ACIR

Johansen, Wolff, Scapolo, et al. used a known crystal structure, RFdiffusion, and other generative models to rapidly de novo design high-affinity minibinders (miBds) targeting the [...] bit.ly/3J1yoK8 ‪@mfernandezquintero.bsky.social‬  ‪@scripps.edu‬  ‪@tpjenkins.bsky.social‬

⭕ How to leverage a tumor - a review on the emerging excitement about neoadjuvant immunotherapy doi.org/10.1038/s430...

🐥 The new kids on the block Rock! - Newly emergent genes are tied to tumorigenesis and may be good neoantigens doi.org/10.1016/j.xg...

Ahn et al. showed in vitro (using human PBMCs) and in mice that IL-10 suppressed IL-2 induction of CRS-associated cytokines by suppressing TNFα production while potentiating IL-2-mediated antitumor activities. bit.ly/3UPCMhO

Murer et al. engineered ANV600 – a novel bispecific antibody–cytokine fusion protein that binds to a non-blocking PD-1 epitope and targets IL-2 to PD-1-expressing cells, without interfering with concomitant anti-PD-1 therapy. bit.ly/46EZUH7

Huang, Theelen, and Belcaid et al. report the immunomodulatory effects of stereotactic body radiation therapy (SBRT) followed by pembrolizumab in patients with metastatic NSCLC based on a phase 2 trial. bit.ly/4omCD32  ‪@johnshopkinsmmi.bsky.social‬  ‪@nkinl.bsky.social‬

Gong and Luo et al. developed the Cancer Immunology Data Engine (CIDE) using 90 omics datasets with 8,575 profiles from 5,957 patients with 17 solid tumor types. bit.ly/4mtCGID

A novel pipeline could be used to design binder proteins that mimic the TCR in targeting of peptides bound to MHCI molecules 👉 bit.ly/453lmo2

Zabala-Peñafiel, Gonzalez-Lombana et al. showed that mice vaccinated s.c. with LNPs containing mRNA encoding leishmanial PEPCK antigen generated specific dLN and splenic Th1 and T follicular helper cells [...] bit.ly/3GMQ4sk

We cover 3-5 cancer research conferences a year distilling standout talks and fresh insights.
Thanks to our readers for caring. And to the speakers: your work shines even brighter in our newsletter 💙
#CancerScience #ConferenceCoverage #CancerResearch #ScienceCommunication bit.ly/3SY9M6V

Testing various combinations, Fan et al. found that the administration of bispecific killer cell-engager (BiKE)-secreting CAR T cells alongside weekly injections of NK cells was optimal for achieving long-term control in murine hematologic tumor models. bit.ly/4fiafLm

👉 More is not always better - low, but not high, dose irradiation enhances responses to ICB doi.org/10.1136/jitc...

💨 Just breathe: Respiration in mitochondria is linked to T cell fate doi.org/10.1038/s415...

Qdaisat, Wummer, and Stover et al. demonstrated that early type-I interferon responses restored a defective damage response in poorly immunogenic tumors to enable epitope spreading and sensitivity to ICB. bit.ly/4ojxAk6  ‪@ufmbi.bsky.social‬  @ufhealthcancer.bsky.social‬

Lin, Fukuoka, and Koyama et al. focused on how gut microbiota influence the clinical efficacy of ICB. A newly identified bacterial strain named YB328 (genus hominenteromicrobium), was significantly elevated in feces of patients who [...] bit.ly/4mhzj7t  

Niessl et al. found that blood-derived memory CD8+ T cells exhibited greater basal cytotoxic molecule expression than T cells from matched tissue, while resident memory cells exhibited the weakest cytotoxicity profile. bit.ly/4l0JAnp  ‪@ki.se‬

Quijano, Martinez-Saucedo, and Ianniello et al. showed that the mAb TMAB3 noncovalently bound to 3p-hpRNA to form stable antibody/RNA complexes that delivered 3p-hpRNA specifically to premalignant and malignant cells. bit.ly/4mdmM4W   ‪@yalecancer.bsky.social‬

Novel ICB-targeting nanobody conjugates block checkpoints and carry payloads to improve efficacy. Read our digest here 👉 bit.ly/40DUl88  

Focused on improving bacteria-mediated cancer immunotherapy responses in osteosarcoma (OS) with liver metastases, Liu, Liu, and Yang et al. engineered a novel Salmonella strain to express CCL2 and CCL9 (VNP-C-C). bit.ly/4m6Sh0v

Ray et al. discovered that Cd69 mRNA levels could be used to differentiate between potent and dysfunctional activation states among intratumoral CD69+CD8+ T cells. bit.ly/4kQGYsg   ‪@maxkrummel.bsky.social‬

Desbois et al. generated IGM-7354, an IgM comprising ten PD-L1 binding sites which blocked PD-L1/PD-1 binding and a single IL15/IL15Rα complex which activated IL15Rβγ+ human NK and CD8+ T cells and rescued TEX cells in vitro. bit.ly/4lLTn26  

Song et al used stop codon-separated tandem constructs encoding a control peptide via canonical ATG and SIINFEKL via noncanonical CTG to examine noncanonical translation. bit.ly/4m6RTz5   ‪@erasmusmc.bsky.social‬

Venzin and Beccaria et al. demonstrate that pre-activated CD4+ T cells actively license local hepatic APCs and restore antiviral CD8+ T cell function. bit.ly/4kRAbhS  ‪@valentinavenzin.bsky.social‬  @cristianbeccaria.bsky.social‬  ‪@iannaconelab.bsky.social‬

In a phase 1b trial, 82 patients with esophageal squamous cell carcinoma were treated with an anti-EGFR/HER3 bispecific antibody linked to a topoisomerase I inhibitor, at 2.0 or 2.5 mg/kg q3wks. bit.ly/3IXUT2o

Revach et al. recently showed that CD38 drives T cell exhaustion under chronic antigen stimulation and IFN signaling in the TME acir.org/weekly-dige...  ‪@massgenbrigham.bsky.social‬

Sek and Chen et al. demonstrated that overexpression of the adenosine receptor A1R in CAR T cells reduced cAMP levels, and enhanced baseline and antigen-induced cytokine production and effector differentiation. bit.ly/44PEHYr   @petermaccc.bsky.social‬

Humblin et al. showed that sustained ICOS signaling impaired CD8+ T cell survival and function during chronic antigen exposure. bit.ly/46bvdsX  @sinaiimmuno.bsky.social‬

To overcome the poor persistence and progressive loss of functionality of TCR-engineered T cells, in vivo, Nowicki et al. evaluated tandem treatment with autologous blood-derived T cells and hematopoietic stem cells [...] bit.ly/3GFCHtS  @parkerici.bsky.social‬

Kao et al. showed that at steady state, primary human T cells and T cells from FcγR-humanized mouse strains lacked FcγR expression, except for a small fraction of CD8+ T cells that expressed FcγRIIIa. bit.ly/4kCqsw5   ‪@rockefelleruniv.bsky.social‬

Phelps et al. investigated mechanisms underlying the positive benefits of exercise on ICI efficacy. In preclinical melanoma, adenocarcinoma, and lymphoma models, exercise promoted functional changes in the gut microbiome[...] bit.ly/4nUyC5S