Samantha Lapehn, PhD

An assessment of organophosphate ester mixtures and the placental transcriptome Prenatal exposure to organophosphate ester (OPE) chemicals, commonly used as flame retardants and plasticizers, has been associated with adverse birth…

New Paper evaluating prenatal organophosphate ester (OPE) exposure on the placental transcriptome in the CANDLE study. We investigated OPE metabolites individually and in mixture on placental genes & co-expressed gene modules.
www.sciencedirect.com/science/arti...
#placenta #environment #pregnancy

I’ll be presenting our work from the Paquette Lab on EDCs and microRNA expression in the CANDLE study this morning at SOT (Poster E273, 9:15-11:45am). #SOT2025

Check out Mariana's first Paquette Lab paper on Vit D and the placental transcriptome

Paquette Lab - CTPMA This web based shiny application was designed to provide a user friendly interface for searching and visualizing data regarding global transcriptomic differences in placental tissue and in-vitro model...

We found that experimental model selection should be dependent on genes/pathways of interest and developed the "Comparative Transcriptomic Placental Model Atlas" to assist in evaluating gene expression differences in bulk placental tissue and experimental models. www.paquettelab.org/placental-co...

A Transcriptomic comparison of in vitro models of the human placenta Selecting an in vitro culture model of the human placenta is challenging due to representation of different trophoblast cell types with distinct biolo…

New Paper- We compared the transcriptome of bulk placental tissue from two ECHO cohorts to publicly available data from common in vitro placental models to see which experimental models most closely approximated the bulk tissue transcriptome.

www.sciencedirect.com/science/arti...