Roham Parsa

Illustration showing how T cells, when activated, turn on a red fluorescent protein and migrate through the bloodstream to three organs - lungs, lymph node, spleen – taking on different roles in different tissues.

New in Nature Immunology: @rohamparsa.bsky.social & @danmucida.bsky.social / @rockefeller.edu reveal that where a T cell gets activated shapes what it becomes, foundational to our mission of programming immunity for early disease detection.

Read more ▶️
biohub.org/blog/track-t...

A new tool from Rockefeller's @danmucida.bsky.social and @czbiohub.bsky.social allows scientists to closely follow newly activated T cells as they travel and change during an infection—it may inform future therapies for infection, cancer, and autoimmunity.

🔗: https://bit.ly/3NjZEWD

Group Leader, Immunology New York, NY (Hybrid)

We’re recruiting a talented immunologist to launch a lab at Biohub New York. If you’re excited about bold science in a collaborative, well-supported environment, we’d love to hear from you.

job-boards.greenhouse.io/biohub/jobs/...

Research Associate, Immune Cell Dynamics and Function New York, NY (Onsite)

We are looking for a motivated Research Associate to join our lab and help us decode the immune system! If you have any questions please reach out! #science #immunology #STEMjobs

job-boards.greenhouse.io/biohub/jobs/...

Amazing postdoc opportunity in beautiful Stockholm! Great PI!

Fungal Pathogens: Emerging Threats and Future Challenges | Keystone Symposia Join us at the Keystone Symposia on Fungal Pathogens: Emerging Threats and Future Challenges, January 2026, in Breckenridge, with field leaders!

Just a few days left for scholarship and short talk submissions!
Science, snow, and exciting advances in fungal and immunology research🔬 🍄❄️Claim your spot! #KSFUNGALPATH26 www.keystonesymposia.org/conferences/...

Many thanks to @danmucida.bsky.social and all our co-authors for their contributions to this work!

We believe these findings provide important insights into how T cells adapt across organs and how tissue cues shape both their function and clonal expansion. We also hope that TRACK mice will be a valuable tool for the scientific community studying T cell dynamics in health and disease.

Interestingly, early clonal segregation during infection evolved into greater inter-organ sharing, leading to clonal equilibrium over time, likely driven by retrograde migration previously reported in CD8 T cells. Additionally, TCR specificity converged on a few viral proteins at the memory stage.

During viral infection, different tissues, including secondary lymphoid organs, not only shape the transcriptional profile of CD4 T cells but also control the expansion of specific clones, likely driven by TCR specificity and each tissue’s unique antigen landscape.

The novel TRACK mice we developed allow us to carefully follow recently activated, antigen-agnostic polyclonal CD4 T cells during perturbations (controlled by tamoxifen) and determine how they are clonally selected and transcriptionally defined across organs.

Excited to share our new preprint! We studied how T cells are functionally & clonally shaped across organs over time. With the new TRACK mice, we genetically label recently activated T cells with tdTomato and track their migration across tissues. #immunology #science www.biorxiv.org/content/10.1...

ICQ !!!

One project is to determine how T cells adapts to various tissue environments and how long this information is stored within the cell. The second project is to develop novel tools to track T cell migration across organs.

Please spread the word! #postdoc #STEMjobs #sciencejobs #czbiohub

Research Scholar, T cell Tissue Adaptation and Residency (Parsa Group - Biohub NY) New York, New York, United States

Hi, we are looking for two motivated postdocs to join our group!

job-boards.greenhouse.io/chanzuckerbe...

job-boards.greenhouse.io/chanzuckerbe...

In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313 Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…

🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇

sciencedirect.com/science/arti...

Congrats Justin! Amazing work

Career Opportunities at the CZ Biohub Network Find job openings at the CZ Biohub Network.

We're recruiting new Group Leaders and Platform Leaders at Chan Zuckerberg Biohub New York! Our mission: to decode and understand the language of the immune system to better detect and treat cancer, autoimmunity, and neurodegenerative diseases.

www.czbiohub.org/careers/?loc...

#newPI #ScienceJobs

Identification of antigen-presenting cell–T cell interactions driving immune responses to food The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...

I am excited to share our study showing how the immune system strikes a delicate balance between tolerating food and defending against helminth infections.
www.science.org/doi/10.1126/....

Beautiful work from my talented friend @cicacanesso.bsky.social

Research Associate - Parsa Group New York, New York, United States

We are looking for a Research Assistant! Come and build a great science team with me! #STEMjobs #ImmunoSky

job-boards.greenhouse.io/chanzuckerbe...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Mug competition with @cyrilpedia.bsky.social , gift to me from @danmucida.bsky.social lab, immunologists best friend

Santa came early this year :) #newPI

Anyone knows where I can find some influenza PR8 proteins, specifically - M2, PB2 and PA… I’ll send you some top quality Swedish candy :)

Problem choice and decision trees in science and engineering Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for eva...

Here is the commentary published in Cell regarding this topic!

www.cell.com/cell/abstrac...

Great podcast! Everyone—graduate students, postdocs, and new PIs—should listen to this episode!

And as a bonus—the position is based in the heart of New York City! Beyond the exciting scientific opportunities, you’ll have access to the vibrant, culturally rich, and inspiring environment that makes New York such an extraordinary place to live and work.

CZ Biohub NY is affiliated with three powerhouse institutions—The Rockefeller University, Columbia University, and Yale University. This provides opportunities to engage with leading scientists, attend world-class lectures, and access cutting-edge technologies across these institutions.

I’m looking for a postdoc to join my group here at Chan Zuckerberg Biohub NY! This position offers the chance to delve deeply into the dynamic and functional behavior of T cells, exploring how their fate decisions shape immune responses in health and disease.

More information at parsalab.science