Jay Hinton

📈 Reported cases of non-typhoidal Salmonella in England rose by 17% — from 8,872 in 2023 to 10,388 in 2024.

Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars

www.gov.uk/government/p...

Welcome to Liverpool Tanya ❗️

LSTM welcomes three leading global health therapeutics experts with support from UKRI Dr Jeremy Burrows, Professor Tanya Parish, and Dr Ami Patel will bring unique expertise in medicinal chemistry, drug discovery, vaccinology and antibody-based therapeutics into LSTM, enhancing its

My news is that I will be joining the Liverpool School of Tropical Medicine! I'm very excited to join an organization that shares my passion for improving global health, at the same time I'm sad to leave all of the wonderful colleagues here at SCRI who I've enjoyed working with over the past ~6y 🦠🧪

Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky
www.shigella2026.conferences-pasteur.org/home

The @microbiologysociety.org champions got together and talked about their fave #microbes on international microorganism day.

So I did a few more portraits of the little legends!

I will hopefully repost them all with alt text over the next few weeks

#sciart #microsky 🧪

Use of genome-scale metabolic reconstructions of avian pathogenic Escherichia coli (APEC) phylogroups for the identification of lineage-specific metabolic pathways Avian pathogenic Escherichia coli (APEC) are a genetically diverse pathotype primarily associated with extra-intestinal infections in birds. APEC lineages are predicted to have unique metabolic capabi...

www.microbiologyresearch.org/content/jour...
It is out! Our paper from the PhD work of Huijun Long, constructing and analysing metabolic models of Avian Pathogenic E. coli ( #APEC ) in Mgen @microbiologysociety.org

With @jaimehat.bsky.social and @roblaragione.bsky.social #microsky #idsky

On this week, 40 years ago, my friend Ralph Isberg, then a postdoc with Stan Falkow, reported the discovery of the 1st invasin gene in @nature.com "We report here the identification of a single genetic locus from this organism (Y. pseudotuberculosis) that is sufficient to convert the innocuous

We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded.

Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!

A family of six gathered around an island in a kitchen with food on it.

✅ Live in England? 📍

✅ Are several members of your family willing to give a stool sample? 👪

You can take part in our PEARL-AGE study understanding how microbes are shared within families.

➡️ buff.ly/3B9QJkh

@earlhaminst.bsky.social

The Guardian view on university finances: stop chipping away at a crumbling system | Editorial Editorial: Economic and academic activity are bound up together. Charging international students more for less will not fix deep-seated problems

Crisis at England universities created by successive govts.

Freeze on student fees
Real cuts in govt grants
Harder to enrol foreign students
Home student numbers falling
£267bn student debt
Real wage cuts
40% of universities in trouble.

Local economies decline with university decline

A plasmid golden ratio? 🧬
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky

Honored to have received the 2026 ASM Award for Early Career Basic Research. This award is also a recognition of my phenomenal trainees and their hard work. Thank you to the mentors that have supported my career and those who have nominated me for this award.

asm.org/press-releas...

Delighted with our new paper on a novel itaconate transporter in the human pathogen Pseudomonas aeruginosa, led by Javeria and Reyme. @ybri-uoy.bsky.social @javeriamehboob.bsky.social @bethkw.bsky.social A duplicated transporter on its way to itaconate selectivity
portlandpress.com/biochemj/art...

This was a slow burn being a side project of a side project - started with chats with @jayhinton.bsky.social about itaconate in Salmonella and then picked up a my PhD students & undergraduate project students working together to finish a cool story - what a team!

DNA methylation influences human centromere positioning and function - Nature Genetics Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

Focusing on something other than Salmonella for a minute, because my wife’s paper is just out and it is AMAZING! www.nature.com/articles/s41...

Congrats to all the authors, great work from the @dfachinetti.bsky.social @naltemose.bsky.social labs!

Eurasian Jay for #ThursJay

Photographed at Brown Moss Nature Reserve near Whitchurch, Shropshire on #Kodachrome in the mid-1980s.

#EastCoastKin #PhotoHour #birds #birdphotography #nature #wildlife

Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham Looking for a new job opportunity in academia? Check out this job opening for a Assistant Professor (Research and Education) in Bacterial Genomics on jobs.ac.uk!

