Adrian Jacobo

Thank you for the shout-out! This is the thesis work of the brilliant @emilyatlas.bsky.social in Jim's lab. Sadly, Jim passed away before the work was finished, but his mentorship lives on in this work.

Give it a read! A big shout out to Nico, Brian, Sihao, Yuri, Caleb, and Holland. And to Jim, who is always in our hearts.

When several neuromasts are stimulated simultaneously, these patterns are encoded sparsely, and neurons separate patterns through nonlinear integration.

He found that neuromasts show no topographic organization in the hindbrain, yet neurons are highly discriminative of stimuli.

Nico and Brian built a single-objective lightsheet microscope along with an offset stimulation arm. That allowed Nico to play the lateral line "like a piano" and stimulate any combination of neuromasts he wanted.

It's also my first paper in Systems Neuroscience! So it was quite a ride!

Optogenetic interrogation of the zebrafish lateral line reveals brain-wide neural circuits involved in pattern separation Zoology; Neuroscience; Sensory neuroscience

It's finally out! Our paper on optogenetic interrogation of the lateral line: www.cell.com/iscience/ful...
This one involved a lot of sweat and tears, and it was a real tour de force. It was also the last paper we got to write with Jim, so it's a special one (and hence, the tears).

Group photo of Workshop attendees

Thank you to organisers Alex Dunn, @zevgartner.bsky.social, @adrianjacobo.bsky.social and Matthew Kutys and everyone who joined us for our Workshop on New Technologies for Studying and Reprogramming Development.
#BiologistsWorkshops
biologists.com/workshops

PSA: around 5-8% of the population has a color vision impairment for red/green.

Many talks at #2025ICDB still use red-green LUTs on slides that are not accessible to everyone.

Changing to more accessible colors is doable and easy.

We can do better.
#devbio
#ICDB2025 #WeTheColorBlind

Website is now open for registration and abstract submission! See you in beautiful SLO! 😎🏖️ www.sdbonline.org/wcsdb2025

A. Neuromast of a live zehrafish larva. This is the first neuromast ipsilateralof the dorsal line viewed with Nomarski optics. Kinocilia (K) project into a gelatinous cupula (C) from hair cells (HC). Credit to Metcalfe et al. 1985

Composite drawing of labeled efferent and afferent neurons. HRP was applied to a lesion of the midbody line branch of the right posteriorlateral line nerve (PLLn). The Irsim did not include the dorsal (D) oroccipital(0) branches. Labeled affercnt neurons of the posterior lateral lineganglion (PLLg) terminate in the hir:dbrain (PLLt). Three types of neurons (RELL, ROLE, and DELL) project axons into the posterior lateral line nerve. Only a single cell of each type is shown. This is a composite drawing traced from two preparations sectioned in the horizontal plane. Scale bar = 50 um

Published 40 years ago, Metcalfe et al. were first to fully characterize the lateral line (a series of sense organs on skin that detect water flow) in #zebrafish larvae. Included within this seminal piece are meticulous hand-drawings that are commonly found in Kimmel's papers. #ZebrafishFunFacts 🧪

Workshop New Technologies for Studying and Reprogramming Development Organisers: Alex Dunn, Zev Gartner, Adrian Jacobo and Matthew Kutys Early-career researchers apply for funded places 16-19 November 2025 Buxted Park, East Sussex, UK

One month left for ECRs to apply for a funded place at our Workshop 'New Technologies for Studying and Reprogramming Development' organised by Alex Dunn,
@zevgartner.bsky.social , @adrianjacobo.bsky.social and Matthew Kutys.
📆Apply by 23 May
biologists.com/workshops/no...
#BiologistsWorkshops

Flyer for the 2025 Next Generation Faculty Symposium (including QR code in top right corner). This symposium highlights the work of exceptional early-career scientists in the broad field of quantitative biological and biomedical sciences, with a track record of excellence in research, leadership, mentorship, and community engagement. These early career scientists are preparing to launch a faculty search. Applications are due May 30th, 2025.

Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

This role sits at the intersection of molecular biology, advanced microscopy, and computational analysis.
Ideal candidates have a recent PhD and strong expertise in FISH techniques, RNA handling, and probe design. Join us in creating comprehensive spatial maps of developing vertebrate organisms!

Scientist, Spatial Molecular Cartography (Jacobo/Royer Group - Biohub SF) San Francisco, California, United States

🧬🔬🧪 We are seeking a Scientist to push the limits of spatial transcriptomics in zebrafish! Come join us!
#MolBio #SpatialTranscriptomics #DevelopmentalBiology #ScienceJobs 🧫🐟🔍

job-boards.greenhouse.io/chanzuckerbe...

Workshop New Technologies for Studying and Reprogramming Development Organisers: Alex Dunn, Zev Gartner, Adrian Jacobo and Matthew Kutys Early-career researchers apply for funded places 16-19 November 2025 Buxted Park, East Sussex, UK

Early-career researchers can apply for a funded place at our Workshop 'New Technologies for Studying and Reprogramming Development' organised by Alex Dunn,
@zevgartner.bsky.social , @adrianjacobo.bsky.social and Matthew Kutys.
📆Apply by 23 May
biologists.com/workshops/no...
#BiologistsWorkshops

You say port, I say backdoor, tomeito, tomahto

Ese es el puerto que usa el gobierno chino para espiarte

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.

Please amplify. If you are also able to host fly strains, add your name as well.

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No es un loop, es una espiral descendiente!

Did they miss the part when neoliberals in the 70s and 80s where right-wing fascists supporting every dictatorship that would implement their economic wet dreams?

Yo me sentí en casa cuando el tipo tuvo que aclarar 3 veces que no iban a dejar subir a nadie en un grupo que no fuera el suyo.

Estaremos en el mismo vuelo? MIA - EZE?

We have a new opening! Amazing environment colleagues and facility! Join us!

I have so many questions...

Vamos la Acadé! 😄

Sunny San Diego view

Happy to be in sunny☀️San Diego for ASCB Cell Bio! Tomorrow I will present #Ultrack and #inTRACKtive (poster B513) at 11:15 am. Swing by the CZI+@czbiohub.bsky.social
booth (#119) for live demos of these tools + #napari & #zebrahub 🐠 Looking forward to connect!🤩🧪🔬

#CellBio2024 #ASCB24 #celltracking