Kidney International

Commentary
Metabolic heavyweight: thick ascending limb or proximal tubule? Next round
✍️Kevin A Hurtado and Leslie S. Gewin

doi.org/10.1016/j.kint.2025.08.010

Original article: doi.org/10.1016/j.kint.2025.07.021

#MedSky #NephSky @washunephrology.bsky.social #aki #acutekidneyinjury

Commentary
Underappreciated hard worker: resident macrophage patrols and controls local inflammation in kidney
✍️Ryo Yamada and Motoko Yanagita

doi.org/10.1016/j.kint.2025.08.005

Original article: doi.org/10.1016/j.kint.2025.07.022

#NephSky #MedSky #acutekidneyinjury

A national cohort study examined the risk of severe infection and infection-related mortality in patients with chronic kidney disease with lupus nephritis in comparison to other chronic kidney disease etiologies

doi.org/10.1016/j.kint.2025.10.010

#OpenAccess #MedSky #NephSky #ckd @ki.se

Renal hemosiderosis secondary to intravascular hemolytic anemia

doi.org/10.1016/j.kint.2025.05.033

🔹Rare case of secondary renal hemosiderosis after valve surgery
🔹Beautiful histology, Prussian blue, and EM images showing hemosiderin deposit

#MedSky #NephSky @umontreal-en.bsky.social

Commentary
Round and round we go: phosphoenolpyruvate carboxykinase 1 (PCK1) in cataplerosis, mitochondrial, and kidney health

Mitchell A Sullivan and Josephine M Forbes

doi.org/10.1016/j.kint.2025.08.006

Original article: doi.org/10.1016/j.kint.2025.06.018

#NephSky #MedSky #kidneydisease

KI Commentary
The coming of age for polycystic kidney disease
Uyen A. Tran and Olivier Wessely

doi.org/10.1016/j.kint.2025.08.001

Original article: doi.org/10.1016/j.kint.2025.05.027

#ADPKD #NephSky #MedSky @clevelandclinic.bsky.social @casewestern.bsky.social

Early diagnosis of #POEMSsyndrome prompted by skin findings and bone window computed tomography

doi.org/10.1016/j.kint.2025.05.032

🔹This case demonstrates the importance of subtle skin findings and imaging interpretation in rare disease diagnosis.

#NephSky #MedSky #kidneydisease

REMODELing Mechanistic Trials for Kidney Disease: a multi-modal, tissue-centered approach to understand the renal mechanism of action of #semaglutide

doi.org/10.1016/j.kint.2025.10.005

#OpenAccess #MedSky #NephSky #CKD #diabetes @uwnephrology.bsky.social @umich.edu @kidney-resrch-inst.bsky.social

From progression to remission: a new paradigm for success in chronic kidney disease

doi.org/10.1016/j.kint.2025.10.004

@georgeinstitute.bsky.social @um-radyfhs.bsky.social
@uhn.ca @utoronto.ca @kidney-resrch-inst.bsky.social @uwnephrology.bsky.social

#OpenAccess #MedSky #NephSky #ckd #gfr

Peripheral blood smear as a diagnostic clue to type I cryoglobulinemia

doi.org/10.1016/j.kint.2025.05.031

#Cryoglobulinemia should be considered in the differential diagnosis of rapidly progressive renal failure even in the absence of cutaneous manifestations.
#NephSky #MedSky

Dual-Antigen Membranous Nephropathy

doi.org/10.1016/j.kint.2025.10.006

#NephSky #MedSky #membranousnephropathy @mayoclinicpath.bsky.social @arkanalabs.bsky.social @lynncornell.bsky.social @aaronstorey.bsky.social

Mouse Alport podocytes are susceptible to AAV9 transduction in vivo

doi.org/10.1016/j.kint.2025.09.027

#MedSky #NephSky
@jeffminerphd.bsky.social @washunephrology.bsky.social @washumedicine.bsky.social

Preclinical evaluation of antigen-specific B-cell depletion for phospholipase A2 receptor membranous nephropathy with chimeric autoantibody receptor T-cells

doi.org/10.1016/j.kint.2025.09.028

#NephSky #MedSky @columbiauniversity.bsky.social @pennmedicine.bsky.social

Sodium glucose cotransporter 2 inhibition does not improve active lupus nephritis in MRLlpr/lpr mice

doi.org/10.1016/j.kint.2025.09.026

#NephSky #MedSky #lupus #nupusnephritis #kidneydisease
@vhir.bsky.social @lmumuenchen.bsky.social @hjanders.bsky.social @pepasolerr.bsky.social

