Osteoarthritis and Cartilage Journal

LAST DAY TO SUBMIT!☺️

How did Zhou et al. monitor the temporal profiling of lipid mediators in the synovium and tibial plateau during joint inflammation🧐? Learn out this work in this month's #EditorsChoice paper for #Basic #Science.
🔗
www.sciencedirect.com/science/arti...

One week left to submit your #Cover #Art for the #OAC cover art competition. We look forward to seeing all of the creative designs. 🤩

👋 Are you a young researcher interested in editorial roles?

If that is you, OAC is currently seeking Editorial Fellows for 2026!

Fellows will be mentored by our Editors-in-chief David Hunter @jointsintheworld.bsky.social and our team of Deputy Editors.

form.jotform.com/242315596999...

#New research highlights the key role of the NGF/TrkA pathway in chronic #OA pain. Through gene expression analysis, specific genes and pathways linked to OA progression were found, offering insights for targeted therapies against OA pain. #PainResearch
📖:
www.sciencedirect.com/science/arti...

Think of transplanting stem cells like sending an athlete onto the field—without
training, they'll struggle. Ai et al. created a "warm-up" system that mechanically pre-trains
MSCs for the tough environment of the knee!
🔗https://www.sciencedirect.com/science/article/pii/S1063458425010659?via%3Dihub

Great summary of our latest work - a real Team Science effort! 👥 🐭

Booster sessions for maintaining the effect of neuromuscular exercise and progressive resistance training in hip osteoarthritis: 12-month follow-up from a multicenter cluster-randomized controlled tri... Clinicaltrials.gov (NCT04714047).

Link to paper published in
@oacjournal.bsky.social here: pubmed.ncbi.nlm.nih.gov/40712915/

October's #EditorsChoice is on #guthealth

📈 Higher relative abundance of hashtag#alistipessenegalensis and alterations in tryptophan metabolites like indoleacrylic acid are associated with hand hashtag#osteoarthritis

✋ Access full-text and all their awesome figures here: lnkd.in/gPU3RNv7

The osteoarthritis associated sphingolipid sphingomyelin 34:1 causes inflammatory pain in mice Osteoarthritis (OA) has a multifactorial pathogenesis, pain being the main symptom driving clinical decision making. Dysregulation of multiple mediato…

www.sciencedirect.com/science/arti...

#New in #OAC ! The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid of those with OA. Work from @phar.cam.ac.uk shows that SM34:1 causes inflammatory pain in mice, inducing neuronal hyperexcitability.
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social

Are you a creative scientist?🧐
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
forms.gle/5qVWiHrHk2G9...

#New this month in #OAC . Translocator protein 18 kDa (TSPO) plays an important role in #OA occurrence and development. Emapunil targeting TSPO improves OA by modulating #macrophage polarization and #inflammation through the CD14/TLR4/LY96 pathway.
🔗
www.sciencedirect.com/science/arti...

#New in #OAC This study by Xiao et al. demonstrates that YAP plays a critical role in subchondral bone remodeling and targeting the YAP-Hhip axis through regulation of Hh-Gli1 signaling in Gli1+ osteogenic progenitors could inhibit OA progression! 🐭
www.sciencedirect.com/science/arti...

🌟 Four other conditions that should be considered in the differential diagnoses of early-stage symptomatic knee #osteoarthritis (EsSKOA)

1️⃣ Patellofemoral pain
2️⃣ Meniscus injuries
3️⃣ Collateral ligament injuries
4️⃣ Inflammatory arthritis

Read free at lnkd.in/gvKY77uB

Excited to be part of this guest editorial team: if you are looking for a home for your research on pain mechanisms in osteoarthritis, submit away 😃 #PainResearch

New from #OrACORe in @oacjournal.bsky.social: Longitudinal associations between bilateral vs unilateral knee osteoarthritis and physical performance. Contrary to our hypothesis we did not find associations between bilateral disease & worsening physical function
www.sciencedirect.com/science/arti...

Participants whose daily activity best matched patterns of high evening activity or very high morning activity had the least risk of developing #slowgaitspeed 🚶‍♂️

🗞️ Read more from Tore et al. oarsijournal.com/article/S1063-…

NEW in this month's issue 🔥

September's Editors Choice by Akkaya et al. found that diets rich in ultra-processed foods are linked to worse knee #osteoarthritis outcomes especially in women 🍔🍦🍟🍩

👀 Read about this large (n=4403) study for free at: www.oarsijournal.com/article/S106...

#BasicScience #EditorsChoice
This work by Liao et al. investigated the effects of Tamoxifen in multiple mouse models to better understand its role on bone and cartilage metabolism and endochondral ossification. 🐭
📖Read more:
www.oarsijournal.com/article/S106...

🌟 #New in #OAC 🌟
Curious to know how Piezo1 deletion protects against TMJOA?
Read this new work by Wang et al.
sciencedirect.com/science/arti...

📢 Call for Papers
OAC is excited to announce a Special Issue on Pain Mechanisms in Osteoarthritis.
www.sciencedirect.com/special-issu...
Submission Deadline: May 15th, 2026

#New #Basic #Science in #OAC
How does sex influence the development of #PTOA using a mouse model of mechanical #ACL injury? 📑Check out this work:
www.sciencedirect.com/science/arti...

Associations between total and regional fat-to-muscle mass ratio and osteoarthritis incidence: A prospective cohort study To investigate the associations between total and regional fat-to-muscle mass ratio (FMR) and incident osteoarthritis among adults.

Higher fat to muscle ratio (FMR) associated with higher #osteoarthritis incidence 👀 👇

🔢 Data from a large prospective cohort study from the UK Biobank dataset (n=328,549)

Read further in this month's issue from Lou et al.:

www.oarsijournal.com/article/S106...

Curious to know how to use #AI in #OAC? 🧐
elsevier.com/about/polici...

🔥 How can pharmacists help deliver high-value knee OA care?

📖 Explore the #Capabilities, #Opportunities, and #Motivations of Australian pharmacists in this new study: oarsijournal.com/article/S1063-…"

🎙️ New #jointaction podcast on all things #methotrexate

Joint David Hunter with guests Robin Christensen, BSc, MSc, PhD Anna Døssing to learn more 👇

Podcast link: www.jointaction.info/podcast/epis...

Editorial link: pubmed.ncbi.nlm.nih.gov/40222629/

New this month!

🦴 Calcium pyrophosphate deposition disease (CPPD) is associated with increased risk of fractures (Fig. 1 below 👇 )

www.oarsijournal.com/action/showP...

#August #EditorsChoice #BasicScience
This work by Zapata-Linares et al. uses a dynamic mouse model to assess the positive correlation between OA and increased bone marrow adiposity. 📖 more: www.sciencedirect.com/science/arti...

🏃‍♂️‍August's Editor's Choice is on #Taichi

✅ Several benefits associated with #Taichi in this 28 study systematic review that included 1676 OA participants

👀 Read more from Zhao et al. at www.oarsijournal.com/article/S106...