Andrew Hardaway

These brain cells clear proteins that contribute to Alzheimer’s When specialized cells called tanycytes stop working, disease-causing tau proteins build up in the brain.

When specialized cells called tanycytes stop working, disease-causing tau proteins build up in the brain.

go.nature.com/4ldhrez

a little girl is sitting on top of an orange slide and says `` bye bye weird lady '' . ALT: a little girl is sitting on top of an orange slide and says `` bye bye weird lady '' .

*Kristi Noem singing in a Neil Young-voice to Jeff Sessions*

"Old man look at my life, I'm a lot like you were...."

a little girl is sitting on top of an orange slide and says `` bye bye weird lady '' . ALT: a little girl is sitting on top of an orange slide and says `` bye bye weird lady '' .

*Kristi Noem singing in a Neil Young-voice to Jeff Sessions*

"Old man look at my life, I'm a lot like you were...."

New Count of Monte Cristo miniseries on PBS? Yes please!

Was curious about new model so today we demo'd the Keyence BZX-1000. Amazing machine. Improved speed and UI. Amazing how much tech has evolved over my career with the ultimate effect of improving accesibility and throughput of high quality microscopy for biomedical research labs. #neuroskyence

oh GREAT now i have to completely rewrite my script "Fuck Plane"

a pixelated image of a man with a mustache and the words well Alt: a pixelated image of a man with a mustache and the words well

www.wsj.com/politics/pol...

A photo of Doc Brown from Back to the Future holding jumper cables labelled "Deranged Activist" with a grant of NIH funding curves below it.

My weekly update on NIH funding

This includes awards made through 2/27/26

Warning: This thread contains data compiled by a known deranged_activist™. Do not read while operating heavy machinery.

1/9

Just don't get to 88 mph Jeremy or we gonna see some real shit.

Methodist minister, National guardsman.

a cartoon drawing of a bear wearing a brown hooded cloak ALT: a cartoon drawing of a bear wearing a brown hooded cloak

Me:

a close up of a snake 's face with hypnotic eyes Alt: a close up of a snake 's face with hypnotic eyes

LinkedIn trying to tell you about the merits of AI in the workplace.

But freedom of speech, diversity of viewpoints, blahbity blah bah Rufo talking point where the shoe is now on the other foot yadda yadda!

a large screen shows a man 's face and says ingsoc ALT: a large screen shows a man 's face and says ingsoc

So... A friend was supposed to give a PURELY SCIENTIFIC talk at NIH within the next couple of weeks and it was cancelled because of a "new process" where all speakers/talks have to be CLEARED BY A POLITICAL APPOINTEE.

A neuromodulatory circuit-to-molecular pathway for reformatting aversive memories during recall Tan et al. identify a neuromodulatory circuit-to-molecular pathway in rats that updates aversive memories when they are recalled. Noradrenaline from the locus coeruleus triggers synapse-to-nuclear tra...

Excited to share our new paper:
We uncover a locus coeruleus→amygdala circuit linking β-adrenergic signaling to transcription regulation in defined amygdala cells during memory reconsolidation—+ stress or elevated noradrenergic signaling at recall can strengthen memory.
www.cell.com/neuron/abstr...

Check our @russpoldrack.org's series Better Code, Better Science, a really amazing resource bettercodebetterscience.github.io/book/

The UAB Heersink School of Medicine is seeking to recruit up to 16 new research-intensive faculty as part of a major strategic investment in neurosciences. Faculty will be housed in a brand new research facility at the heart of campus, which is scheduled for completion this summer.

That would make a lot of sense. Maybe we will get a NIH blog post explanation

Ah I see.

Thanks Kurt. I was too quick on the draw responding. Do we think this is partially in response to volume of apps? Recently there have been efforts to redistribute grants for feeding, obesity, metab to try due to volume but never a restructure this expansive. Its interesting.

Whoa. PMDA also has that note.

BNRS, NIC, POMD, and MCNP do not.

