Silvia Anderle

Thank you Lewis 😄

Thank you Kira, I hope you find the read interesting 😊

Delighted to welcome a new Group Leader to our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏

Prof Catherine Hall @cathnaledi.bsky.social and her team will examine how changes in blood flow & oxygen supply drive the onset of vascular dementia & Alzheimer’s👉 buff.ly/gyouoEV

Thanks Axel! 😊

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...

We're excited to welcome a new Group Leader to our vascular dementia research centre with the BHF🎉👏

Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz

Come and join us in Manchester... We are looking for candidates interested in vascular health and neurodegeneration. This project is specifically exploring how menopause may increase Alzheimer's risk.
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.

Apply here 👇
bit.ly/44AFJHx

Frontiers | Walking on the tightrope: the shared roles of the bridging pericytes in the brain The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...

🚨 Review Alert

*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*

Congratulations Audrey Chagnot!! 🥳

Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊

www.frontiersin.org/journals/cel...

Vittani, Lee, Wang, Hiraoka, et al.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025...
We hope this method is useful to a wide range of the biology community.

Spatial Transcriptomics and Proteomics Profiling After Ischemic Stroke Reperfusion: Insights Into Vascular Alterations | Stroke BACKGROUND: More than half of patients with ischemic stroke experience futile reperfusion, increasing the risk of death and disabilities despite a successful recanalization. The reason behind this is ...

www.ahajournals.org/doi/abs/10.1...

Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter - Nature Neuroscience White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggestin...

www.nature.com/articles/s41...

@physoc.bsky.social has a starter pack of physiologists. Hooray!! go.bsky.app/2KU1XD6

Welcome! 🥳♥️

My first first author paper is finally out! 🎉 Go check it out or read the fantastic blue-torial put together by @cathnaledi.bsky.social 😍 hope you enjoy the read and let us know what you think! 😊

Thank you Craig 🙌🏼

Outstanding and inspiring study!

Norepinephrine (NE)-mediated slow vasomotion drives glymphatic clearance during sleep

www.cell.com/cell/fulltex...

- NE release drives slow vasomotion in NREM sleep

- NE oscillations trigger opposing changes in blood/CSF volumes & predicts glymphatic clearance

Endothelial inflammation in COVID-19 Disrupted endothelial function underlies the multiorgan complications of COVID-19

Infection with #SARSCoV2 has highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of #COVID19 and potentially to the longer-term consequences associated with #LongCovid.

Learn more in a new #SciencePerspective:

Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats Numerous epidemiological and preclinical studies have established a strong correlation between type 2 diabetes (T2DM) and cognitive impairment and T2D…

Some of our work: "Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats"

#neurovascular #cognition
#nitricoxide #diabetes

www.sciencedirect.com/science/arti...

🎉A bit late to the party, but happy to be joining this community!

💫The Down syndrome and Alzheimer’s disease PIA has put together a webinar on cerebrovascular pathology in DS and AD. Please join us on Zoom on Friday 13th, 10:30 am PST, 12:30 CT USA.

✏️Register here: alz-org.zoom.us/webinar/regi...

I guess it was about time to ditch X.
Hello Bluesky! 👋🏼

For more on this subject, follow the researchers in the following starter packs:

Pericytes: go.bsky.app/GhVdxzC

Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy

Cardiovascular research: go.bsky.app/SgaGkv5

For more on this subject, follow the researchers in the following starter packs:

Pericytes: go.bsky.app/GhVdxzC

Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy

Cardiovascular research: go.bsky.app/SgaGkv5

Neuroimmunology: go.bsky.app/Eaua5Jk