Have you heard of E1K?
This month in #OAC learn about E1K, a candidate as a disease modifying #OA drug that alleviates pain and regenerates cartilage simultaneously!
Read more from this work by Moon et al.
www.oarsijournal.com/article/S106...
Have you heard of E1K?
This month in #OAC learn about E1K, a candidate as a disease modifying #OA drug that alleviates pain and regenerates cartilage simultaneously!
Read more from this work by Moon et al.
www.oarsijournal.com/article/S106...
How does MRI T2 mapping of articular cartilage in the knee serve as a biomarker for #OA?🧐
Harlianto et al. found in a population based cohort that T2 values were associated with BMI.
Read more: www.oarsijournal.com/article/S106...
OARSI is excited to announce that NOMINATIONS are open for Publication of the Year! 🤩
Research published in OAC and OAC Open since April 2025 are eligible for nomination!!!
Due March 6th!
Nominate here 🔗: form.jotform.com/223553406964157
🤔 Is there a relationship between osteoarthritis (OA)-induced neuroinflammation and neurodegenerative disorders?
👀 Read all about this interesting topic in this review by Prasoon et al - oarsijournal.com/article/S1063-…
Does #unicompartmental or #bicompartmental joint space width measures reflect whole joint structural damage better?
www.oarsijournal.com/article/S106...
The basic science #EditorsChoice for #Feb is this work by de Roy et al. Learn about the tribological impact of synovial fluid (SF) viscosity and composition during the different stages of #OA!
Read more📚: www.oarsijournal.com/article/S106...
🏳️🌈 Sexual orientation and #OA
⏰ Feb's Editor's Choice by Sha et al. investigated the relationship between #sexualorientation and OA risk in LGBTQIA2S+ population
✅ They found a higher risk of OA in bisexual & lesbian women but a lower risk in gay men
oarsijournal.com/article/S106...
This month in #OAC Hyodo et al. assessed the effects of imeglimin, a novel anti-diabetic agent related to metformin, on the development and progression of knee #OA.
Read more 📚: sciencedirect.com/science/arti...
More #Basic #Science in #OAC this work by Simoes et al. develops a #translational strategy inhibiting aggrecanase activity in #OA using TIMP-3.
Learn more 🔗
sciencedirect.com/science/arti...
New in #OAC, Xu et al. investigates parathyroid hormone-related peptide nuclear localization segment (PTHrP-NLS) and parathyroid hormone 1 receptor (PTH1R) signal-dependent rehabilitative effects of CD90+ chondrocytes on degenerative TMJ cartilage.
oarsijournal.com/article/S106...
How do sex differences in the brainstem alter experimental #osteoarthritis ?🧐
Check out this work by Rodrigues et al.
www.sciencedirect.com/science/arti...
Ziemian et al. demonstrates repetitive loading induced protective effects in the joint & attenuated OA progression over time relative to a single bout of loading even when applied at hyperphysiological load magnitudes known to initiate cartilage damage.
Read more🔗
pubmed.ncbi.nlm.nih.gov/40020990/
The January #EditorsChoice #Basic #Science in #OAC is this review by Wallace et al. Learn about the decreased risk of OA in non-industrialized societies.
Read more: www.sciencedirect.com/science/arti...
As we usher in the new year, we also wanted to celebrate the achievements of a giant in the hashtag#osteoarthritis community.
Read more about Frank's legacy and the Frank Beier Graduate Opportunity Scholarship in this month's issue here: www.oarsijournal.com/article/S106...
🔥 New year new issue!
2026's first editors choice is this large (n>500,000) cohort study on the effects of air pollution on osteoarthritis risk
Read more from Chen et al here: oarsijournal.com/article/S106...
#carbonmonoxide #nitrogendioxide #pm10
#New in #OAC Work from Chen et al. found that treadmill #exercise offers protective effects when initiated early after OA onset but may worsen outcomes if delayed.🏃🏃♂️🏃♀️
🔗
oarsijournal.com/article/S106...
How does Estrogen receptor-α loss accelerate cartilage degradation? 🧐
#New in #OAC this month!
Read more:
www.oarsijournal.com/article/S106...
#OAC #Dec TMJ condylar cartilage exhibits a distinct hyaline microstructure compared to knee cartilage, characterized by higher cell density, smaller cells, and enlarged cell lacunae filled with GAGs, contributing to a load-responsive mechanical behavior.
🔗 www.sciencedirect.com/science/arti...
Where does OA pain really come from? 🤔
December's Editor's Choice (Clinical) suggests it's NOT just the cartilage
Targeting entheses might be next frontier for symptom relief
Read more from Ziegeler et al: www.oarsijournal.com/article/S106...
#New in #OAC Xiao et al. investigates the role of CX3CR1⁺ macrophages and microglia in local inflammation and pain using transgenic mouse models and surgically induced disc herniation model.
🔗
sciencedirect.com/science/arti...
New in #OAC Alimy et al. identified subchondral bone endotypes with distinct clinical and cellular characteristics as a basis for developing novel OA therapies.
🔗
www.oarsijournal.com/article/S106...
This collaborative work from Farhat et al. seeks to learn about the brain-joint connection and reveals a CB1 dependent hypothalamic connection to the lateral meniscus that prevents its mineralization and subsequent articular cartilage damage.
🔗 www.oarsijournal.com/article/S106...
🆕 Editor's Choice!
This month's featured paper is on plasma #lipoprotein and #osteoarthritis risk
Lipoprotein subclasses play diverse roles in health and disease there is so much more to learn about its impact on knee #osteoarthritis
Read more from Li et al - www.oarsijournal.com/article/S106...
LAST DAY TO SUBMIT!☺️
10.11.2025 12:49 — 👍 0 🔁 0 💬 0 📌 0
How did Zhou et al. monitor the temporal profiling of lipid mediators in the synovium and tibial plateau during joint inflammation🧐? Learn out this work in this month's #EditorsChoice paper for #Basic #Science.
🔗
www.sciencedirect.com/science/arti...
One week left to submit your #Cover #Art for the #OAC cover art competition. We look forward to seeing all of the creative designs. 🤩
03.11.2025 13:56 — 👍 3 🔁 1 💬 0 📌 1
👋 Are you a young researcher interested in editorial roles?
If that is you, OAC is currently seeking Editorial Fellows for 2026!
Fellows will be mentored by our Editors-in-chief David Hunter @jointsintheworld.bsky.social and our team of Deputy Editors.
form.jotform.com/242315596999...
#New research highlights the key role of the NGF/TrkA pathway in chronic #OA pain. Through gene expression analysis, specific genes and pathways linked to OA progression were found, offering insights for targeted therapies against OA pain. #PainResearch
📖:
www.sciencedirect.com/science/arti...
Think of transplanting stem cells like sending an athlete onto the field—without
training, they'll struggle. Ai et al. created a "warm-up" system that mechanically pre-trains
MSCs for the tough environment of the knee!
🔗https://www.sciencedirect.com/science/article/pii/S1063458425010659?via%3Dihub
Great summary of our latest work - a real Team Science effort! 👥 🐭
02.10.2025 19:11 — 👍 4 🔁 1 💬 0 📌 0