Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder This cohort study evaluates phenotypic and genetic heterogeneity in major depressive disorder.

📢 NEW RESEARCH: Why do some people respond to one antidepressant medication and not another?

A new paper used prescription data & genetic information from 12,000+ participants to test whether genetic differences distinguish patterns of antidepressant prescribing 👇

jamanetwork.com/journals/jam...

Figure 1 shows Antidepressant use in the Australian Genetics of Depression Study. Graph A depicts the number of participants using each antidepressant; Graph B shows the distribution of cumulative prescription duration for antidepressants.

Among adults with #Depression, complex antidepressant treatment patterns were associated with higher polygenic risk for psychiatric traits but not with sustained use of a single antidepressant. ja.ma/4k3LpkN

Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder This cohort study evaluates phenotypic and genetic heterogeneity in major depressive disorder.

New in @jamapsychiatry.com - in the Australian Genetics of Depression Study we show using 4.5 yrs of prescription data that genetic risk for ADHD, depression, neuroticism and bipolar disorder influence the complexity of an individual's depression treatment journey

jamanetwork.com/journals/jam...

Atypical depression is associated with a distinct clinical, neurobiological, treatment response and polygenic risk profile Atypical depression is considered a distinct clinical subtype of major depression, yet its predictive validity and clinical utility remain contested. We investigated association between atypical depre...

Our new paper in Biological Psychiatry #SOBP in 3,000 Australians with #atypical #depression (N=15K) links atypicality with poorer response to SSRIs and SNRIs + genetic risk for #metabolic, #inflammatory, and #circadian traits.

www.biologicalpsychiatryjournal.com/article/S000...

Atypical depression is associated with a distinct clinical, neurobiological, treatment response and polygenic risk profile Atypical depression is considered a distinct clinical subtype of major depression, yet its predictive validity and clinical utility remain contested. We investigated association between atypical depre...

Our new paper in Biological Psychiatry #SOBP in 3,000 Australians with #atypical #depression (N=15K) links atypicality with poorer response to SSRIs and SNRIs + genetic risk for #metabolic, #inflammatory, and #circadian traits.

www.biologicalpsychiatryjournal.com/article/S000...

More evidence linking #depression & #daylight 🌞

In 13,000 Australians with depression, more time in daylight was associated with better sleep and mental health (adjusting for genetic risk, season, etc)

#sleep #circadian #mentalhealth

bit.ly/4ei9th5

More evidence linking #depression & #daylight 🌞

In 13,000 Australians with depression, more time in daylight was associated with better sleep and mental health (adjusting for genetic risk, season, etc)

#sleep #circadian #mentalhealth

bit.ly/4ei9th5

Views of international experts on challenges to early intervention for bipolar disorder Click on the article title to read more.

Grateful to have played a small part in this letter published in World Psychiatry

We identify 9 challenges to advancing early intervention in #bipolardisorders and hope to galvanise action on these issues

onlinelibrary.wiley.com/doi/10.1002/...

Views of international experts on challenges to early intervention for bipolar disorder Click on the article title to read more.

Grateful to have played a small part in this letter published in World Psychiatry

We identify 9 challenges to advancing early intervention in #bipolardisorders and hope to galvanise action on these issues

onlinelibrary.wiley.com/doi/10.1002/...

Twenty-four-hour Skin Temperature Rhythms in Young People With Emerging Mood Disorders: Relationships With Illness Subtypes and Clinical Stage - Mirim Shin, Joanne S. Carpenter, Shin H. Park, Connie J... While circadian disruptions are common in some sub-groups of youth with mood disorders, skin temperature rhythms in these cohorts are understudied. We examined ...

Wearables can detect skin temperature dysrhythmias in young people with mood disorders 🌡️

@brainandmindcentre.bsky.social @ucsandiego.bsky.social @isbd4.bsky.social @smhr.org.au @circadianmhnetw.bsky.social

journals.sagepub.com/doi/10.1177/...

#circadian #bipolardisorder #depression

Twenty-four-hour Skin Temperature Rhythms in Young People With Emerging Mood Disorders: Relationships With Illness Subtypes and Clinical Stage - Mirim Shin, Joanne S. Carpenter, Shin H. Park, Connie J... While circadian disruptions are common in some sub-groups of youth with mood disorders, skin temperature rhythms in these cohorts are understudied. We examined ...

Wearables can detect skin temperature dysrhythmias in young people with mood disorders 🌡️

@brainandmindcentre.bsky.social @ucsandiego.bsky.social @isbd4.bsky.social @smhr.org.au @circadianmhnetw.bsky.social

journals.sagepub.com/doi/10.1177/...

#circadian #bipolardisorder #depression