau, das spart erhebliche CO2-Emissionen. Zu diesem Thema gibt es auch eine europäische Petition von @architects4future.bsky.social. Bitte gerne hier unterschreiben: eci.ec.europa.eu/052/public/#...

The deadline is fast approaching!

Write down your ideas and submit an application before the 30th of November. For more information, check out our website: eupa.org/ypic/ypic-st...
🚀

#SPF #YPIC #Funding #ResearchOpportunity #Proteomics

Auch nach 30 Jahren Klimakonferenzen und 10 Jahren Pariser Abkommen schreitet die Klimakrise immer schneller voran. Auf der Konferenz COP30 in Belem muss sich Deutschland klar zum Pariser Abkommen bekennen und eine faire internationale Klimafinanzierung unterstützen. Und wir brauchen endlich einen konsequenten Ausstieg aus Öl, Kohle und Gas! Dafür gehen wir zusammen mit Fridays for Future auf die Straße. 👉 Fr. 14.11.2025, 16:00 Pariser Platz, Berlin

10 Jahre nach dem Pariser Abkommen schreitet die #Klimakrise immer schneller voran. Auf der Konferenz #COP30 in Belem muss sich Deutschland klar zum Pariser Abkommen bekennen und eine internationale Klimafinanzierung unterstützen. Kommt zum #Klimastreik:

👉 14.11.2025, 16:00, Pariser Platz, #Berlin

Post is up! #rstats

rfortherestofus.com/2025/11/quar...

A table showing profit margins of major publishers. A snippet of text related to this table is below. 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year.

A figure detailing the drain on researcher time. 1. The four-fold drain 1.2 Time The number of papers published each year is growing faster than the scientific workforce, with the number of papers per researcher almost doubling between 1996 and 2022 (Figure 1A). This reflects the fact that publishers’ commercial desire to publish (sell) more material has aligned well with the competitive prestige culture in which publications help secure jobs, grants, promotions, and awards. To the extent that this growth is driven by a pressure for profit, rather than scholarly imperatives, it distorts the way researchers spend their time. The publishing system depends on unpaid reviewer labour, estimated to be over 130 million unpaid hours annually in 2020 alone (9). Researchers have complained about the demands of peer-review for decades, but the scale of the problem is now worse, with editors reporting widespread difficulties recruiting reviewers. The growth in publications involves not only the authors’ time, but that of academic editors and reviewers who are dealing with so many review demands. Even more seriously, the imperative to produce ever more articles reshapes the nature of scientific inquiry. Evidence across multiple fields shows that more papers result in ‘ossification’, not new ideas (10). It may seem paradoxical that more papers can slow progress until one considers how it affects researchers’ time. While rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work. The result is a treadmill of constant activity with limited progress whereas core scholarly practices – such as reading, reflecting and engaging with others’ contributions – is de-prioritized. What looks like productivity often masks intellectual exhaustion built on a demoralizing, narrowing scientific vision.

A table of profit margins across industries. The section of text related to this table is below: 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year.

The costs of inaction are plain: wasted public funds, lost researcher time, compromised scientific integrity and eroded public trust. Today, the system rewards commercial publishers first, and science second. Without bold action from the funders we risk continuing to pour resources into a system that prioritizes profit over the advancement of scientific knowledge.

We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing:

a 🧵 1/n

Drain: arxiv.org/abs/2511.04820
Strain: direct.mit.edu/qss/article/...
Oligopoly: direct.mit.edu/qss/article/...

I see @hadley.nz write "I was lucky to have deep conversations about relational database design and Codd’s third normal form much earlier in life than usual" and wonder at what age most people have these conversation. I'm in my fifties and haven't had them yet.
hadley.github.io/25-tidyverse...

Cover: "Klimafaktenpapier. Basisfakten zum Klimawandel, die in der Wissenschaft unumstritten sind. November 2025"

Seit fünf Jahren veröffentlicht @klimafakten.bsky.social gemeinsam mit anderen Institutionen eine regelmäßig aktualisierte Zusammenfassung zum Stand der #Klimaforschung. Eine neue Ausgabe ist jetzt erschienen unter: www.klimafakten.de/kommunikatio...

Standing in front of my poster "MSAID platform: a scalable, cloud-based proteomics platform for the masses" at HUPO 2025 conference in Toronto Canada

I always love the in-depth conference poster discussions, and today was no difference. #HUPO2025 is off to a great start so far

Are you at #HUPO2025? Come say hi at my poster 073 this afternoon, where I present recent developments on our CHIMERYS Platform #proteomics

R/Bioconductor for Mass Spectrometry and Proteomics Dates 17-19 November 2025 To foster international participation, this course will be held online

🎓 Upcoming Online Course: R/Bioconductor for Mass Spectrometry & Proteomics

📅 November 17–19, 2025

Join Dr Laurent Gatto for a hands-on course on mass spectrometry–based proteomics analysis using R and Bioconductor.

👉 Register & learn more: www.physalia-courses.org/courses-work...

The A Bit Fruity podcast had a pretty good episode on her recently, it's wild

It's probably good to never fully trust, while also developing a good sense on which source to trust in which context. Having lived and consumed news in multiple countries, German public broadcasting is really solid (even for queer topics)

Congratulations 🥳

Why fundamental research is fundamental to progress, seeding major breakthroughs
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...

Longtime Joplin user here, it's a great replacement for OneNote. I'm using it on Windows and Android seamlessly, with encrypted cloud storage and possibility to migrate anytime with markdown files

@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"

Proud to be one of the supporting scientists calling the #EU and heads of state to commit to their stated goals of #climate action - to boost our economies, secure our independence and protect lives

A great easy on the differences of LIES, BULLSHIT and WANK (= making strong claims that may not be challenged for ensuring personal moral superiority or fighting fear)

Happy Amazon Prime Day! Amazon collects mountains of data about how you use the service, but there is a setting you can change to make it harder for the company to use that data to sell you more things. #OptOutOctober www.eff.org/deeplinks/2...

Carbon credits are failing to help with climate change — here’s why The idea that emissions can be offset through projects that claim to avoid releases or to remove carbon dioxide from the atmosphere is fatally flawed.

Carbon offsets, though widely used, often fail to deliver real emission cuts. They undermine global climate goals by enabling polluters to avoid reducing fossil-fuel use.

Super spannende erste Folge - ich freue mich auf das, was da noch kommt

Register now! Five days of keynotes, workshops, flash talks, posters, and more on computational mass spectrometry Confirmed keynote speakers Armin Soleymaniniya · Arthur Declercq · Claire Koenig · Hannah Boekweg · Jonas Scheid · Karel Berka · Matthias Anagho-Mattanovich · Roman Bushuiev · Valdemaras Petrosius 📆 19-23 January 2026 📍 Harrachov, Czechia

Registration is now open for the EuBIC-MS Winter School 2026!

Join us in Harrachov, Czechia for a week of keynotes, workshops, and networking on computational MS.

Info and registration: eubic-ms.org/events/2026-...

#EuBIC2026 #MassSpectrometry #MassSpec #Bioinformatics #Proteomics #Metabolomics