Gaetano Gargiulo

Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...

Very excited to see our new study out today - just in time for my talk annual EACR conference @helloeacr.bsky.social

🚨We want your abstract! Submit your Late Breaking Abstract to #EANO2025 by June 25, 2025 to become an essential part of the state-of-the art scientific programme. 👉 Learn more: eano.eu/eano2025/abs... #NeuroOncology #NeuroSurgery #cancernurse #braintumor #btsm

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...

first post on bluesky, and it's a big one: our single-cell study on ETMR, a terrible brain tumor that occurs in young children, now out in @natcancer.nature.com: www.nature.com/articles/s43.... tremendous effort by @alexbeck, @lisagblr.bsky.social and many others. please check it out!

Glad to see this out, very helpful resource for the community!

Thanks for the invite, Alex! I really enjoyed both the chance to give a talk and the uniquely Swedish welcome, w/two Malmö goals included. Big relief I didn’t jinx it! 😅

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity

www.nature.com/articles/s41...

Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...

"EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!

Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...

Understanding the basics is key to developing effective treatments. This framework on the myeloid side of brain tumors offers a systematic POV, with the dexa angle being particularly intriguing.

“We are almost ready for the test flight. All we need is the license." ...in Germany that may take much longer than developing and building the rocket 😂

🤣🤣🤣

Above all, I find it incredibly inspiring that a scientist with four decades of groundbreaking work is still leading discoveries, firsthand, literally. For some, curiosity and rigor never age. This one is special 👏

RNA polymerase II at histone genes predicts outcome in human cancer Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...

Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution.

@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...

🔬 #FundamentalResearch is key for #EUcompetitiveness

Someone finally said it out loud.

Amazing

Normalize calling Republicans Nazis.

Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...

1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.

Injectable fluorescent retro-tracing of pancreatic cancer innervation. Denervation sensitizes PDAC to immunotherapy by counteracting neuronal suppression of acute inflammation in CAFs. Plus, tumor denervation as a novel mechanism behind the old nab-paclitaxel combo. Quite a characterization indeed!

congrats Victor! Looking forward to reading it!

Cell identity lives from constraints and dies from freedom

Who knew they’d give you more than cavities? 😅 - great to see this on the cover @GuccioneLab!

Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes - Nature Communications Descriptive data in biomedical research are expanding rapidly, but functional validation methods lag behind. Here, authors present Logical Synthetic cis-regulatory DNA, a framework to design reporters...

the synthetic locus control region for this study was designed using www.nature.com/articles/s41...

Proud to see our lab’s work contribute to this fantastic study, and specifically: "[...]We have recently developed a new strategy to genetically trace cell fate transitions within a heterogeneous tissue37,38 [...]" Check it out! 👇

1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...

Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social

Now online in Cancer Discovery: PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State - by Shane Killarney, Kris Wood and colleagues doi.org/10.1158/2159...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...

Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13

onlinelibrary.wiley.com/doi/10.1111/...