Paul Francois

Il n’y a plus qu’à espérer qu’on aille loin en Coupe du Monde sinon on va en reprendre une louche …

En plus ce n’est pas la première fois qu’il gagne non ?

Researchers say the ancient breakup of tectonic plates creates churning waves in Earth’s mantle that tumble in slow motion under the continents for tens of millions of years, sculpting topography deep within continental interiors.

Learn more: https://scim.ag/4s8GTEs #ScienceMagArchives

There were recent discussions on the sharp decline of home cooking in the US (vs the fast food/take out culture), it would be interesting to see if diversity in grocery store relates to this (the fewer people cook at home, the fewer diversity because some things are not profitable ?)

I guess that, contrary to Asimov's, our current version of AI needs huge amounts of data from the Internet, which then comes with all the political craziness due to all online activities. So maybe it is not such a coincidence that AI soars during a crazy political moment.

This moment when you realize that Asimov's Laws of Robotics were orders of magnitude more clever than anything happening in reality. You wonder what would have happened if AI had rather expanded under any other past presidency.

Aïe aïe aïe …

J’espère que il y a une place spéciale en enfer pour les gens qui mettent les crottes de leur chien dans la poubelle à compost de leurs voisins

France lit the Eiffel Tower in blue and yellow on the fourth anniversary of Russia’s full scale invasion of Ukraine, signaling solidarity and support for the Ukrainian people. #France

AlphaGenome: On the Promise and Limits of AI in Science PHILIP BALL | According to the old story, we once thought that all this other DNA was just “junk,” a term coined in this context in the 1970s. It was accumulated over the course of evolution, for exam...

“It would be foolish to suppose that black box AI can save us from the daunting task of understanding how genomes work. But who would want to forego that anyway, given the intellectual richness & beauty that, for all its messiness, modern molecular biology is revealing?” @philipcball.bsky.social 🙌🎯🧪

Les États-Unis en mal de contre-pouvoirs Les États-Unis ne sont pas prêts à faire front contre l’extrême droite, prévient le politologue Mark Copelovitch.

BTW great interview over the week-end in @ledevoir.com oir.com @mcopelov.bsky.social www.ledevoir.com/monde/etats-...

Channeling my inner @mcopelov.bsky.social : "other countries have domestic agenda" 🙂

I am teaching a bioinformatics class where the final grade used to be 60% coding homework. Obviously I have to change this otherwise it is simply meaningless.

The sad thing is that everyone has been trying to slowly move away from or complement oral and written exams, because they were generating a lot of anxiety (among other things). Now we have no other choice that to move fully back to it. What is the point of giving any graded homework ?

I was supposed to fly to Boston tomorrow…. Third year in a row that I have to cancel a talk in the US because of a snowstorm. At least this time I will not have to wait for hours in Trudeau !

Suprematism, by Nikolai Suetin, 1920-21, 📸 by @tiltoncreative

J'ai l'impression de regarder un match de foot de l'équipe de France : domination outrageuse mais incapable de marquer et on tire de l'arrière.

I know nothing about hockey, but I feel deep in my heart that Suzuki will save us.

"I seem unreliable, but I'm actually very reliable. You just have to trust the process." Alysa Liu, U.S. Olympic figure skater

When I’m two weeks behind on my grading.

Milan-Cortina: Trump prepares for his visit to the Olympics. - L'Unione Sarda English The president could arrive in Italy on Sunday, February 22, for the possible final of the US men's national hockey team.

Si Trump fait ça, qu’on me lâche à tout jamais avec le ArRêTeZ dE MêLeR sPoRt Et PoLiTiQuE.

www.unionesarda.it/en/world/mil...

Just realized that I am teaching during the Canada-USA hockey final.

citation of Rabelais' 'substantifique moelle'

On a side not, I am very proud of Grégoire who included a Rabelais' citation to talk about our work, he and I are still a bit French after all.

On the theory side, we present what I now consider a definitive explanation of the Adaptive Kinetic Proofreading framework. You will find concise mathematical derivations, including discussions on the separation/contributions of the adaptive and kinetic proofreading components ! 4/4

Rather than framing T cell responses in terms of classification or discrimination (e.g., self vs. non-self), we deliberately use discernment. This better captures the fact that T cell activation is a continuous, dynamical process rather than a binary decision. 3/4

It brings together nearly 20 years of research (and many enjoyable discussions!) from the golden days of systems biology to robotic experiments coupled with machine learning, culminating in the design of antagonism-based cancer immunotherapies. 2/4

Learning the Principles of T Cell Antigen Discernment T cells are central to the adaptive immune response, capable of detecting pathogenic antigens while ignoring healthy tissues with remarkable specificity and sensitivity. Quantitatively understanding h...

Happy to share our latest review article, “Learning the Principles of T Cell Antigen Discernment.” www.annualreviews.org/content/jour...
with @fxpbourassa.bsky.social , Sooraj Achar and Grégoire Altan-Bonnet ! 1/4

“Or [France] was right, but got on everyone’s nerves.” 🤣🤣

Just tested it, it is crazy (and it is directly translated in French for me !)

Ah oui merci, effectivement !

Pourquoi la France est-elle si bonne en biathlon ? Lors des JO d'Albertville, je croyais que c'était à cause des bataillons de l'armée type Chasseurs Alpins qui permettaient de s'entraîner, etc... mais plus l'air d'être le cas maintenant.