Wade-Martins Lab, University of Oxford

The @ukdri.ac.uk & Race Against Dementia have launched a bold new fellowship scheme to support the next generation of researchers using the latest AI technology to drive pioneering research

A reminder that the closing date to apply for the Research Assistant post is Friday 5th Sept 25 at 12noon. bit.ly/4lURYW9

In case you missed it, be sure to watch July's instalment of the Discover ASAP!

Ricardo Márquez Gómez from Wade-Martins Lab discussed their scalable microfluidic platform that enables the study of human neuron microcircuitry, connectivity, and regeneration in vitro 🔬

#OpenScience #PD #iPSCs

📣Job opportunity: We are seeking a Research Assistant neuronal cell biologist to join the lab @kavlioxford.bsky.social within @oxforddpag.bsky.social. You will be working on a translational research project investigating lysosomal dysfunction in #Parkinson’s disease. Job Details: bit.ly/4lURYW9

Opposite ACh changes with learning at cue and reward are signal component selective and spatially concentrated in the anterior dorsal striatum.

CRN Team Cragg used array photometry in mice to reveal a topography of opposing changes in ACh release across distinct striatal regions. Reward prediction error encoding was localized to specific phases of ACh dynamics in anterior dorsal striatum.

🔗 Read the full #publication: bit.ly/3JjqQCE

New insights into axonal regulators of dopamine transmission in health and disease Dopamine release in the striatum is credited with being critical to the selection and learning of motivated actions and outcomes. Dysregulation of str…

📣 New publication alert 📣

Check out our collaborative review on axonal molecular and circuit mechanisms governing dopamine exocytosis in health and PD. Congratulations to Kathryn Todd from Cragg Lab and Kaitlyn Cramb from Wade-Martins Lab for spearheading this publication!

Research Assistant: Lysosomal dysfunction in Parkinson’s Research Assistant, University of Oxford, Oxford, iPSC Parkinson’s project developing biomarkers and testing therapies on lysosomal dysfunction.

Research Assistant Vacancy, University of Oxford. Join a translational project on lysosomal dysfunction in Parkinson’s, using iPSC models to develop biomarkers and test therapies. Closing date: 5th September

www.dementiaresearcher.nihr.ac.uk/job/research...

Our Pilot Projects are open for application! This funding supports novel research ideas with the potential to lead to a major project or early-stage translational work with our Drug Discovery Alliance.

Applications close on October 15. Apply now: www.alzheimersresearchuk.org/grants/pilot...

@bcarlylegroup.bsky.social

We're kicking off our new series: Initiative Spotlight 🔦 starting with Aligning Science Across Parkinson's (ASAP)!

@asapresearch.parkinsonsroadmap.org aims to speed discovery and drive progress toward a #ParkinsonsDisease cure through collaboration and open science.

Learn more: bit.ly/3Ys7sIo

Help Shape Alzheimer’s Research UK Conference 2026 Help shape ARUK Conference 2026. Share your ideas on topics, formats, and more for the 24–25 Feb event in Manchester and online. Take the survey.

📢 Help shape the Alzheimer's Research UK Conference 2026! Share your ideas on topics, formats, and more for the 24–25 Feb event in Manchester & online @alzheimersresearchuk.org

www.dementiaresearcher.nihr.ac.uk/help-shape-a...

Higgins Group Awarded Gold LEAF Award for Sustainability Efforts

🌿 We’re delighted to share that Higgins Group at Kavli Oxford has been awarded a Gold LEAF Award!

Led by lab manager Hannah Ivison, the team has taken impressive steps to reduce waste, improve efficiency, and build a more sustainable lab.

One more Gold for #KavliOxford! ✨
tinyurl.com/ynceehdn

This month’s Discover ASAP features Ricardo Márquez Gómez of @craggasap.bsky.social, discussing a fluid-wall microfluidic platform to model human corticostriatal circuits 🧪

This platform enables axon studies, long-term culture, & scalable testing for #Parkinsons.

📺 youtu.be/dutY_mxext4

@kavlioxford.bsky.social avlioxford.bsky.social @dpagathenaswan.bsky.social enaswan.bsky.social @oxforddpag.bsky.social sky.social @medsci.ox.ac.uk sci.ox.ac.uk @oxfordpdcentre.bsky.social

🥳 We are celebrating achieving a LEAF Gold award for the 3rd year in a row! 🥳Thanks to everyone for their support in adhering to more sustainable practices. A special thank you to Feodora Bertherat for her tireless efforts & the extra work she puts in to help us achieve this.