Assistant Prof post in bacterial genomics @unibirmingham.bsky.social Come and join us!!

@imibirmingham.bsky.social
www.jobs.ac.uk/job/DOO184/a...

Frontiers | Bacteriophages against Salmonella enterica: challenges and opportunities Salmonella spp. is the most common pathogen transmitted to humans through contaminated water and food. Due to its ability to infect both animals and humans, ...

Bacteriophages against Salmonella enterica: challenges and opportunities

#phage #phagesky

www.frontiersin.org/journals/bio...

“Don’t trust the experts” is an absurd thing to say because we all have to trust experts in many aspects of daily life. The real questions are what defines an expert, how do you recognize them, how to distinguish them from crackpots, and what to do when expert opinions disagree.

Genetic Evidence of Yersinia pestis from the First Pandemic www.mdpi.com/3429378 #mdpigenes

Clinical metagenomics for diagnosis and surveillance of viral pathogens Nature Reviews Microbiology, Published online: 13 August 2025; doi:10.1038/s41579-025-01223-5Metagenomics approaches are being increasingly used for the diagnosis of viral infections, outbreak investigation, and new and emerging pathogen surveillance. This Review highlights sequencing approaches and technologies, discusses their applications in diagnostics, surveillance and virus discovery, and outlines future perspectives for the field.

New online! Clinical metagenomics for diagnosis and surveillance of viral pathogens

Cartoon of a rod shaped bacterium, wearing a spotty shower cap, holding a towel. Flagella are falling out of the shower cap and its expression is one of tired watchful waiting. The writing spells the bacterium's name, Serratia marcescens. The background is light, with mottled pink and blue abstract textures.

A new pathogen portrait: Serratia marcescens... which is opportunistic and likes to hang out in hospitals. Find out more about Serratia here:
en.wikipedia.org/wiki/Serrati...

I'm looking for friendlier microbes to draw from time to time too - do let me know if any occur to you!
🐡🧪🔬

New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with @kamovalenz.bsky.social
and @joaquinbernal.bsky.social : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV

A Salmonella T3SS-2 mutant grows fine in spleen macrophages, contradicting tissue culture dogma (PMID: 23236281). This observation was largely ignored, but adding certain carbon sources rescues growth in cultured macrophages, hinting that T3SS-2 may be doing something entirely different in vivo.

Unlocking genetic potential: harnessing phage for targeted mutagenesis in phage-assisted evolution Abstract. A critical challenge in DNA library genesis for evolution systems is avoiding off-target mutations, which can introduce undesirable changes elsew

#phage #phagesky #microsky

academic.oup.com/nar/article/...

Massive thanks to the phenomenal co-first authors @1caiseypulford and @blancaps.bsky.social‬ and especially to one of my favourite scientists to work with, co-corresponding author and fellow history fanatic @weill_xavier 10/n

S. Panama causes major disease concerns, including high rates of iNTS in French Guiana, large outbreaks in European pork, AMR in Asia, and outbreaks in American soldiers from where the first (extant) isolate from 1931 came from (More in our 2019 review: 10.1128/IAI.00273-19) 2/n

There are half a million cases of invasive non-Typhoidal Salmonella (iNTS) every year and while you might know S. Typhimurim and Enteritidis, you may not have heard of S. Panama 💩 🩸 🧫 💊 Check out our latest in @lancetmicrobe.bsky.social doi.org/10.1016/j.la... and the 🧵 below to find out more 1/n

Metagenomic selections reveal diverse antiphage defenses in human and environmental microbiomes Rodríguez-Rodríguez et al. use functional metagenomics to identify hundreds of sequences from diverse environmental bacteria that block phage infection when expressed in E. coli. Their discoveries inc...

The diversity of bacterial defence systems against phages (restriction endonuclease, #CRISPR, phage protein
sensing system (RexAB), cyclic oligonucleotide-based (CBASS), ADP ribosylation (DARTG)) is simply fascinating, and we continue to discover new ones !!!

www.cell.com/cell-host-mi...

It was great fun writing this review with @gemccallum.bsky.social , even if our conclusions are rather scary. Lots of important pathogen evolution must be occurring outside of the infection context...