@zech-lab.bsky.social
Cell Invasion | Mechanobiology | Cytoskeleton | Actin in Ageing | Endolysosomal System | Microscopy @Uni of Liverpool https://tzech6.wixsite.com/zechlab
Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
27.11.2025 09:51 β π 4 π 2 π¬ 0 π 0
Early bird registration: Save Β£100 - 21 January 2026! Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology.
Register now:
bit.ly/Dynamic-Cell-VI
An exciting project to understand cellular ageing in health and disease.
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...
Pls see also our group websites:
TobiasZech: tzech6.wixsite.com/zechlab
β’ Chris Toseland: www.toseland-
lab.com
An exciting project to understand cellular ageing in health and disease. Deadline for applications is 4th Dec. Pis don't hesitate to contact us if interested. https://www.findaphd.com/phds/project/mrc-dimen- doctoral-training-partnership-stopping-premature-ageing: investigating-the-role-of-actomyosin-mediated-nuclear- force-feedback-in-cell-homeostasis/?p189509 Please also see our websites for research interests: Tobias Zech: https://tzech6.wixsite.com/zechlab β’ Chris Toseland: https://www.toseland- lab.com
19.11.2025 12:13 β π 6 π 4 π¬ 1 π 0
Are you interested in studying in the UK for your Masters?
Please join our program director for the MSc Cancer Biology and Therapy at the University of Liverpool for an on-line event.
19th November at 5pm (GMT).
To sign up please use the link below:
lnkd.in/efsXw-ke
The first to be shared is this one: lnkd.in/euACxRhz
With Marisa Merino, co-supervisers Prof. Hilary Ashe & Prof. Harish Poptani.:
Interested in How Organisms Cope with Growth in Challenging Environments? Open to international applicants.
#DevBio #Microscopy #CellBio #PhDPositions #Genetics
A PhD position is available in the lab of @zech-lab.bsky.social co-supervised @christoseland.bsky.social
An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project...
#CellBio #SuperResolutionMicroscopy
#MolecularBio #AgeingResearch #PhDOpportunity
(C) Recruitment of the WT PIKfyve-CCR-Kina to Rab5 endosomes and changes in biosensor localization at these membranes is shown by the fluorescence intensity ratios of the constructs at Rab5 endosomes over the whole cell. Data shown is the grand mean Β± SEM of 3 experiments. A total of 35 cells were analyzed. Confocal images over time are shown to the right. (D) As in C, but now utilizing the catalytically dead K1876E/V1883I mutant of the FKBP-PIKfyve-CCR-Kina as a negative control.
Independent validation of the SnxA biosensor as a sensitive reporter of PI(3,5)Pβ dynamics by Gerald R Hammond and team: www.biorxiv.org/content/10.1...
12.11.2025 18:57 β π 15 π 6 π¬ 0 π 0
π§ Fully funded 4-year PhD studentship π§ Please repost
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
The project is now live on FindaPhD and open for applications. Deadline December 4th
31.10.2025 10:07 β π 2 π 2 π¬ 0 π 0
Vinculin is a simple adapter protein right? Wrong!
Thatβs been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Please Repost!
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
Come and work with us 5-year position available for a University Researcher in Bioimaging 1.11.2025-31.12.2030
abo.rekrytointi.com/paikat/index...
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 𧡠the paper is summarised in this video.
www.biorxiv.org/content/10.1...
Thrilled for the publication of our latest paper on the role of SAS-6 in invasion.
This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends!
@zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles
SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social
www.life-science-alliance.org/content/8/10...
Many congratulations again! Very well deserved
05.06.2025 18:38 β π 1 π 0 π¬ 0 π 0
Keen about High Performance Computing & #imageanalysis? Search for #75 at #ELMI2025 this evening @sebastianmunck.bsky.social⬠@makaefer.bsky.social
05.06.2025 07:03 β π 7 π 3 π¬ 0 π 1
π Are you looking for a postdoc position? Do you think microtubules are fascinating? Then we might have the job for you! 2-year funded postdoc to join our lab!
π deadline 20/06
π check it out
www.godinholab.com
Cover page of the University of Liverpool, Faculty of Health and Life Sciences Strategy 2025-2031 document. The page is black and features a multi-channel microscope image of a mouse embryonic kidney stained for ureteric bud (cyan & yellow) and lumen (magenta). The kidney is surrounded by yellow spots which served as fiduciary markers during lightsheet imaging and give the impression of a starry sky.
The @livunihls.bsky.social has published their strategy 2025-2031. We cannot get past the cover page though: stunning image taken by our very own image analyst @makaefer.bsky.social before she became the image analyst. @livuni-livsrf.bsky.social @bwilm.bsky.social @raphavisses.bsky.social
19.05.2025 12:32 β π 5 π 3 π¬ 1 π 1
Figure showing that MMP in mesendoderm cells is dependent on integrin activation state and signalling.
Gustavo Pacheco, Douglas DeSimone and colleagues discover that mitochondrial membrane potential is spatially regulated in collectively migrating tissue by integrin adhesion and signalling in leader row cells.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Don't miss the First UK Zebrafish Meeting @lsiexeter.bsky.social in Exeter, sponsored by @brukercorporation.bsky.social @brukerspatial.bsky.social al.bsky.social! π Join us Sept 10 - 12. Early bird registration closes soon! Secure your spot. www.exeter.ac.uk/research/ins...
07.05.2025 09:20 β π 12 π 16 π¬ 0 π 2
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that βInterphase cell morphology defines the mode, symmetry, and outcome of mitosisβ - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
06.05.2025 20:39 β π 171 π 48 π¬ 3 π 3
Cartoon of techniques to apply one-dimensional, in-plane or volumetric cell compression in vitro.
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
Interested in how cells respond when squeezed? Check the review paper just published by Laura Faure, @valeriaventurini.bsky.social and myself on this. Really thorough and clear revision by Laura and Valeria!
01.04.2025 15:52 β π 40 π 18 π¬ 0 π 0
Aymen al-Rawi posing with the Node's polaroid frame. The text on the frame reads "#ECR #CircadianRhythm #MassSpec #MRC_LMB"
It's the last day of #biologists100! We'll be sharing more photos of people posing with our polaroid frame.
Aymen al-Rawi @aymen-alrawi.bsky.social is the @bscb-official.bsky.social postdoc rep and organised the #ECR session at Biologists @ 100. His key words are #CircadianRhythm #MassSpec #MRC_LMB
Picture of easels displaying microscopy images.
If you are attending #biologists100, you can now visit our image gallery with @the-node.bsky.social in the exhibition hall and vote for your favourite image.
If you are not at the conference, you can still vote in our poll on FocalPlane: focalplane.biologists.com/2025/03/11/v...
Come and check out our stand at #biologists100 with a chance to enter our mystery prize draw!
@biologists.bsky.social @emilyxlucas.bsky.social @harrietasmith.bsky.social
