Therapeutic Advances in Infectious Disease

Peptide-based vaccines are redefining precision immunology, offering safety, specificity,scalable manufacturing. This review explores how bioinformatics-driven epitope design, nanoparticles,& next-gen adjuvants are fighting viral threats 🚀🦠
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Ticks strike twice 🐜🐜 Fatal Babesia microti/Borrelia burgdorferi coinfection presenting as acute liver failure and shock. Read full case @
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

🦠 Rare but severe: necrotizing gingival & sinus infection due to Trichoderma longibrachiatum in an allo-HSCT recipient. Cure achieved with aggressive surgery 🔪 + combination antifungals 💊, including consolidation with rezafungin.
journals.sagepub.com/doi/full/10....

Towards personalised empirical antibiotic therapy in febrile neutropenia: a theoretical model based on machine learning and prior colonisation with multidrug-resistant gram-negative bacilli – a retros... Background: Empirical antibiotic therapy (EAT) in febrile neutropenia (FN) remains challenging due to multidrug-resistant (MDR) Gram-negative bacteria, often le...

Febrile neutropenia still drives heavy carbapenem use due to MDR Gram-negatives. In a cohort of 553 FN episodes, an ML risk model + prior colonisation data could cut meropenem use by ~30% and IEAT from 23% to 9%, supporting personalised EAT.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Chronic pulmonary aspergillosis can complicate pulmonary echinococcosis via residual lung cavities. In this review (41 studies, 72 CPA cases), diagnosis relied on radiology/histology, combined surgical–medical therapy led to uniformly favorable outcomes
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

⚠️ Rising MDR in cUTIs demands new options. Plazomicin shows strong in-vitro activity, synergy with key agents, and favorable outcomes in trials—yet real-world evidence from LMICs is urgently needed 📉📊.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Imidazolopiperazines (KAF156/ganaplacide) show potent activity across blood, liver, and gametocyte stages of Plasmodium 🦟💊—a promising path forward as antimalarial resistance rises.
journals.sagepub.com/doi/full/10....

Micrococcus luteus-induced prosthetic valve infective endocarditis in an immunocompetent patient: a case report from India - Ritvik Sajan, Sreekrishnan Trikkur Parasuraman, Akhil Arun, 2025 Micrococcus luteus (M. luteus) is a Gram-positive microorganism that typically dwells in environments such as soil, water, and human skin, hence, entitling it a...

🧬 Unusual infection: M. luteus, normally a skin commensal, triggered prosthetic valve endocarditis in an immunocompetent woman. 8 weeks of IV vancomycin led to full recovery.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

📊 New study from Teso, Uganda: Among 1009 TB patients, overall treatment success was 91.9%. Females had higher success, while age >49 and HIV infection lowered success. Early screening, preventive therapy, and peer support are key to improving outcomes.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Antipseudomonal beta lactams yielded outcomes similar to cefazolin/oxacillin in this study of of MSSA bacteremia.However there were more complicated infections in the SOC arm.These data may inform antibiotic choices when broad coverage is needed.
journals.sagepub.com/doi/full/10....

Proceedings from Group B Strep in Pregnancy & Babies Conference, Wednesday, May 14th 2025, virtual meeting, 2025

Check out highlights from the 2025 Group B Strep in Pregnancy & Babies Conference: new data spanning antimicrobial stewardship, epidemiology, diagnostics, prevention policies, virulence profiling, and next-gen sequencing for neonatal GBS.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

AI-driven models are showing clear promise in improving HIV/TB detection and management in Nigeria, where immunosuppression drives disproportionate TB risk. Strengthening technical capacity will be essential for translating this potential into practice.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Data from 89 patients suggest that follow-up FDG-PET/CT can guide decisions in focal infections but is most informative when bacteremia is gram-positive or clinical status deteriorates. Findings support targeted rather than routine use. 🔍🦠📊 journals.sagepub.com/doi/full/10....

Recurrent UTIs remain a major burden, and new guidance is steering care toward non-antibiotic prevention—behavioural measures, topical oestrogen, methenamine hippurate, and intravesical HA/CS 💡💊💧
Read this review for more 📘✨
journals.sagepub.com/doi/full/10....

Antibiotics disrupt gut/airway microbiomes across ages 🦠, amplifying both targeted and background resistance genes 🧬. Recovery remains especially poor in children 👶
journals.sagepub.com/doi/full/10....

Impact of a multistep urinary tract infection-focused disease state stewardship initiative on the treatment of asymptomatic urinary presentations: a retrospective cohort study - Christian Tyler Pitcoc... Background: Asymptomatic bacteriuria (ASB) is often overtreated, risking patient harm through unnecessary antimicrobial use and fostering antimicrobial resistan...

A multistep UTI-focused stewardship initiative reduced unnecessary treatment of asymptomatic presentations by 12% & improved adherence to UTI management guidelines.
journals.sagepub.com/doi/full/10....

