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Lillemeier lab

@lillemeier-lab.bsky.social

We are a research group at University of Freiburg that studies the molecular mechanisms of T cell activation and how to use them for immunotherapy. https://lillemeier.biologie.uni-freiburg.de/

223 Followers  |  202 Following  |  140 Posts  |  Joined: 24.01.2025
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Posts by Lillemeier lab (@lillemeier-lab.bsky.social)

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Benchmarking EGF signaling pathway inference using phosphoproteomics and kinase-substrate interactions - Nature Communications To what extent can large-scale approaches accurately reconstruct classic signaling pathways? Here, authors revisit the EGF pathway using phosphoproteomics and kinase-substrate interactions

Is the linear map of cell signaling a myth?
New research suggests the reality of cellular networks is more complex.
@savitski-lab.bsky.social & @saezlab.bsky.social combined experimental and computational expertise to test how we map kinase–substrate interactions.
www.nature.com/articles/s41...

05.03.2026 09:57 β€” πŸ‘ 7    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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We have three exciting opportunities for you to join us for a fully-funded 4-year #PhD project here in #Manchester starting in October 2026

Find full details of all the projects on our website: www.cruk.manchester.ac.uk/phd-student-...

Applications close 3rd April 2026

05.03.2026 10:25 β€” πŸ‘ 3    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Congrats Mary Carrington #NCI @ragoninstitute.bsky.social!
HLA class I signal peptide variation predicts strength of NKG2A+ NK cell response to missing-self and risk of human disease @natimmunol.nature.com
www.nature.com/articles/s41...

04.03.2026 20:35 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Have a look at this PhD program in Vienna- most interesting science and the best training program:

03.03.2026 10:18 β€” πŸ‘ 1    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
Laboratory Manager Click the link provided to see the complete job description.

The Mettelman Lab at the University of Pittsburgh Center for Vaccine Research has officially opened its doors, and I’m looking to hire a Lab Manager!

If interested, please apply using the link below

Come join our team of 1!

cfopitt.taleo.net/careersectio...

04.03.2026 21:34 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Lytic IFNΞ³ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing
www.nature.com/articles/s41...

05.03.2026 03:33 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Postdoc Ad Postdoctoral Position in Computational Phage Biology Microbial Genomics Group, Malopolska Centre of Biotechnology (MCB), Jagiellonian University, KrakΓ³w PL Summary We are seeking a postdoctoral rese...

πŸ“’ Hiring a Postdoc in Computational Phage Biology (KrakΓ³w, Poland)

We study the evolution & structural modularity of prophage-encoded glycan-degrading enzymes in Klebsiella pneumoniae β€” combining genomics and AlphaFold-based analyses.

Details in attached PDF πŸ‘‡

26.02.2026 08:44 β€” πŸ‘ 10    πŸ” 12    πŸ’¬ 1    πŸ“Œ 0
PhD Student (gn*) Neuro-Immunology PhD Student (gn*) Neuro-Immunology

Join us in MΓΌnster to study the immunology of cerebrospinal fluid and the meninges in a human-centric fashion – apply for PhD student position here:
jobs-sf.ukmuenster.de/job/UKM-PhD-...

04.03.2026 12:34 β€” πŸ‘ 1    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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🚨 #postdoc to be hired in the Paluch Lab 🚨

If you know anyone experienced with and, more importantly, excited about nanoscale architecture of #actincortex and super-res & electron #microscopy do encourage them to applyπŸ‘‡

Amazing colleagues, can only recommend πŸ˜‰

www.cam.ac.uk/jobs/researc...

03.03.2026 15:50 β€” πŸ‘ 11    πŸ” 12    πŸ’¬ 0    πŸ“Œ 0

Spring cleaning in the lab - don’t forget your microscope!

04.03.2026 11:28 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Open positions | Neuroimmunology Munich

JOB ALERT πŸ“£ #PhD #position in #autoimmunity and #stroke.
The Kawakami lab in the BMC is seeking a highly motivated #PhD #candidate to investigate how T cells drive inflammation in the central nervous system.

Deadline: 31.03.26
More ➑️ www.neuroimmunology-munich.de/open-positio...

03.03.2026 13:33 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

New #CIBSS publication from the Jessen Lab!
πŸ‘‡

03.03.2026 07:49 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Technical Assistant

Are you interested in working with a fresh team on cutting edge protein design?
We're hiring a Technical Assistant for our protein design team at DKFZ Heidelberg: jobs.dkfz.de/en/jobs/1683...

Please share!

02.03.2026 07:35 β€” πŸ‘ 10    πŸ” 10    πŸ’¬ 0    πŸ“Œ 2
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πŸ“£ #EFIS Education Task Force invites you to another webinar in the "Landmark Discoveries in Immunology" series!

πŸ’₯ Registration is free πŸ‘‡
πŸ”— www.efisedu.de/webinar
πŸ—“οΈ March 5 at 17:00 CET

✨ Share and invite your colleagues!
#immunology #NKCells #ImmunologyEducation

@yefis-immunology.bsky.social

02.03.2026 10:21 β€” πŸ‘ 6    πŸ” 5    πŸ’¬ 1    πŸ“Œ 1
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Would you like to study membrane organization, dynamics, and cell death? 🧬 Check out the García-SÑez Group ( @office-garcia.bsky.social , @mpibp.bsky.social )

πŸ—“ Application deadline: March 11 πŸ‘‰ imprs-cbp.mpg.de/call-for-app...

