Adolfo Poma Bernaola

A Comparative Nanomechanical Study of Antibody and Nanobody Binding to SARS-CoV-2 Variants The receptor-binding domain of the SARS-CoV-2 spike protein is the principal target of neutralizing antibodies (Abs) and nanobodies (Nbs). Although their thermodynamic binding properties have been ext...

🚨 Preprint! Our work complements affinity studies for antibodies (Ab) design
🔹 Mechano­stability as design criterion for Abs against viral escape.
🔹 Two-chain topology: H chain bears force, L chain reinforces via inter-chain contacts.
Great work by @fcofas.bsky.social www.biorxiv.org/cgi/content/...

29.09.2025 07:36 — 👍 3    🔁 1    💬 0    📌 0

Congrats for the award and for pushing boundaries in molecular simulations !!!

24.09.2025 06:08 — 👍 1    🔁 0    💬 0    📌 0

Today our team member @fcofas.bsky.social is attending this @cecamevents.bsky.social organised in Sardegna: The Dual Nature of Glycans in Protein-Protein Interactions: Bridging Computational and Experimental Insights.
Thanks to @ncn.gov.pl for this great support!

07.09.2025 17:30 — 👍 5    🔁 0    💬 0    📌 0

Totally agree! Transient contacts cane help to understand such complex problem.

27.08.2025 21:21 — 👍 0    🔁 0    💬 0    📌 0

We depict the different proteases, apart from TMPRSS2, that can cleave the S protein, especially in relation to evolutionary adaptation.

🚨 "Evolution of the SARS-CoV-2 Spike Protein in Utilizing Host Transmembrane Serine Proteases"
🔬 How variants exploit more than just TMPRSS2 to enter cells.
Big thanks to @kpyrc.bsky.social team for this partnership 😎.
📄 Read: doi.org/10.1016/j.is... now in @cp-iscience.bsky.social

25.08.2025 21:14 — 👍 1    🔁 0    💬 0    📌 0