Adolfo Poma

The Frankfurt Institute for Advanced Studies (FIAS) and the newly funded Cluster of Excellence SCALE are seeking several Independent Research Group Leaders to drive theoretical and computational research in molecular and cellular life science.

fias.institute/de/das-fias/...

A personal journey through academia as a neurodiverse scientist | EMBO reports EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Discussing my personal experiences navigating neurodiversity in academia, and what worked for me to cope better in my latest column for EMBO Reports. Please share with anyone who might find this useful/helpful. You are not alone.

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Well, making the whole AI diagnosis into several smaller processes, each one functioning as a control step, seems more trustworthy at least to human specialists. And yes, medical doctors can be trained to interpret each AI stage and still rely on the final AI and doctor diagnosis.

Beautiful dynamic matching of protein complexes and their interfaces. I wonder if having a more flexible model for proteins that enables some conformational changes like GōMartini 3 can enable to see other bindings events. Safe to say that EN is the first approach for such binding processes.

Happy to share the latest work from the lab, led by @mudgal17.bsky.social‬, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)

🚀 New preprint!
We present an optimized contact map protocol for GōMartini 3 protein-assembly simulations.
🔹 Uses high-freq contacts from MD
🔹 Cuts contact sets by ~20–30% while keeping stability
🔹 Improves exploration of metastable states (e.g. SARS-CoV-2 spike)
Preprint: doi.org/10.1101/2025...

A Comparative Nanomechanical Study of Antibody and Nanobody Binding to SARS-CoV-2 Variants The receptor-binding domain of the SARS-CoV-2 spike protein is the principal target of neutralizing antibodies (Abs) and nanobodies (Nbs). Although their thermodynamic binding properties have been ext...

🚨 Preprint! Our work complements affinity studies for antibodies (Ab) design
🔹 Mechano­stability as design criterion for Abs against viral escape.
🔹 Two-chain topology: H chain bears force, L chain reinforces via inter-chain contacts.
Great work by @fcofas.bsky.social www.biorxiv.org/cgi/content/...

Congrats for the award and for pushing boundaries in molecular simulations !!!

Today our team member @fcofas.bsky.social is attending this @cecamevents.bsky.social organised in Sardegna: The Dual Nature of Glycans in Protein-Protein Interactions: Bridging Computational and Experimental Insights.
Thanks to @ncn.gov.pl for this great support!

Totally agree! Transient contacts cane help to understand such complex problem.

We depict the different proteases, apart from TMPRSS2, that can cleave the S protein, especially in relation to evolutionary adaptation.

🚨 "Evolution of the SARS-CoV-2 Spike Protein in Utilizing Host Transmembrane Serine Proteases"
🔬 How variants exploit more than just TMPRSS2 to enter cells.
Big thanks to @kpyrc.bsky.social team for this partnership 😎.
📄 Read: doi.org/10.1016/j.is... now in @cp-iscience.bsky.social