NAL is dead

NMB is dead

ARM is dead

a bald man is sitting in a chair with #fallontonight written on the bottom right ALT: a bald man is sitting in a chair with #fallontonight written on the bottom right

I will be using this skeet to sell a midbrain project to an unsuspecting grad student.

I'll let you know when I find actual cells

Why do you degnerates like to work in the midbrain? Horrible place to patch.

☎️Daily Action Call, Monday, March 2nd, Oppose Anti-Vax Influencer Casey Means for US Surgeon General ☎️ ⁣ ⁣ 📚 Background 📚 👉🏻The Surgeon General plays an Important role in public health, as the leading spokesperson on public health and oversees the US Public Health Service Commissioned Corps, a team of over 6,000 public health professionals. 👉🏻President Donald Trump’s latest US Surgeon General nominee, wellness influencer Casey Means, has a lapsed medical license and a concerning history of promoting lies about life-saving childhood immunizations. 👉🏻Means has correctly expressed alarm over the troubling epidemic of chronic illnesses in the United States. However, many of her proposed remedies, from raw milk to the aforementioned reduction in childhood vaccinations to dubious supplements that she sells, ignore the root causes of poor health in pursuit of pseudoscientific “cures” that conveniently make her money. 👉🏻Means is an Anti-Vax sycophant who belongs nowhere near the Department of Health and Human Services, particularly amid an accelerating deadly measles outbreak. 👉🏻A credible leader in public health is essential in this role, as the Surgeon General works to protect the health of the entire country. The Senate must demand a competent, scientifically grounded appointee for our nation’s doctor. 📱 Senators Hi, my name is [NAME] and I’m a constituent from [CITY, ZIP]. I’m calling to urge [SEN NAME] to oppose Casey Means' appointment to US Surgeon General. Means is an influencer with a lapsed medical license who has promoted dangerous lies about childhood vaccines. She is wholly unfit for the Surgeon General position. We need a credible public health leader who is competent, scientifically grounded and will work to protect the health of the entire country. 📣EVENTS: Birmingham Indivisible Public page More/Events for links/flyers⁣ ❗️MARK YOUR CALENDAR:⁣ 🗓️ Saturday 3/28 NO KINGS 3, Railroad Park ⁣

1/3📢March 2 Daily Action☎️
❌OPPOSE ANTI VAX CASEY MEANS 4️⃣US SURGEON GEN❌
✳️ 5calls.org/issue/casey-...
🚫NO WAR IN IRAN🚫
✳️ 5calls.org/issue/iran-i...
❤️‍🔥Epstein Cover 🆙
AKA WAR w IRAN
AKA EPSTEIN FURY
✳️ www.npr.org/2026/02/24/n...
SCRIPT👇🏼
#NOWARWITHIRAN
#NOWAR
#ENDFOREVERWAR
@alreporter.com
@al.com

I have never seen a politician more directly copy this speech in my life

A children's hospital is renamed for Dolly Parton and hopes to transform pediatric care in Tennessee Dolly Parton’s name might inspire full-throated sing-a-longs to her working woman’s anthem “9 to 5,” or evoke memories of thrilling days spent at her Dollywood theme park.

“Dolly Parton Children’s Hospital did not share how much Parton donated as part of the naming announcement. But Matt Schaefer, its president and CEO, said her support would ensure ‘every child who walks through our doors receives the treatment they deserve.’”

GOD BLESS DOLLY PARTON

Old enough to remember when the US had a diplomatically-negotiated nuclear deescalation deal in place with Iran. This is a huge mistake.

Side-by-side image of Will Ferrell and Chad Smith sitting on a talk show set, both wearing backward blue baseball caps and black leather jackets, with nearly identical serious expressions. The background shows a nighttime city skyline from The Tonight Show Starring Jimmy Fallon set. Overlaid text on the left image reads “2001 Iraq War propaganda,” and on the right image reads “2025 Iran War propaganda,” framing the two similar images as a comparison meme.