NanoImaging Services

How do you choose a nanoparticle characterization method? While there are many techniques available, cryo-TEM stands out by revealing information other methods miss.

Dive into the comparison: www.nanoimagingservices.com/about/blog/v...

Ever wondered how buffers impact #cryoEM structures?

🧪 DMSO and cryoprotectants can be tolerated at low concentrations. If you're curious if your buffer will be compatible, schedule a call with our experts: www.nanoimagingservices.com/contact

Are you looking for comprehensive, reliable particle sizing analysis? From LNPs to iron nanoparticles, cryo-TEM semi-automated particle contouring and sizing provides precise particle size distribution measurement for a range of samples.

Learn more at www.nanoimagingservices.com/nanoparticle...

🧪 Ever wondered what the difference is between #cryoEM and #negativestain #TEM is? Find out in today's FAQ Friday!

Join Dr. Mandy Janssen, Scientific Director of Characterization at NIS, to:- Discover how cryo-TEM enables high-resolution visualization of individual LNPs i... Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Do you know how #LNPs show up in #cryoTEM versus negative stain TEM?

Want to learn more about the advantages of cryo-TEM for LNPs and other #liposomal samples? Tune in for the full webinar from Dr. Maria (Mandy) Janssen:

During a recent webinar, we were asked, “How does automated cryo-TEM particle picking for AAV full/empty capsids compare to other orthogonal methods?”

Watch the webinar in full for a great explanation of cryo-TEM imaging & analysis of AAV, and more of your great questions: youtu.be/w7kRfNZX_SI

Poor contrast TEM images got you feeling grey? No problem!

Our latest tutorial will help you quickly & easily enhance the contrast and add scale bars to your #cryoTEM or negative stain TEM images so they’re ready for publication:
www.nanoimagingservices.com/about/blog/e...

Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Did you miss our webinar last week? You can now catch this amazing talk from Dr. Mandy Janssen about #cryoTEM #LNP characterization, NIS’s proprietary AI tools for image analysis, and a case study showing unique insights only cryo-TEM can provide.

Catch it here:

Unlocking the Secrets of RNA: Protein-Free Structure Determination w/ Cryo-EM Unlock the secrets of RNA molecules with cryo-EM. High resolution data collection & structure determination with cryo-EM for structure based drug discovery at NIS.

Are you struggling to solve the structure of your #RNA molecule? Cryo-EM study RNA in its native, unbound state, without the influence of associated proteins?

Learn more about the potential of #cryoEM single particle analysis for protein-free RNA: www.nanoimagingservices.com/about/blog/u...

Unexpected results in your #LNP formulations? Join our webinar + Q&A to learn how #cryoTEM imaging can help provide answers.

We will reveal how cryo-TEM can provide reliable, reproducible data (size, morphology, lamellarity, blebs) in one dataset.

Sign up: nimgs.zoom.us/webinar/regi...

Have you signed up yet? In just 1 week, Dr. Mandy Janssen will be giving a webinar + Q&A diving into the applications of #cryoTEM for #LNP development!

Don't miss out on this deep dive: nimgs.zoom.us/webinar/regi...

Can't make it live? Sign up to get a recording, or send in your questions!

FAQ Friday! Dr. Sarah Strassler Sulley touches on the differences between cryo-EM and HDX for epitop emapping.

Want more? Check out our blog with an in-depth technique comparison: www.nanoimagingservices.com/about/blog/e...

Looking for ways to enhance your #LNP analysis tools?

Dr. Mandy Janssen will present how #cryoTEM imaging & automated analysis can reveal multiple CQAs all in one dataset.

Questions? Stick around after the webinar for a Q&A with Mandy.

Sign up: nimgs.zoom.us/webinar/regi...

How big are cryo-EM grids exactly? Find out!

It's tomorrow! Join us to learn about automated cryo-TEM analysis of AAV full/empty capsid ratios.

Can't make it? Sign up anyway to receive a recording.

Don't miss this webinar + Q&A session: nimgs.zoom.us/webinar/regi...

Webinar! Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Enable high-resolution visualization of LNPs in near-native state, analyze multiple CQAs in 1 dataset, & use automated image analysis tools for quantitative measurements.

Register: nimgs.zoom.us/webinar/regi...

One week out! Join us for a webinar, "Automated Cryo-TEM Analysis of AAV Empty/Full Capsid Ratios".

Whether you're troubleshooting or aiming to streamline AAV manufacturing process, we'll demonstrate how cryo-TEM can drive faster informed decisions.

Sign up: nimgs.zoom.us/webinar/regi...

