Zoë A.P. Williams

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis - Nature Medicine Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.

Several years before onset of symptoms of multiple sclerosis, there is evidence of central nervous system myelin injury
nature.com/articles/s41...

Thanks Kristin!! 😊

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

www.nature.com/articles/s41...

Thanks so much Friederike 🥰

Honoured to have been awarded best poster at the @apcmicrobiomeirel.bsky.social symposium !!

A big thank you to everyone who stopped by for the fascinating conversations, and to the organizers for putting together a wonderful day of science❤️

Paternal exercise confers endurance capacity to offspring through sperm microRNAs Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic health via sperm microRNAs that reprogram gene expression in early embryos, revealing how exercise benefits c...

Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...

New landscape of the diagnosis of Alzheimer's disease Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individu...

New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com

#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence

Thanks Kristin!!

Grateful for the opportunity to present my research at the UCC College of Medicine and Health Research Day, and honoured to have received a reward for my talk!!

A huge thanks to the organizers for making this day possible 🌟 It’s always inspiring to see the incredible research being done @ucc.ie

*cracks knuckles*

okay so you know how the media has a problem with taking snippets of scientific studies out of context and writing articles which mislead the public?

now imagine a computer program is doing that when you ask it questions about scientific literature but also it makes stuff up.

⚛️🧪 folks--how do you keep your directories organized and uncluttered? I've got a billion papers I want to read/reference, too many project directories in a few different places (GH repos and stashes Documents folder), and old versions of other people's codes I need, which all needs reorganizing...

A key thing worth knowing about the AI super intelligence claims is that scientists who study cognition are clear we don’t even have a model of human intelligence, so how can you look at an AI and say it’s the same or better? We confuse lots of metaphors for cognition with knowing how it happens.

Figure 1 Astrocyte Cholesterol Efflux to CSF Remains Similar in AD and Control Groups, whereas CSF HDL-like-mediated Cholesterol Delivery to Neurons is Impaired in AD.

Altered Cholesterol Uptake by Neurons in Alzheimer’s Disease Linked to APOE4 Variant www.recercasantpau.cat/en/now/alter... by @irsantpau.bsky.social

#Alzheimers #dementia #health #science #neuroscience

Identification of medication–microbiome interactions that affect gut infection - Nature An analysis of prescription medications shows that several non-antibiotic drugs, such as the heart medication digoxin, can reduce the immune response to pathogens and increase the risk of gastrointest...

Interesting paper from the Goodman Lab:

Identification of medication–microbiome interactions that affect gut infection www.nature.com/articles/s41...

4 pathways

Mental health: Psychiatric conditions leading to cognitive decline

Encephalopathy: Brain dysfunction conditions that escalate over time

Mild cognitive impairment: Gradual cognitive decline progression

Vascular disease: Cardiovascular conditions that contribute to dementia risk

Exciting Senior Scientist 👩‍🔬 👨‍🔬 role available in my research group 🧠 🦠 - Closing date Tuesday 5th August 2025.

Please Share

@apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social
Full details here
my.corehr.com/pls/uccrecru...

{tinytable} is a dead simple, ultra-flexible, and dependency-free #Rstats 📦 to turn data frames into beautiful tables: html, word, pdf, latex, typst, markdown, etc.

v0.10.0 has cool new features and important bug fixes. Check out the detailed tutorials at:

vincentarelbundock.github.io/tinytable/

Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms? - npj Biofilms and Microbiomes npj Biofilms and Microbiomes - Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

Proud to share my new review from my MSCA-INSPIRE @inspiremsca.bsky.social

"Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?"

www.nature.com/articles/s41...

@jfcryan.bsky.social
@apcmicrobiomeirel.bsky.social
@ucc.ie

Comprehensive evaluation of plasma tau biomarkers for detecting and monitoring Alzheimer’s disease in a multicenter and multiethnic aging population - Nature Aging Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese...

p-tau217, the breakthrough blood biomarker for Alzheimer's, picks up risk the earliest and its performance surpasses all other tau biomarkers, across ancestries
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...

This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Why do some people who have mutations of familial Alzheimer's not get the disease?
They have protective genomic variants.
A first-rate review
@thelancetneuro.bsky.social
thelancet.com/journals/lan...

Metformin boosts mitochondria and neurogenesis via AMPK/mTOR/SIRT3 in POLG mutant organoids https://www.biorxiv.org/content/10.1101/2025.06.08.658480v1

📣 Happy to share our review on host-microbiome genomics!

We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes

Out now in Nature Reviews Genetics👇

www.nature.com/articles/s41...

Increased CSF drainage by non-invasive manipulation of cervical lymphatics - Nature The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.

We rely on deep sleep to clear the brain's metabolic waste products (that can induce inflammation), which decreases with aging.
Now there's a discovery of a non-invasive way method to augment waste clearance in aged mice @nature.com
www.nature.com/articles/s41...

The gutting of US biomedical research with loss of ~2,500 grants affecting research for cancer, Alzheimer’s, infectious disease, global health and much more
www.nytimes.com/interactive/...

Inkscape plugin to rescale figures without distorting the text, and other useful features!
github.com/burghoff/Sci...

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....

There's a lot happening for predicting and preventing Alzheimer's disease. Here's the latest.
erictopol.substack.com/p/predicting...