János Péter Mészáros

Palladium(II) Complexes with Noncovalent Interactions with DNA: Solution Speciation Controlled by Solvent Identity, pH, and Concentration The coordination capacity of thiosemicarbazone ligands and their synergism with palladium(II) ions modulate their reactivity, allowing custom design. Using thiosemicarbazones with two potential stable tautomeric forms and imidazole as bioisosteres, we studied how the substitution in the N4 group of the thiosemicarbazone by the p-chlorophenyl group modifies their hydrophilic properties, integrity in solution, and interactions toward their potential targets. The coordination to Pd(II) affects the bioactivity of the ligands, resulting in either improved or reduced antiproliferative effects depending on the cell type (cancerous versus bacterial, respectively).

New publication alert! 📢 pubs.acs.org/doi/10.1021/...
In this work we studied Pd(II) thiosemicarbazone complexes with anticancer activity. 💊
A big thank you to all the collaborators!
#chemistry #cancer #palladium #TSC

14.11.2025 12:30 — 👍 1    🔁 0    💬 0    📌 0

Stability and Pseudocatecholase Activity of Artificial Bis-Histidyl Copper Peptides In this paper, 4-methylcatechol (4-MC) and L/D-Dopa are selected as target substrates for de novo protein design, serving as a proof-of-concept system for evaluating the catalytic activity of metal co...

New publication in the group!
Authors: Chiara Bottoni, Matteo Tegoni and Valentina Borghesani*
Stability and Pseudocatecholase Activity of Artificial Bis-Histidyl Copper Peptides pubs.acs.org/doi/10.1021/...
#SpyTag #copper #catalysis #peptide

09.10.2025 08:18 — 👍 1    🔁 0    💬 0    📌 0

30.09.2025 13:49 — 👍 0    🔁 0    💬 0    📌 0

We constructed an RGBW photoreactor in the summer in order to perform photocatalytic reactions in the TegoniLab. A test reaction was done, improvements on the cooling were implemented. See the beautiful crystalline product in the comments! :) #UNIPR #photochem #DIY

30.09.2025 13:48 — 👍 1    🔁 0    💬 1    📌 0

Interesting talks in the 2025 Repurposed & Artificial Enzymes Conference in the beautiful city of Basel. #repartzymes #basel

27.06.2025 05:41 — 👍 5    🔁 0    💬 0    📌 0

Uppsala University main building and SLU Campus Ultuna, a great place for the ISABC17 conference!

17.06.2025 12:08 — 👍 3    🔁 0    💬 0    📌 0

ISABC17 started in Uppsala University! #isabc #isabc17 #bioinorganic

16.06.2025 08:53 — 👍 2    🔁 0    💬 0    📌 0