Mattia Frontini

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?

Yes, one can. with CUT&ID ✂️🪪

Spearheaded — singlehandedly — by @annanordin.bsky.social

No need of transgenesis, cloning and overexpression.

Check it out, it's fast and its works.

Kids born the same year that the term “RNA-seq” was coined are heading to college this fall. We are all unspeakably ancient.

Join our seminar next Tuesday, for two insightful talks from Julianne Funk and Nisha D. Kamath with powerful illustrations of how systematic variant characterization is accelerating precision medicine and expanding our therapeutic toolkit.

#Genomics #CRISPR #Seminar #AtlasOfVariantEffect

White background with a pixel map of Australia and text saying 1 month to go and program now available for the MSS 2026 meeting in Melbourne, Australia from25-27 March.

One month to go until we open the doors on #MSS26 and we can't wait to see you there! Check out the program and register at: www.mss2026.org

#MSS26 #MAVE #Genomics #PrecisionMedicine #Symposium #AtlasOfVariantEffectsAlliance

Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

We've got two exciting chromatin talks coming up on Wednesday next week:

@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!

register and join us: us06web.zoom.us/webinar/regi...

Ad for a postdoc position in centromere biology with colorful chromosomes and centromeres made out of FIMO.

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

🚨 Applications open! 🚨

Medical students: Apply for our 8-week Summer Scholarship in medical mycology. Gain lab experience, study design & data analysis skills, no prior expertise needed!

📍 Exeter or partner institutions
📅 Deadline: 28 Feb 2026
👉 buff.ly/PrpeVN4

🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...

Hope the dog won;t eat this one as well! Late buyer, missed the launch.

Pulse - Application Application The second SciLifeLab PULSE call is open (since December 15, 2025, at 11:00 UTC +1) PULSE postdoc applicants have the opportunity to choose between an academic or an entrepreneurial […]

You wish to do a #Postdoc supported by a unique network?

My Lab will host PULSE #Postdoc Applicants
Program by the prestigious @scilifelab.se

Check this out and get in touch with me if you are interested in top-notch #Genomics, #DevBio and #Cancer Biology 👇

www.scilifelab.se/research/pul...

🚨New paper out! In our @MolCellNews paper, we solve a piece of the puzzle of how our genome folds. We found the two specific molecular "brakes" in the CTCF protein that stop DNA loop extrusion. One of the final pieces of my PhD!
tinyurl.com/29uuc5by

Our new study defines a distinct #neurogenetic condition arising from recurrent structural variants at 16p13.3 palindrome.

Individuals show progressive ataxia, cognitive decline, and a characteristic MRI pattern with caudate & cerebellar atrophy.

#Genomics #RareDisease 🧵1/3

In ~5 hours…

Our latest work dissecting the interplay of endothelial and immune cells in non-communicable diseases genetics. We explained 815 loci (29% to 40%) and revealed the complex relationship between cell types and diseases.
www.biorxiv.org/content/10.1...
@nicolesoranzo.bsky.social @npirastu.bsky.social

Small things matter: Lack of extraislet β cells in type 1 diabetes Early loss of small extraislet β cells in children with type 1 diabetes could explain age-related differences in disease.

Congratulations to @sarahibex.bsky.social and Team at the University of Exeter Medical school (@hls.exeter.ac.uk) on the breakthrough study on #diabetes pathology

www.science.org/doi/10.1126/...

Please repost - Multiple PhDs available

www.findaphd.com/phds/project...

www.findaphd.com/phds/project...

www.findaphd.com/phds/project...

both are right: the best is marine microbiology

Reminder! Deadline to apply is midday today!

Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...

Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?

Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...

Enhancer-promoter compatibility is mediated by the promoter-proximal region Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...

What is a promoter? And how does it work?

We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters

www.biorxiv.org/content/10.1...

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...

A quick heads-up that we will have two PhD positions available to start in October 2026. One as part of MRC LMS PhD programme, and one as a transdisciplinary studentship with @srinjan.bsky.social and Thomas Ouldridge at Imperial.

mark all as read

🗣️ "You can get test kits sent to you - it's discreet and quick and easy."

Jack Fitzwater is supporting Royal Devon NHS's RAPID-IBD study 👊

FREE testing kits are available for EX postcode volunteers aged 16–49 ➡️ bit.ly/IBDKit

#ECFC #SemperFidelis

Very much looking forward to @axelvisel.bsky.social's talk "From Nucleotide to Megabase Scale: Enhancer Function in Development and Disease" in our @enhancedgenomics.bsky.social seminar series "The 3D Regulatory Genome"

📅 02 October 2025 (today!)
⏰ 4 pm GMT

Join:
us02web.zoom.us/webinar/regi...

nice to see this coming together with previous work on RNA pol II factories

Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which thi...

As we wait for the final version in the journal, I leave here the last version that we uploaded on bioarchive.
I hope you like it!

www.biorxiv.org/content/10.1...

Next up! Two applications of MAVE!
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (‪@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.