Welcome! You are invited to join a webinar: Automated Cryo-TEM Analysis of AAV Empty/Full Capsid Ratios. After registering, you will receive a confirmation email about joining the webinar. Join Dr. Eric Bushong, Principal Scientist, for a 30 minute webinar followed by live Q&A. - Explore the advantages of cryo-TEM for characterizing AAV formulations - See how empty/full capsids are qu...

Don't miss this webinar! "Automated Cryo-TEM Analysis of AAV Empty/Full Capsid Ratios" on 5/15, 11am PST, 2pm EST.

Whether you're troubleshooting or aiming to streamline AAV manufacturing process, we'll demonstrate how cryo-TEM can drive faster informed decisions.

nimgs.zoom.us/webinar/regi...

Welcome! You are invited to join a webinar: Quantitative Empty/Full Analysis of AAV Capsids Using Cryo-TEM. After registering, you will receive a confirmation email about joining the webinar. Join Dr. Eric Bushong, Principal Scientist, for a 30 minute webinar followed by live Q&A. - The advantages of the cryo-TEM approach for assessing AAV formulations - How AAV empty/full capsid status ...

Live webinar! Learn about automated AAV empty/full capsid ratio analysis with cryo-TEM on Thursday May 15, 11am PST, 2pm EST.

Learn the advantages of cryoTEM for assessing AAV formulations & how AAV empty/full capsid status is determined.

Sign up: nimgs.zoom.us/webinar/regi...

What are sample size requirements for Single Particle Analysis cryo-EM? Join Dr. Sarah Strassler Sulley to find out!

Questions about cryo-EM? Let us know!

Did you know cryo-TEM is the only technique that can visualize blebbing on LNPs?

Check out our latest blog for detailed examples of blebs & bilayers, and a literature review: bit.ly/42oxkWH

Email us at nischr@nanoimagingservices.com to get started imaging your lipid nanoparticles!

It’s FAQ Friday! A well characterized sample can make all the difference for cryo-EM structure determination.

What characterization techniques do we recommend? Check in with Dr. Sarah Strassler Sulley to find out!

What else do you want to know about cryo-EM? Let us know.

Rediscover the fundamentals of cryo-EM with NIS CSO, Giovanna Scapin! Join us for three engaging sessions covering Sample Preparation & Imaging, Data Process... Cryo-EM: Back to Basics - Chapter 1

The third and final chapter of our webinar series “Cryo-EM: Back to Basics” is on demand. Hear from Giovanna about challenges in #cryoEM, how to overcome them.

Catch all three chapters:

Chapter 1: youtu.be/e8GyDe4_BAQ
Chapter 2: youtu.be/2dBnPVkaoFs
Chapter 3: youtu.be/kUGNSTGc8II

FAQ Friday! Have you ever wondered about the difference between Krios & Glacios microscopes? Find out now!

What #cryoEM questions do you have?

Blebs on LNPs are mysterious & strange. Where do they come from? What impact do they have?

Scientist Brent Wood explores blebs & other morphological features of LNPs that can only be visualized with cryo-TEM.

Check out the images & literature review: www.nanoimagingservices.com/about/blog/t...

Seeing unexpected results in your gene & drug delivery vehicles? Cryo-TEM imaging & analysis can help.

Automated, quantitative payload encapsulation analysis can accelerate your therapeutic pipeline and help inform efficacy and safety.

www.nanoimagingservices.com/nanoparticle...

Welcome! You are invited to join a webinar: Cryo-EM: Back to Basics. After registering, you will receive a confirmation email about joining the webinar. Rediscover the fundamentals of cryo-EM with NIS CSO, Giovanna Scapin! Join us for three engaging sessions covering Sample Preparation & Imaging, Data Processing & Interpretation, and Overcoming Limita...

Don't miss the last session of the webinar series "Cryo-EM: Back to Basics" to hear CSO Giovanna Scapin's perspective on overcoming obstacles in cryo-EM structure determination.

Chapter 3: Overcoming Limitations | Tuesday, March 25, 11am PST, 2pm EST

Register: nimgs.zoom.us/webinar/regi...

Cryo Electron Tomography can reveal the 3D structures of heterogeneous nanoparticles, such as liposomes, LNPs, exosomes, extracellular vesicles.

3D volumes can provide a complete picture of morphology, surface decorations, & internal composition.

Learn more: bit.ly/cryo-et

Accelerate your discovery pipeline with a streamlined gene-to-structure workflow.

Customized services include protein production (mammalian, bacterial, insect), antibody production & sryo-EM structure.

Explore our new offerings: www.nanoimagingservices.com/structural-b...

Is your protein failing to crystallize?

Cryo-EM can overcome bottlenecks and sample limitations associated with XRC.

Compare cryo-EM & crystallography side-by-side: www.linkedin.com/smart-links/...