3Brain AG

High-density multielectrode array (MEA) recordings in a rodent glioma model High-grade gliomas are aggressive primary brain tumors that affect the surrounding brain tissue, which can lead to neurological deficits, epilepsy, co…

Check out the publication here: www.sciencedirect.com/science/arti...

𝗙𝗼𝗿𝗯𝗲𝗿𝗴𝗲𝗿, 𝗞𝗿𝗮𝗴𝗲𝗹𝘂𝗻𝗱 & 𝘁𝗵𝗲 𝗞𝗶𝗿𝘀𝗰𝗵𝘀𝘁𝗲𝗶𝗻 lab have developed a protocol which shows how to use CorePlate™ enabled 3D HD-MEAs (4,096 electrodes) to map how tumors disrupt brain networks. By tracking activity trajectories (CATs), they revealed lost functional connectivity in glioma models. #HDMEA #Cancer

WORD 2026 - This year, we presented a scientific poster on CorePlate™ recordings of hippocampal organoids and their responses to various neuroactive compounds. A huge thank‑you to everyone who visited our booth, discussed their work, and shared new ideas!
#WORD2026 #BrainOrganoids #HDMEA #Ephys

Meet us at the Science & Tech Expo on Feb 10 at the Alexandria Center, Stanford Research Park!

Discover how CorePlate™ HD‑MEAs enable deeper functional insights across neuronal & cardiac models. Plus free desserts, coffee & smoothies. Come say hi!

New research from 𝗜𝗮𝗻𝗻𝗲𝗹𝗹𝗼 & 𝗖𝗶𝗮𝗺𝗽𝗶 (𝗔𝗺𝗮𝘁𝗼 group) shows how cultured neurons can be used for Biological Reservoir Computing. By encoding images into electrical patterns via HD-MEAs, they’ve enabled biological networks to perform pattern recognition. Check out the paper here: arxiv.org/abs/2510.05637

Check out the paper here: www.cell.com/cell-stem-ce...

How do we better model cholinergic pathways? By building human brain assembloids. Using CorePlate™ 3D electrodes, the 𝗟𝗶𝘂 𝗟𝗮𝗯 recorded high-res data from hnbM-cortical projections, even transplanting them into mice to establish human-derived pathways. #3Brain #iPSC #HDMEA #Organoids #Assembloids

High resolution detection of stationary and evolving two-dimensional current source density within neuronal microcircuits | Journal of Neurophysiology | American Physiological Society The use of a high-density microelectrode array (>4,000 microelectrodes) allows the recording of evoked and ongoing field activity of the whole hippocampal formation and other tissues with high spatiot...

Check out the publication here: journals.physiology.org/doi/full/10....

𝗭𝗮𝗽𝗳𝗲 et al. used CorePlate™ to track the center of mass of current in the hippocampus. It’s not just data, it’s a way to see hidden synaptic interactions in high-res. As a bonus, the current source density (CSD) graphics are stunning!

#Electrophysiology #HDMEA #Hippocampus #NeuralCircuits

High resolution detection of stationary and evolving two-dimensional current source density within neuronal microcircuits | Journal of Neurophysiology | American Physiological Society The use of a high-density microelectrode array (>4,000 microelectrodes) allows the recording of evoked and ongoing field activity of the whole hippocampal formation and other tissues with high spatiot...

Check out the publication here: journals.physiology.org/doi/full/10....

Check out the preprint here: www.biorxiv.org/content/10.1...

𝗠𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗶𝗻 𝘁𝗵𝗲 𝗰𝗶𝗿𝗰𝘂𝗶𝘁!
𝗪𝘂 et al. show that adding human microglia to organoids and assembloids shapes circuit formation and activity, and that CorePlate™ HD-MEAs enabled them to reveal functional midbrain–striatal connectivity and hyperactivity in ASD-mutant assembloids.

Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency Demenego et al. show that inborn errors of immunity (IEI) directly impact neurodevelopment independently of immune dysfunction. In WHIM syndrome, CXCR4 hyperactivation disrupts cerebellar assembly and...

Check out the publication here: www.cell.com/neuron/fullt...

𝗪𝗵𝗲𝗻 𝗮𝗻 𝗜𝗺𝗺𝘂𝗻𝗲 𝗚𝗲𝗻𝗲 𝗥𝗲𝘄𝗿𝗶𝘁𝗲𝘀 𝗕𝗿𝗮𝗶𝗻 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁: 𝗗𝗲𝗺𝗲𝗻𝗲𝗴𝗼 et al. showed that hyperactive CXCR4 (linked to WHIM syndrome) disrupts cerebellar development and motor function, independent of infection. Using CorePlate™ HD-MEAs, researchers revealed circuit-level defects and a path to early intervention.

