3Brain AG

MEA‐seqX: High‐Resolution Profiling of Large‐Scale Electrophysiological and Transcriptional Network Dynamics How can we fully understand brain function and disease without uncovering the causal coordination between molecular and neural activity across space and time? MEA-seqX tackles this challenge by integ...

Check out the publication here: advanced.onlinelibrary.wiley.com/doi/10.1002/...

𝗠𝗘𝗔-𝘀𝗲𝗾𝗫: 𝗕𝗿𝗶𝗱𝗴𝗶𝗻𝗴 𝗠𝗼𝗹𝗲𝗰𝘂𝗹𝗲𝘀 𝗮𝗻𝗱 𝗠𝗶𝗻𝗱
What if you could link the brain’s complex dialogue between genes and electrical activity? With the recent publication in Advanced Science by Emery et al. from the Hayder Amin group, this link is now a reality with MEA-seqX.

Join via Google Meet: meet.google.com/tfu-yeea-oer

Curious about the neural mechanisms behind deep brain stimulation (DBS)?
Prof. Kragelund will be sharing insights in a webinar about her high-density microelectrode array recordings, revealing how DBS modulates network connectivity and activity patterns in dystonia and glioma-associated epilepsy.

CACNA1A loss-of-function affects neurogenesis in human iPSC-derived neural models - Cellular and Molecular Life Sciences CACNA1A encodes the pore-forming α1A subunit of the CaV2.1 calcium channel, whose altered function is associated with various neurological disorders, including forms of ataxia, epilepsy, and migraine....

Check it out here: link.springer.com/article/10.1...

𝗛𝗼𝘄 𝗮 𝘀𝗵𝗶𝗳𝘁 𝗶𝗻 𝗼𝗻𝗲 𝗴𝗲𝗻𝗲 𝗰𝗮𝗻 𝗿𝗲𝘄𝗿𝗶𝘁𝗲 𝘁𝗵𝗲 𝘀𝘁𝗼𝗿𝘆 𝗼𝗳 𝗯𝗿𝗮𝗶𝗻 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁

Thanks to 𝗠𝘂𝘀𝗮𝗻𝘁𝗲 et al. there are now two CRISPR iPSC neural lines carrying two CACNA1A mutations (F1491S and Y1854X). Want to know how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ helped them determine the functional changes they found?

Learn more about the Dean Lab’s work: www.dzne.de/en/research/...

Great data on brain organoids @ the 𝗘𝗠𝗕𝗢 | 𝗘𝗠𝗕𝗟 𝗢𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺! Hanna Dubrovska (DZNE Dean Lab) will present a poster using 𝟯𝗕𝗿𝗮𝗶𝗻 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 to highlight differences in neuronal activity and plasticity between forebrain and hippocampal-like organoids.

𝗙𝗹𝗮𝘀𝗵 𝗧𝗮𝗹𝗸 𝗦𝗲𝘀𝘀𝗶𝗼𝗻 𝟭: 𝗧𝗼𝗱𝗮𝘆, 𝟭𝟱:𝟮𝟬–𝟭𝟱:𝟱𝟬

Heading to 𝗘𝗠𝗕𝗢 | 𝗘𝗠𝗕𝗟 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 2025 (Oct 22–25, Heidelberg)?
See how CorePlate™ 3D electrodes anchor organoids, capture high-quality electrophysiology & support organoid health with microfluidic diffusion.
Meet Marco Acquila & Elisa Monz at our booth + don’t miss poster #219 by Bruno Sterlini.

Meet us at the Science & Tech Expo and learn how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ helps you capture more meaningful data from your biological models, whether you’re studying neurons, heart models, or brain slices. With precision, scalability, and real-time insight.

Check out the publication here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

How the Retina Talks to Itself: New Insights Into Visual Coding
Leveraging the high-resolution properties of CorePlate™, Szarka et al., revealed that 𝘁𝗿𝗮𝗻𝘀𝗶𝗲𝗻𝘁 𝗢𝗙𝗙 𝗮𝗹𝗽𝗵𝗮 𝗥𝗚𝗖𝘀 support inter cellular communication via gap junctions to help encode visual information.

Hands-on neuroscience in action! During our recent HD-MEA workshop at the 𝗙𝗖𝗕𝗚 - 𝗚𝗲𝗻𝗲𝘃𝗮, scientists explored the functional activity of brain slices and home-grown organoids using our six-well and single-well systems with 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 𝟯𝗗. Collaboration, insights, and curiosity all around!

Partnering with the 𝗦𝘂𝘇𝘂𝗸𝗶 𝗟𝗮𝗯 at the 𝗧𝗼𝗵𝗼𝗸𝘂 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲 𝗼𝗳 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆, we combined their iPSC-derived midbrain organoids with 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 𝟯𝗗 and observed dose-dependent increases in neuronal activity with L-Dopa. Working with brain organoids? Discover how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 𝟯𝗗 can help your research!

Final Call, Applications Close Today!
Don’t miss your chance to apply for the 𝟯𝗕𝗿𝗮𝗶𝗻 - 𝗠𝗮𝘀𝘀𝗶𝗺𝗼 𝗚𝗿𝗮𝘁𝘁𝗮𝗿𝗼𝗹𝗮 𝗔𝘄𝗮𝗿𝗱
• €𝟭𝟱,𝟬𝟬𝟬 to support your neuroscience research
• Free to apply
• Quick & easy application process
• Deadline: 𝟭𝟳:𝟬𝟬 𝗖𝗘𝗧 𝘁𝗼𝗱𝗮𝘆, 𝗢𝗰𝘁𝗼𝗯𝗲𝗿 𝟭, 𝟮𝟬𝟮𝟱
Apply now: www.3brain.com/the-3brain-m...