Novel entomo-virological tools, such as honey-baited traps preserving mosquito-expectorated RNA, are reshaping arbovirus monitoring. Integrating these with genomic surveillance can bridge field ecology and molecular epidemiology. 🔬🦟https://journals.sagepub.com/doi/full/10.1177/20499361251391261

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

P. aeruginosa is the archetype of adaptive resistance—porins close, pumps activate, enzymes evolve. New β-lactam/β-lactamase inhibitor combos and cefiderocol offer treatment options.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

📈 Retrospective time-series study (2014–2019, Mysuru, India):
Rising temperature, humidity, and monsoon rainfall were linked to increased Salmonella bacteraemia.
Findings suggest climate–infection interplay with implications for AMR trends.
journals.sagepub.com/doi/full/10....

Comparative effectiveness of cefazolin versus antistaphylococcal penicillins in methicillin-susceptible Staphylococcus aureus infective endocarditis: a systematic review of observational studies - Lau... Background: Methicillin-susceptible Staphylococcus aureus (MSSA) is a leading cause of infective endocarditis (IE), associated with high morbidity and mortality...

Meta-analysis (7 studies, n=1685): Cefazolin vs. ASPs for MSSA endocarditis — similar efficacy, lower 30-day mortality (OR 0.49, 95% CI 0.29–0.83), and fewer adverse events. Supports cefazolin as a viable alternative
journals.sagepub.com/doi/full/10....

Diagnostic accuracy of the novel and biosafe molecular assay Orange G3 TBC compared to GeneXpert for tuberculosis diagnosis in resource-limited settings - Juan Carlos Garberi, Gabriel Estryk, Richard ... Background: Tuberculosis (TB) remains a global public health priority, with 10.5 million new cases and 1.5 million deaths reported in 2023. Current diagnostic m...

🚨study from Bolivia: A novel PCR platform—Orange G3 TBC—shows comparable accuracy to GeneXpert Ultra for TB diagnosis (sensitivity = 90%, specificity = 97%). Its biosafe, low-resource–friendly design could expand TB testing access in endemic settings.
journals.sagepub.com/doi/full/10....

Excited to see everyone at #IDWeek2025! Catch the @TAInfDis team sharing insights across these great sessions.

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

A systematic review (2003–2023) shows live attenuated (LAIV) and inactivated (IIV) influenza vaccines protect children/adolescents equally well (~50% VE). Post-2017 LAIV strain updates restored H1N1 protection and improved efficacy vs influenza B.
journals.sagepub.com/doi/full/10....

Attitudes of HIV healthcare Provider Attitudes Towards PWH who use Drugs and acceptance of harm reduction strategies: a cross-sectional study - Rabab F. M. Ahmed, Robert W. S. Coulter, M. Reuel Friedm... Background: Negative attitudes toward people who use drugs (PWUD) can hinder their engagement in healthcare and contribute to poor clinical outcomes. While harm...

In a survey of 128 HIV care workers, negative attitudes toward people who use drugs were strongly linked to lower acceptance of harm reduction practices. Acceptance varied by site, race, and experience—pointing to structural and training gaps.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Dolutegravir/lamivudine improved quality of life, treatment acceptability, and symptom burden in PLWH over 6 months (French multicenter study, n=260). Gains appeared by month 1 and persisted. Monitoring discontinuations—especially among women—remains key.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Systematic review/meta-analysis (2013–2024, n=23,319): In febrile neutropenia after chemotherapy, bloodstream infections were 59% Gram-negative, 39.7% Gram-positive, and 2.5% fungal.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

The Clade IIb #mpox 🌍 outbreak exposed major gaps in evidence for antivirals 💊, vaccine equity 💉, and surveillance. This review maps the path toward targeted, evidence-based treatments and prevention✨
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

ED study in Japan: Relaxation of COVID-19 IPC practices led to a surge in virus-related exacerbations of COPD (7.7%→52.5%) & asthma (39.7%→66.7%). Reinforcing viral prevention is key in chronic airway disease care.
journals.sagepub.com/doi/full/10....

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

📊 HIV from injection drug use is climbing (2016–2022).
PrEP uptake in PWID remains critically low.
Call to action: integrate ID + addiction care, expand low-barrier services, implement LA-PrEP, and fight stigma through policy + education.
journals.sagepub.com/doi/full/10....

A descriptive survey evaluating the implementation and outcomes of a training session highlighting concepts in antimicrobial management and harm reduction for hospital-based clinicians treating person... Background: People who use drugs (PWUD) are at increased risk for severe infections and face many barriers when completing conventional, typically parenteral an...

Hospital clinician training transformed care for PWUD w/ severe infections. Post-training: 95% applied harm reduction (vs 55%), 69% discussed safer use (vs 38%).
journals.sagepub.com/doi/full/10....