Tatton-Brown-Rahman-Syndrome-associated DNMT3A mutations de-repress cortical interneuron differentiation to disrupt neuronal network function Pathogenic mutations in DNMT3A cause Tatton-Brown-Rahman Syndrome (TBRS), a disorder characterized by somatic overgrowth of multiple tissues including the brain and intellectual disability (OGID). Her...

Check out the preprint here: www.biorxiv.org/content/10.1...

How DNMT3A mutations reshape neural circuits. New work shows TBRS-associated DNMT3A mutations disrupt human cortical interneuron development, driving GABAergic hyperactivity and abnormal network bursting, revealed using CorePlate™ enabled HD-MEAs.

#Neuroscience #3Brain #Electrophysiology #HDMEA

Reflecting on a year of innovation, connection, and discovery. To the researchers, applicants, and workshop attendees who made 2025 unforgettable: thank you. Your passion continues to be our greatest… 3Brain 2025 Year-End Wrap Up

Reflecting on 2025, we are reminded that behind every data point is a dedicated researcher. From our MGA applicants to the energy of our global workshops, your passion is our inspiration. Thank you for your contributions to neuroscience. Wishing you rest, joy, and a Merry Christmas. buff.ly/NqmRcK4

If you missed us at the conference or would like to learn more about how we can support your research, don’t hesitate to reach out at 3brain.com/contact.

A look back at the Assembloids & Complex Cell-Cell Interactions across Tissues & Organs meeting at CSHL. A fantastic conference exploring advances in assembloid research, with a workshop hosted by us to show how CorePlate™ enabled HD-MEA is helping functionally characterise assembloids.

At CSHL Assembloids? Our workshop is today, 𝗗𝗲𝗰 𝟵𝘁𝗵 𝗮𝘁 𝟭𝟮:𝟯𝟬𝗽𝗺! Join us for live experiments, software demos, and hands-on tools to assess organoid and assembloid activity. Stop by our booth to connect or register online for this interactive session: www.3brain.com/events/cshl-25

That’s a wrap on our “Recording Organoids with CorePlate™” workshop! From hands-on recordings in the Discovery Laboratory to BrainWave 6 analysis, the collaboration was inspiring. Huge thanks to all participants for the engagement—we are excited to see where your research goes next!

Unsupervised pipeline for the identification of cortical excitatory and inhibitory neurons in high-density multielectrode arrays with ground-truth validation A novel software tool and ground-truth optogenetic validation is provided to automatically detect putative excitatory and inhibitory cells in neuronal recordings performed with large-scale multielectr...

Check out the publication here: elifesciences.org/articles/106...

𝗗𝗲𝗰𝗼𝗱𝗶𝗻𝗴 𝘁𝗵𝗲 𝗶𝗱𝗲𝗻𝘁𝗶𝘁𝗶𝗲𝘀 𝗼𝗳 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗮𝘁 𝘀𝗰𝗮𝗹𝗲
𝗚𝗶𝗿𝗮𝘂𝗱 𝗲𝘁 𝗮𝗹. show how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ HD-MEA recordings, combined with their 𝗦𝗽𝗶𝗸𝗲𝗠𝗔𝗣 pipeline, can identify neurons without prior labels, validated through viral and optogenetic methods. A remarkable advance for large-scale electrophysiology.

Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington’s disease animal model Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene. This leads to progressive loss of st…

Check out the publication here: www.sciencedirect.com/science/arti...

Human striatal progenitors can rebuild broken brain circuits.
𝗦𝗰𝗮𝗿𝗮𝗺𝘂𝘇𝘇𝗮 et al. Recently showed that transplanted human striatal progenitors in an HD rodent model survive, differentiate, and integrate, with CorePlate™ HD-MEA recordings revealing some very interesting graft activity!

Our “Recording Organoids with CorePlate™” workshop is now underway, and the energy from our participants has been fantastic. In our Discovery Laboratory, attendees have been exploring hands-on techniques for placing and recording brain organoids and have already found some amazing activity!

Today marks the start of our “Recording Organoids with CorePlate™” workshop, where we’ll be hosting a series of sessions on the best ways to record and interpret activity from brain organoids. We’re excited to welcome our guests for a few packed days of learning, discovery, and fun together!

What an incredible week at #SfN2025! Thank you to everyone who stopped by our booth, attended our Product Theatre, and visited our posters. We loved connecting with you, sharing our passion for electrophysiology and were thrilled to unveil our CorePlate™ enabled 96-well HD-MEA!

Come and see the sneak preview of our new 96-well CorePlate™; precision-designed for advanced disease-in-a-dish modeling. This opens new possibilities for neuroscience and drug discovery. Get an exclusive look - be part of the breakthrough!

#SfN25

Save it to your itinerary: www.abstractsonline.com/pp8/#!/21171...