Single-cell spatial transcriptomics reveal intraglomerular cell activation and ligand-receptor relationships in chronic, active antibody mediated rejection

doi.org/10.1016/j.kint.2025.08.042

#MedSky #NephSky @harvardmed.bsky.social

KI–ISN Early Career Researcher Awards | Celebrating excellence Advance your research career with the KI–ISN Early Career Researcher Awards. Recognizing top early-career authors in nephrology for original work published in Kidney International®

📣Apply now for the KI-ISN Early-Career Research Awards
Winners receive:
👏Recognition at WCN 2026
💲500 award

Eligibility
🌟EC researchers (< 7️⃣ yrs post-MD/PhD or post-nephrology/transplant fellowship)
🌟1st authors of an eligible KI article

📆Deadline: 5Dec2025
Details at tinyurl.com/hk6s3s3r

Mini Review
Optimizing symptom management in people with kidney failure

doi.org/10.1016/j.kint.2025.07.040

#KIReview #hemodialysis #NephSky #MedSky #kidneyfailure @sydney.edu.au

Help shape the future of kidney research as the next Editor-in-Chief of Kidney International®.

📅 Deadline: November 3, 2025
➡️ Apply here: http://lite.spr.ly/6... and take the lead in advancing kidney research worldwide.

@kidneyint.bsky.social

Advances in computational #nephropathology

doi.org/10.1016/j.kint.2025.06.029

#OpenAccess #NephSky #MedSky #kidneybiopsy #PathSky
@rbuelow.bsky.social @rwth.bsky.social

🌟Find more articles in our Review Series: Big Science, AI, and Machine Learning:
www.kidney-international.org/content/bigs...

Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function

doi.org/10.1016/j.kint.2025.08.0

#OpenAccess #MedSky #NephSky #kidneydisease #GWAS @uniklinik-fr.bsky.social @columbiakidney.bsky.social @columbiauniversity.bsky.social @kirylukk.bsky.social

A giant leap

doi.org/10.1016/j.kint.2025.07.004

#KIEditorial:SpecialReport #NephSky #MedSky #ckd #chronickidneydisease #PedsNeph

Executive summary of the #KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (#IgAN) and Immunoglobulin A Vasculitis (#IgAV)

doi.org/10.1016/j.kint.2025.04.003

#OpenAccess #MedSky #NephSky @kdigo.org

A randomized controlled trial evaluated the effect of pravastatin on kidney disease outcomes in adult patients with early-stage #autosomaldominantpolycystickidneydisease

doi.org/10.1016/j.kint.2025.08.037

@childrensphila.bsky.social @unmhsc.bsky.social @cumedicalschool.bsky.social #MedSky #NephSky

Commentary
Where next for potassium binders in hemodialysis?
KS Ravi and FR McCausland
doi.org/10.1016/j.kint.2025.07.018

Original article doi.org/10.1016/j.kint.2025.06.016

#MedSky #NephSky #CKD #chronickidneydisease #hemodialysis #cardiovasculardisease #CVD

Inactivation of Pkd2 in adult mice results in delayed cyst formation and identifies sex as a major modifier of disease severity.

doi.org/10.1016/j.kint.2025.08.039

#OpenAccess #NephSky #MedSky #ADPKD #ESKD

Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic #MPGN and #C3glomerulopathy

doi.org/10.1016/j.kint.2025.08.035

#MedSky #NephSky #OpenAccess #kidneydisease

Redefining #kidney failure: broadening metrics to realize equity in kidney care

doi.org/10.1016/j.kint.2025.07.009

Original article: doi.org/10.1016/j.kint.2025.06.015

#KICommentary
#NephSky #MedSky #eGFR #kidneyreplacementtherapy

Fragmented futures: ROCK1 drives mitochondrial fission and muscle loss in CKD

doi.org/10.1016/j.kint.2025.07.012

Original article: doi.org/10.1016/j.kint.2025.05.019

#KICommentary #MedSky #NephSky #CKD #chronickidneydisease

Unfolding the potential—chemical chaperones in #Alportsyndrome

doi.org/10.1016/j.kint.2025.07.006

Original article: doi.org/10.1016/j.kint.2025.05.016

#KICommentary #NephSky #MedSky #CKD

Hypertriglyceridemia causing dialysis filter lipid deposition

doi.org/10.1016/j.kint.2025.04.035

#OpenAccess #NephSky #MedSky #aki #dialysis #crrt #hemodialysis