#imprs_cbp #membranebiophysics #apoptosis

27.02.2026 21:22 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Cytokine specificity in macrophages: JAK-STAT and beyond Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation is resolved or sustained.

Cytokine specificity in macrophages: JAK-STAT and beyond #immunology

27.02.2026 18:15 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Tumor reactivity assessment using clonal expression (TRACE) reveals tumor reactive CD8+ T cell heterogeneity across solid tumors https://www.biorxiv.org/content/10.64898/2026.02.25.707942v1

27.02.2026 04:16 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Building Motifs

Interested in understanding how epitope recognition specificity is encoded in your TCR sequences? Try our new interactive page for building TCR specificity profiles on the TCR Motif Atlas: tcrmotifatlas.unil.ch/Building_mot....

26.02.2026 11:04 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
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Excited to announce the 1st International Conference on T cells in Health and Disease, a new conference series aiming to bring together T cell biologists across diverse areas, from fundamental biology through to clinical translation, and spanning infection, autoimmunity and cancer.

26.02.2026 10:55 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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Review @cp-cancercell.bsky.social @harvardmed.bsky.social
Overcoming functional and translational challenges of cellular immunotherapies for solid tumors
www.cell.com/cancer-cell/...

26.02.2026 19:53 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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You are interested in immunology and how nucleic acid structures contribute to their function and how this impacts disease development - Rayk Behrendt and myself have open PhD positions for a joint PhD program between Bonn and Osaka.

25.02.2026 11:05 β€” πŸ‘ 3    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition Equipping T cells with fungal enzymes to utilize cellobiose (a safe and natural disaccharide of glucose obtained from the wood polymer cellulose) enhances their viability and effector function in tumo...

I'm so excited to share our new paper in Cell where we provided T cells two genes that allow metabolism of a safe form of glucose (derived from cellulose). This fuel allows human CAR-T cells to fight tumors better! Congrats go to Matt Miller, now a postdoc at Salk. www.cell.com/cell/fulltex...

25.02.2026 00:44 β€” πŸ‘ 7    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
International Symposium – March 23-25, 2026 : SFB 1381

The 2nd International Symposium of our SFB is coming up soon - registrations ends this Friday, Feb 27, so hurry and sign up if you'd like to join!

www.sfb1381.uni-freiburg.de/symposium2026

24.02.2026 14:09 β€” πŸ‘ 3    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion @frontiersin.bsky.social
www.frontiersin.org/journals/imm...

24.02.2026 16:40 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory - Nature Immunology Schober and colleagues show that effector CD8+ T cells undergo metabolic shutdown, CD8+ central memory T cells are the most metabolically active, and naive-like memory T cells are quiescent during the...

New work from our lab, hot off the press in Nature Immunology (@natureportfolio.nature.com)!

How do human T cell responses diversify β€” and how does this lead to durable protection after vaccination?

Paper: www.nature.com/articles/s41...

Press release: www.fau.eu/2026/02/news...

1/6

24.02.2026 10:01 β€” πŸ‘ 29    πŸ” 11    πŸ’¬ 1    πŸ“Œ 0
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Postdoc Research Group Schur The Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID. Our Group ...

Open Postdoc position in our lab!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.

ista.ac.at/en/job/postd...

Please share and feel free to reach out if there are questions!

13.02.2026 15:50 β€” πŸ‘ 32    πŸ” 19    πŸ’¬ 1    πŸ“Œ 2

πŸŽ‰ New #CIBSS publication!

Dr. Daria @onichtchouk.bsky.social reveals how chromosome structure is organised at the very start of life. Using zebrafish, the team shows how DNA architecture forms as embryos activate their genomes.

πŸ”—https://kurzlinks.de/gwuu

#Chromosomes #Embryogenesis #SignalsOfLife

23.02.2026 10:35 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1

#lipidtime

23.02.2026 00:51 β€” πŸ‘ 34    πŸ” 7    πŸ’¬ 0    πŸ“Œ 1

I’m looking to hire a research technician for my lab at Harvard & DFCI, who would primarily work in the wet lab expressing and characterizing designed proteins, starting this summer. A great role for a recent college grad looking for an immersive research experience before grad school.

20.02.2026 14:33 β€” πŸ‘ 11    πŸ” 13    πŸ’¬ 1    πŸ“Œ 0
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π™ˆπ™šπ™’π™—π™§π™–π™£π™šπ™¨ 𝙖𝙣𝙙 π™©π™π™šπ™žπ™§ π™‘π™žπ™₯π™žπ™™π™¨ 𝙖𝙣𝙙 π™₯π™§π™€π™©π™šπ™žπ™£π™¨ π™žπ™£ π™€π™§π™œπ™–π™£π™šπ™‘π™‘π™š π™—π™žπ™€π™œπ™šπ™£π™šπ™¨π™žπ™¨ - Spetses, Greece - May 2026 | Utrecht University Utrecht University

CALLING PHDs AND POSTDOCS! Apply for the 20th FEBS/EMBO summer school on Membranes lipids & proteins in organelle biogenesis! Spend a glorious week with leaders in the field on the beautiful island of Spetses in Greece this May. Registration: spetses2026.sites.uu.nl @embo.org @febspress.bsky.social

20.02.2026 11:16 β€” πŸ‘ 11    πŸ” 10    πŸ’¬ 0    πŸ“Œ 0