Lillemeier lab

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...

Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...

In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️

De novo identification of the specificities of recurrent human T cell receptors https://www.biorxiv.org/content/10.1101/2025.08.03.668342v1

Love this paper from the Cullen and Collins labs! Is cargo sensing for retrieval always coupled to Rabs reegulatory network to move cargo onwards? I think so! #membranetrafficking

If you're a postdoc interested in starting your own group, please consider the Dunn School at Oxford, UK.

It's a fantastic department and university for molecular immunology and all aspects of immune research!

Please share! We hire PIs working in microbiome, metabolism, cancer, allergies, autoimmunity, neurological and infectious diseases. We offer SPF-, gnotobiotic- and wildling-models + generous lab space + top notch equip., e.g. SONY ID7000, 10X Xenium, MACSima. Contact: stephan.rosshart@uk-erlangen.de

NK cells mediate preventive efficacy of intravenous BCG against lung metastasis in mice - Cancer Gene Therapy Cancer Gene Therapy - NK cells mediate preventive efficacy of intravenous BCG against lung metastasis in mice

NK cells mediate preventive efficacy of intravenous BCG against lung metastasis in mice
www.nature.com/articles/s41...

Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2 #Parham #Adams
www.sciencedirect.com/science/arti...

Many congratulations!

three scientists discuss. Text: "MDC Global Fellow postdoctoral program"

Lead your independent research project as a #postdoc in our 3-year #fellowship.

The program includes full-time employment with competitive salary, budget, structured co-supervision, mentoring and advanced training

Apply from August 4 to August 28
👉 www.mdc-berlin.de/postdocs#t-g...

Please share!

Upcoming Event: "From Academia to Industry – Working at Novo Nordisk A/S"
📅 Date: August 21, 2025
🕟 Time: 4:30 p.m.
🎤 Speaker: Dr. Martin Peter
🔗 Register here: gbm-online.de/de/nachwuchs...
Zoom link will be sent to registered participants.
Please share with your postdoc colleagues!

Innate immune mechanisms hijacked by leukemia-initiating stem cells for selective advantage and immune evasion in Ptpn11-associated JMML Zheng et al. demonstrate that hematopoietic stem cells harboring the Ptpn11E76K mutation show de novo activation of the myeloid transcriptional program, resulting in high production of innate immunity...

Activating SHP2 E76K mutation in hematopoietic stem cells drives the myeloid transcriptional program in the resulting
juvenile myelomonocytic #leukemia. SHP2 E76K stem cells show elevated expression of innate immunity-associated proteins, resulting in immune evasion.
www.cell.com/cell-reports...

Two distinct intratumoral cDC1 activation states. Il12b+CCR7+ and enriched at tumour borders, where they closely associate with stem-like TCF1+ CD8 T-cells. CCR7– Cxcl9-cDC1s are preferentially found within the tumour parenchyma alongside effector CD8 T-cells. onlinelibrary.wiley.com/share/FUSAHT...

Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice
@natcomms.nature.com
www.nature.com/articles/s41...

CD40 agonistic-monovalent streptavidin fusion antibody for targeted neoantigen peptide delivery and potent cancer vaccination https://www.biorxiv.org/content/10.1101/2025.07.30.663779v1

Associate Editor or Senior Editor, Nature Methods Title: Associate or Senior Editor, Nature Methods Organization: Nature Portfolio Locations: New York, Jersey City, Shanghai or Beijing Closing Date: August 3, 2025    About Springer Nature Springer Na...

Nature Methods is also hiring to replace me (applications close August 4th!!!) and I will do everything I can to support their next bioimaging editor (ask me anything!). springernature.wd3.myworkdayjobs.com/SpringerNatu...

CD45 sequestration lowers the signaling threshold in lymphocytes and enhances anti-tumor immunity https://www.biorxiv.org/content/10.1101/2025.07.29.667400v1

PD-1 is requisite for skin TRM cell formation and specification by TGFβ Nature Immunology - Anandasabapathy and colleagues show that the inhibitory receptor PD-1 impacts the specification of tissue-resident memory T cells in the skin.

#PD-1 signaling strongly impacts the early specification of tissue resident memory CD8 #T-cells (TRM) in the skin. PD-1 supports early TRM cell colonization, skin-specific programming and silencing of other differentiation programs and promotes TGFβ responsivity and skin engraftment.

rdcu.be/eyP9p

Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa Job offer Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!

▶️▶️ To all mass spec enthusiasts: A postdoc position (three years) is available in our international group. Please apply if you are interested in structural MS and in developing novel cross-link ing MS workflows!🧪
Thanks @diegofgar.bsky.social for sharing!
#teammassspec
#AcademicSky
#ChemSky

💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules

We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.

Please share broadly, thank you!🤝

schmid.chemie.unibas.ch

A nice place to be!
Highly recommend!
I would love to be student again and work with Sebastian ;-)

Preprint: SATB1 maintains naive identity in antiviral CD8 T by limiting chromatin remodeling at effector gene loci @sjturn.bsky.social
www.biorxiv.org/content/10.1...
Hence, SATB1 modulation may improve immunotherapeutic CD8 T longevity and self-renewal capacity

Preprint: CAR T cell cytotoxic responses are rapidly generated and sensitive to the unligated TCR
www.biorxiv.org/content/10.1...

Regulation of YAP activity by nuclear G-actin binding The Yes-associated protein YAP belongs to the TEAD (TEA/ATTS domain) transcriptional co-activators that shuttle between cytoplasm and nuclear compartment. YAP and its paralog TAZ (transcriptional co-a...

Hi all, check out our new preprint where we uncover:"Regulation of YAP activity by nuclear G-actin binding", www.biorxiv.org/cgi/content/...
#actin #YAP/TAZ #transcription #nucleus with help from Sonja-Verena Albers
‪@archaellum.bsky.social‬

‘Smart’ tool pieces together proteins in response to combinations of cell-surface cues facilitating precision target recognition @nature.com #MuirLab
www.nature.com/articles/d41...
www.nature.com/articles/s41...

Associate or Senior Editor, Nature Biomedical Engineering Job Title: Associate or Senior Editor, Nature Biomedical Engineering Organization: Nature Portfolio Location: New York, Jersey City, Shanghai or Beijing – Hybrid Working Closing date: August 20, 2025 ...

My colleagues at Nature Biomedical Engineering @natbiomedeng.nature.com are hiring an associate or senior editor. Ideal applicant will have expertise in immunology, immunotherapy, or immuno-oncology.

Please feel to ask me questions!

springernature.wd3.myworkdayjobs.com/SpringerNatu...

Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.

After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.

* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity Lambert et al. describe an antibody-based approach targeting the pleiotropic TGF-β1 cytokine in a manner unexplored thus far. At variance with existing TGF-β1-targeting strategies aiming to block TGF-...

TGF-β1 is an immunosuppressive cytokine present on surafce of most immune cells in an inactive latent form. Latent TGF-β1 can be activated by monoclonal antibodies. This antibody-mediated TGF-β1 activation shows therapeutic effects in graft versus host disease.
www.cell.com/cell-reports...

Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer Pancreatic ductal adenocarcinoma is an aggressive cancer characterized by an immunosuppressive tumor microenvironment and limited therapeutic options. Mahat et al. show that a prevalent p53 mutation d...

p5353 missense mutations in pacreatic #cancer lose their wild-type tumor-suppressor function. p53 R172H shows gain-of-function oncogenic role, as it upregulates immunosupressive chemokine expression and impaires the efficacy of immune checkpoint inhibitors.
#ImmunoSky
www.cell.com/immunity/ful...