Matt Yousefzadeh

The "biggest baddest" bias in aging research: A spirited GSA debate.

For those of you attending #GSA2025 in Boston, consider this panel of #NIH awardees, Drs. Alden Gross, @mariaglymour.bsky.social , @sfackley.bsky.social , and @bryandjames.bsky.social. Please remember to tag #geronsky and @geronsociety.bsky.social in your posts.

📢📢Apply now for GRS/GRC on DNA Damage Mutation & Cancer in sunny Ventura CA.

Sorry man, but fingers crossed for you!

First, pos-neg gating. Ideal controls are your actual antibodies on the actual cells. However different antibodies bind different cells (see: CD4 vs XCR1 below), meaning they have different backgrounds to control. AutoSpectral matches the FSC-SSC of each pos to a suitable neg: with results!

Indoor Rewilding of Laboratory Mice Recalibrates Pulmonary Mucosal Immunity and Mechanics @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

Looks like Hevolution is not funding anything (GRO, postdoc, etc.) from the 2024 cycle?

Pro tip: make sure your myNCBI profile is linked to your eRA account and that you link awards to papers directly in there.

Evidence for an energetic trade-off model linking inflammaging and immunosenescence in the US Health and Retirement Study and UK Biobank Later life is characterized by the development of chronic inflammation, termed inflammaging, alongside changes in immune cell profiles, or immunosenescence. While these features contribute to health r...

www.biorxiv.org/content/10.1...

THE FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle A growing number of therapies are being developed to target the cell cycle machinery for the treatment of cancer and other human diseases. Consequently, a greater understanding of the factors regulati...

www.biorxiv.org/content/10.1...

Right there with you.

It was a huge e-audience! Great talk as always and really cool science.

@dremilygoldberg.bsky.social Great talk today!!!

Didn’t think of that!

I guess they will make the postdocs ride out J1's for as they can?

Current mood while writing up a specific aims page.

Introducing the Dish Soap Protocol: A Unified Approach for Multi‐Modal Intracellular Staining Recent advances in dyes and cytometers have seen an exponential increase in the ability to perform multidimensional flow cytometry. As we increase our capacity to extract information from cells, the ....

Very cool.

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

We are so glad to share that the Nathan Shock Centers Coordinating Center (NSC3) will continue its mission after receiving a five-year grant renewal! The American Federation for Aging Research (AFAR) will lead NSC3 activities with the $5.7 million NIH award. Read more here: bit.ly/45yQz2B

Program staff reductions at the NIH ICs Propublica has published a report on the loss of staff positions at various government agencies since January of 2025. This includes a list of percent losses at each NIH IC due to firings, layoffs,…

Program staff reductions at the NIH ICs drugmonkey.wordpress.com/2025/08/22/p...

The application for the The Department of Biochemistry & Physiology Assistant Professor/Faculty Position is open now! Apply now if you're interested in investigating inflammation, cellular senescence, immunology, lipid metabolism, and/or neurodegeneration! 🧠
🔗 jobs.sciencecareers.org/job/674553

New stuff!

@bbparis1984.bsky.social

Sex differences in tissue-specific immunity and immunology Biological sex exerts a substantial influence on the immune system and immune-related diseases. Males are more susceptible to the acute effects of viral disease and certain cancers, whereas females ex...

www.science.org/doi/10.1126/...

I feel like institutions trim down their startup packages too if this became a thing.

Thanks!

Aging reshapes the adaptive immune system from healer to saboteur - Nature Aging Delgado-Pulido, Yousefzadeh and Mittelbrunn explore the molecular mechanisms by which adaptive immunity regulates the processes of aging, discussing age-related declines in protective functions and ag...

Much thanks to Sandra Delgado-Pulido and Maria Mittelbrunn for letting me be a part of this perspective describing how an aged adaptive immune system can go off the rails to disrupt tissue homeostasis and drive aging.
www.nature.com/articles/s43...

Great collection of articles on senescence & aging derived from the recent CSHL 2025 Symposium

Travel awards are available for the NIA Geroscience Education and Training (GET) Network Workshop, where attendees can learn how to educate aspiring translational geroscientists, and introduce graduate students, medical students, or geriatrics fellows to geroscience. Learn more here: bit.ly/4ozUALB

Exclusive: Harvard University lays off fly database team The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

Very sad to see.
www.thetransmitter.org/community/ha...

Very cool. Thanks for the tip and the history lesson!