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides SARM1 is a key regulator of a conserved program of axon degeneration increasingly linked to human neurodegenerative diseases. Pathological SARM1 activ…

#TuesdayReads:
The @WadeMartinsLab shows how antisense oligonucleotides targeting SARM1 protect human neurons from axon degeneration—highlighting a promising therapeutic approach for neurodegenerative disease.

🔗 www.sciencedirect.com/science/arti...

Initiating and persisting mechanisms of Parkinson’s neurodegeneration from environmental risk factors Dr. Briana De Miranda is a Neurotoxicologist and Assistant Professor of Neurology within the Killion Center for Neurodegeneration and Experimental Therapeutics at University of Alabama at Birmingham (...

Our thanks to Briana De Miranda‬ @bdemira.bsky.social who joined us online today to give a talk to the OPDC on Initiating & persisting mechanisms of #Parkinson’s #neurodegeneration from environmental risk factors. @kavlioxford.bsky.social @oxforddpag.bsky.social talks.ox.ac.uk/talks/id/061...

@dpagathenaswan.bsky.social @oxforddpag.bsky.social @kavlioxford.bsky.social

The award was given for building relationships with international karate clubs, for single-handedly organising an international university karate meeting, a first of its kind, and for obtaining a coaching license in order to be able to support and improve club training sessions.

Congratulations to DPhil student; Johanna Hoffmann, who was awarded a trophy and certificate for ‘Outstanding Contribution to Sport’ at the University’s Annual Sports Awards 2025 on 16th June held at Somerville College

The closing date for this position is fast approaching! Apply now to join the lab and no later than 30 June at 12 noon @kavlioxford.bsky.social @dpagathenaswan.bsky.social @oxforddpag.bsky.social
👇

🚨Job opportunity: We are seeking a Postdoctoral Research Scientist (Neuronal Cell Biology) to join the lab for 2 years @kavlioxford.bsky.social within @oxforddpag.bsky.social dpag.bsky.social. Closing Date: 30 June at 12:00. More info: bit.ly/3HTbwvB @oxneuro.bsky.social @oxfordpdcentre.bsky.social

Postdoc Research Assistant: Neuroimaging & Ultrasound Neuromodulation Join Oxford’s BNDU as a Postdoc Research Assistant to explore ultrasound neuromodulation for dementia-related symptoms in Parkinson’s disease patients.

Join Oxford’s BNDU as a Postdoc Research Assistant to explore ultrasound neuromodulation for dementia-related symptoms in Parkinson’s disease patients. Closing date: 16th July

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

OPDC hosts the 2025 Oxford Parkinson’s Research Day
@kavlioxford.bsky.social
dpag.ox.ac.uk/news/oxford-...
@oxforddpag.bsky.social @dpagathenaswan.bsky.social
@oxneuro.bsky.social @dunnschool.bsky.social @ndcnoxford.bsky.social @mrcbndu.ox.ac.uk

🚨Job opportunity: We are seeking a Postdoctoral Research Scientist (Neuronal Cell Biology) to join the lab for 2 years @kavlioxford.bsky.social within @oxforddpag.bsky.social dpag.bsky.social. Closing Date: 30 June at 12:00. More info: bit.ly/3HTbwvB @oxneuro.bsky.social @oxfordpdcentre.bsky.social

A huge thanks to Prof Kenneth S. Kosik for his wonderful OPDC seminar talk; The Knotty Problem of Neurofibrillary Tangles. We hope you & the Kosik Lab enjoyed your visit
@dunnschool.bsky.social @oxforddpag.bsky.social @kavlioxford.bsky.social @ucsantabarbara.bsky.social #alzheimers #stemcelltherapy

OPDC researchers support World Parkinson’s Day 2025

OPDC researchers support World Parkinson’s Day 2025 www.dpag.ox.ac.uk/news/opdc-re... @oxfordparkinsons.org.uk @oxforddpag.bsky.social @kavlioxford.bsky.social @parkinsons.org.uk

The ASAP CRN 2025 Collaborative Meeting gave us the opportunity to come together in person for an intense, inclusive, and inspiring experience. Always a pleasure to see everyone in person!

@stephcragg.bsky.social
@wademartinslab.bsky.social @meletis.bsky.social @asapresearch.parkinsonsroadmap.org

The ASAP CRN 2025 Collaborative Meeting was filled with wonderful talks. Many thanks to our PIs Steph, Richard, and Dinos for sharing the Team's findings with the CRN community!

@stephcragg.bsky.social @wademartinslab.bsky.social @meletis.bsky.social @asapresearch.parkinsonsroadmap.org