Sarah Gawlak

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology Stem cell differentiation is controlled by manipulating RNA condensates.

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du

New research reveals VER inhibits #Osteosarcoma growth by blocking the #PI3K/#AKT pathway both in vitro and in vivo, positioning it as a promising #therapeutic candidate for OS treatment. #DrugDiscovery #CancerTherapeutics #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma https://www.biorxiv.org/content/10.1101/2025.10.24.684275v1

(Re)defining the human chromatome: an integrated meta-analysis of localization, function, abundance, physical properties and domain composition of chromatin proteins https://www.biorxiv.org/content/10.1101/2025.10.10.680841v1

This latest study shows that Yanghe Decoction suppresses #Osteosarcoma (OS) cell processes by inducing #Apoptosis, #MitochondrialDysfunction & boosting #cisplatin sensitivity, promising synergistic approaches to OS treatment. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Now online in Cancer Discovery @aacrjournals.bsky.social: Epigenetic and Transcriptional Programs Define #Osteosarcoma Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, Alejandro Sweet-Cordero, and colleagues doi.org/10.1158/2159... @ucsfchildrens.bsky.social

Acidic transcription factors position the genome at nuclear speckles through transcription dependent and independent mechanisms https://www.biorxiv.org/content/10.1101/2025.10.01.679912v1

Structural variants in the 3D genome as drivers of disease - Nature Reviews Genetics Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects ...

🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularizatio...

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing #Sarcoma Proliferation and Migration

advanced.onlinelibrary.wiley.com/doi/full/10....

CK2 inhibitor CX-4945 targets EWS-FLI1 protein abundance and shows anti-tumor activity in metastatic mouse models of Ewing Sarcoma https://www.biorxiv.org/content/10.1101/2025.09.24.677357v1

Automated FRET Analysis for Enhanced Characterization of Protein-Protein Interactions https://www.biorxiv.org/content/10.1101/2025.09.20.674865v1

Transcriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase https://www.biorxiv.org/content/10.1101/2025.09.02.673849v1

Review: Transcriptomics in the era of long-read sequencing www.nature.com/articles/s41... (read free: rdcu.be/efBjP) 🧬🖥️🧪

Check out our updated preprint!

Using functional #metabolomics, we link reduced EWSR1::ETS activity in Ewing #sarcoma to poor outcome and activation of the AHR pathway, which promotes immune evasion characterized by impaired NK cell function and immunoregulatory infiltrates.

tinyurl.com/2b6cry3m

Nuclei Isolation Protocol for Single-Nucleus RNA Sequencing of Human Stem Cell-Derived Grafts https://www.biorxiv.org/content/10.1101/2025.08.27.672369v1

The evolution of cancer and ageing: a history of constraint Nature Reviews Cancer, Published online: 26 August 2025; doi:10.1038/s41568-025-00861-4In this Perspective, de Magalhães explores the evolutionary relationship between cancer and ageing, proposing that the need to minimize cancer risk early in life may contribute to tissue degeneration later on, representing a trade-off that constrains the evolution of longer lifespans.

NEW content online!

Rules of partitioning - Nature Reviews Cancer Lyons et al. explored the rules of specificity and function for condensates formed by oncogenic fusion proteins, and identified a common molecular signature in these oncoproteins that compartmentalizes RNA polymerase II to confer an increase in gene activation and consequent cancer phenotypes.

#ResearchHighlight 🚨

Ben Sabari ‪@bsabari.bsky.social‬ &Co identified a common molecular signature in oncogenic fusions proteins that compartmentalizes RNA pol II to confer an increase in gene activation and consequent cancer phenotypes.
📖⬇️

Very proud on our stellar Alina Ritter for her frist first-author paper:

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma

tinyurl.com/3kcs3bc9

@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social

Beyond polyA: scalable single-cell total RNA-seq unifies coding and non-coding transcriptomics https://www.biorxiv.org/content/10.1101/2025.08.08.669394v1

Stromal senescence contributes to age-related increases in cancer Nature Reviews Cancer, Published online: 04 August 2025; doi:10.1038/s41568-025-00840-9Ageing influences cancer risk through cellular and environmental changes, including the induction of cellular senescence. In this Review, Ye, Melam and Stewart highlight the role of senescent stromal cells in cancer and the therapeutic implications of this.

NEW content online!

An absolute quantification atlas of small non-coding RNAs across diverse mammalian tissues and cell lines https://www.biorxiv.org/content/10.1101/2025.07.31.667863v1

RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription https://www.biorxiv.org/content/10.1101/2025.07.29.665963v1

NEW content online!

RNA polymerase II transcription compartments — from factories to condensates Nature Reviews Genetics, Published online: 19 June 2025; doi:10.1038/s41576-025-00859-6In this Review, Rippe and Papantonis describe advances in understanding the role of transcription compartments in gene regulation, specifically by collating and contrasting historical work on transcription factories with more recent work on transcriptional condensates.

FYI: New online! RNA polymerase II transcription compartments — from factories to condensates

Study Lays Groundwork for Precision Treatment of HR+/HER2- Breast Cancer Roswell Park investigators uncover evidence that could help make CDK4/6 inhibitors more effective

🔬 Why do some patients respond better to CDK4/6 inhibitors than others?

Roswell Park researchers may have found part of the answer — and it could pave the way for more effective treatment strategies for metastatic HR+/HER2- breast cancer.

📖 Read more: www.roswellpark.org/newsroom/202...

How AlphaFold and related models predict protein-peptide complex structures https://www.biorxiv.org/content/10.1101/2025.06.18.660495v1

Diversity and consequences of structural variation in the human genome - Nature Reviews Genetics Collins and Talkowski provide a broad overview of structural variation in the human genome that covers their mutational properties, the dynamics of population genetics and functional consequences in d...

Our featured article: Diversity and consequences of structural variation in the human genome go.nature.com/4awEtaY #Review by Ryan L. Collins & Michael E. Talkowski @broadinstitute.org @harvard.edu @harvardmed.bsky.social

Transitional lncRNA Signatures Reveal Distinct Stages of Cancer Progression and Metastasis https://www.biorxiv.org/content/10.1101/2025.06.10.658949v1

Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis https://www.biorxiv.org/content/10.1101/2025.06.10.656791v1