NanoImaging Services

Need support for your protein degrader projects?

Join our webinar for insights into our gene-to-structure workflow for producing high-quality, structure-grade CRBN-DDB1 ready for structure determination.

Register: nimgs.zoom.us/webinar/regi...

Welcome! You are invited to join a webinar: Soluble Proteins in Focus: Preparing for Cryo-EM Success. After registering, you will receive a confirmation email about joining the webinar. Are you using cryo-EM to look at small soluble proteins? Join Dr. Claudio Catalano, a Senior Scientist at NanoImaging Services, to get expert advice on how to set your project up for success. He will...

🧪 Just two days away! Join us for a gene-to-structure case study, from protein production to a 3.1 Å structure for CYP3A4, a 57 kDa cytochrome P450 monooxygenase and ask your questions live.

BONUS: Sign up for the webinar to get early access to the whitepaper! nimgs.zoom.us/webinar/regi...

🧪 Conflicting results from DLS? #CryoTEM imaging can provide quantitative and qualitative data for smaller particles, like iron nanoparticle formulations, all in one study. Reach out to nischr@nanoimagingservices.com to learn how cryo-TEM imaging can help you meet milestones faster.

Welcome! You are invited to join a webinar: Soluble Proteins in Focus: Preparing for Cryo-EM Success. After registering, you will receive a confirmation email about joining the webinar. Are you using cryo-EM to look at small soluble proteins? Join Dr. Claudio Catalano, a Senior Scientist at NanoImaging Services, to get expert advice on how to set your project up for success. He will...

🧪 Running into roadblocks with your proteins? Join us for a guide to setting your structure determination project up for success and case study of CYP3A4, a 57 kDa cytochrome P450 monooxygenase solved to 3.1 Å.

P.S. Get early access to the case study by registering!

🚀 Fast track your #HPV therapeutics with #cryoTEM imaging. From initial characterization to 3D structures, we support you throughout the entire pipeline, including regulatory submissions.

🧪 Want the proof? See our published work on Gardasil®: www.nanoimagingservices.com/resources/ho...

Welcome! You are invited to join a webinar: Soluble Proteins in Focus: Preparing for Cryo-EM Success. After registering, you will receive a confirmation email about joining the webinar. Are you using cryo-EM to look at small soluble proteins? Join Dr. Claudio Catalano, a Senior Scientist at NanoImaging Services, to get expert advice on how to set your project up for success. He wil...

🧪 Skip the trial and error for structure determination of soluble proteins. Join the #webinar 10/8 for a gene-to-structure case study of CYP3A4, a 57 kDa cytochrome P450 monooxygenase, solved to 3.1 Å by #cryoEM.

nimgs.zoom.us/webinar/regi...

🧪 Are you using cryo-EM to look at small soluble proteins? Walk through each stage from protein production to structure determination, with practical insights and lessons from a recent case study on CYP3A4 with live Q&A.

Register: nimgs.zoom.us/webinar/regi...

When it comes to #lentivirus characterization, seeing is believing. Traditional analytical methods tell you what's there, but #cryoTEM shows you exactly how it's organized.

Learn more: www.nanoimagingservices.com/nanoparticle...

How do you choose a nanoparticle characterization method? While there are many techniques available, cryo-TEM stands out by revealing information other methods miss.

Dive into the comparison: www.nanoimagingservices.com/about/blog/v...

Ever wondered how buffers impact #cryoEM structures?

🧪 DMSO and cryoprotectants can be tolerated at low concentrations. If you're curious if your buffer will be compatible, schedule a call with our experts: www.nanoimagingservices.com/contact

Are you looking for comprehensive, reliable particle sizing analysis? From LNPs to iron nanoparticles, cryo-TEM semi-automated particle contouring and sizing provides precise particle size distribution measurement for a range of samples.

Learn more at www.nanoimagingservices.com/nanoparticle...

🧪 Ever wondered what the difference is between #cryoEM and #negativestain #TEM is? Find out in today's FAQ Friday!

Join Dr. Mandy Janssen, Scientific Director of Characterization at NIS, to:- Discover how cryo-TEM enables high-resolution visualization of individual LNPs i... Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Do you know how #LNPs show up in #cryoTEM versus negative stain TEM?

Want to learn more about the advantages of cryo-TEM for LNPs and other #liposomal samples? Tune in for the full webinar from Dr. Maria (Mandy) Janssen:

During a recent webinar, we were asked, “How does automated cryo-TEM particle picking for AAV full/empty capsids compare to other orthogonal methods?”

Watch the webinar in full for a great explanation of cryo-TEM imaging & analysis of AAV, and more of your great questions: youtu.be/w7kRfNZX_SI

Poor contrast TEM images got you feeling grey? No problem!

Our latest tutorial will help you quickly & easily enhance the contrast and add scale bars to your #cryoTEM or negative stain TEM images so they’re ready for publication:
www.nanoimagingservices.com/about/blog/e...

Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Did you miss our webinar last week? You can now catch this amazing talk from Dr. Mandy Janssen about #cryoTEM #LNP characterization, NIS’s proprietary AI tools for image analysis, and a case study showing unique insights only cryo-TEM can provide.

Catch it here:

Unlocking the Secrets of RNA: Protein-Free Structure Determination w/ Cryo-EM Unlock the secrets of RNA molecules with cryo-EM. High resolution data collection & structure determination with cryo-EM for structure based drug discovery at NIS.

Are you struggling to solve the structure of your #RNA molecule? Cryo-EM study RNA in its native, unbound state, without the influence of associated proteins?

Learn more about the potential of #cryoEM single particle analysis for protein-free RNA: www.nanoimagingservices.com/about/blog/u...

Unexpected results in your #LNP formulations? Join our webinar + Q&A to learn how #cryoTEM imaging can help provide answers.

We will reveal how cryo-TEM can provide reliable, reproducible data (size, morphology, lamellarity, blebs) in one dataset.

Sign up: nimgs.zoom.us/webinar/regi...

Have you signed up yet? In just 1 week, Dr. Mandy Janssen will be giving a webinar + Q&A diving into the applications of #cryoTEM for #LNP development!

Don't miss out on this deep dive: nimgs.zoom.us/webinar/regi...

Can't make it live? Sign up to get a recording, or send in your questions!

FAQ Friday! Dr. Sarah Strassler Sulley touches on the differences between cryo-EM and HDX for epitop emapping.

Want more? Check out our blog with an in-depth technique comparison: www.nanoimagingservices.com/about/blog/e...

Looking for ways to enhance your #LNP analysis tools?

Dr. Mandy Janssen will present how #cryoTEM imaging & automated analysis can reveal multiple CQAs all in one dataset.

Questions? Stick around after the webinar for a Q&A with Mandy.

Sign up: nimgs.zoom.us/webinar/regi...

How big are cryo-EM grids exactly? Find out!

It's tomorrow! Join us to learn about automated cryo-TEM analysis of AAV full/empty capsid ratios.

Can't make it? Sign up anyway to receive a recording.

Don't miss this webinar + Q&A session: nimgs.zoom.us/webinar/regi...

Webinar! Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools

Enable high-resolution visualization of LNPs in near-native state, analyze multiple CQAs in 1 dataset, & use automated image analysis tools for quantitative measurements.

Register: nimgs.zoom.us/webinar/regi...

One week out! Join us for a webinar, "Automated Cryo-TEM Analysis of AAV Empty/Full Capsid Ratios".

Whether you're troubleshooting or aiming to streamline AAV manufacturing process, we'll demonstrate how cryo-TEM can drive faster informed decisions.

Sign up: nimgs.zoom.us/webinar/regi...

Welcome! You are invited to join a webinar: Automated Cryo-TEM Analysis of AAV Empty/Full Capsid Ratios. After registering, you will receive a confirmation email about joining the webinar. Join Dr. Eric Bushong, Principal Scientist, for a 30 minute webinar followed by live Q&A. - Explore the advantages of cryo-TEM for characterizing AAV formulations - See how empty/full capsids are qu...

Don't miss this webinar! "Automated Cryo-TEM Analysis of AAV Empty/Full Capsid Ratios" on 5/15, 11am PST, 2pm EST.

Whether you're troubleshooting or aiming to streamline AAV manufacturing process, we'll demonstrate how cryo-TEM can drive faster informed decisions.

nimgs.zoom.us/webinar/regi...

Welcome! You are invited to join a webinar: Quantitative Empty/Full Analysis of AAV Capsids Using Cryo-TEM. After registering, you will receive a confirmation email about joining the webinar. Join Dr. Eric Bushong, Principal Scientist, for a 30 minute webinar followed by live Q&A. - The advantages of the cryo-TEM approach for assessing AAV formulations - How AAV empty/full capsid status ...

Live webinar! Learn about automated AAV empty/full capsid ratio analysis with cryo-TEM on Thursday May 15, 11am PST, 2pm EST.

Learn the advantages of cryoTEM for assessing AAV formulations & how AAV empty/full capsid status is determined.

Sign up: nimgs.zoom.us/webinar/regi...

What are sample size requirements for Single Particle Analysis cryo-EM? Join Dr. Sarah Strassler Sulley to find out!

Questions about cryo-EM? Let us know!

Did you know cryo-TEM is the only technique that can visualize blebbing on LNPs?

Check out our latest blog for detailed examples of blebs & bilayers, and a literature review: bit.ly/42oxkWH

Email us at nischr@nanoimagingservices.com to get started imaging your lipid nanoparticles!

It’s FAQ Friday! A well characterized sample can make all the difference for cryo-EM structure determination.

What characterization techniques do we recommend? Check in with Dr. Sarah Strassler Sulley to find out!

What else do you want to know about cryo-EM? Let us know.