Jacqueline Kimmey

🧪

Respiratory immunization using antibiotic-inactivated Bordetella pertussis confers T cell-mediated protection against nasal infection in mice - Nature Microbiology In this preclinical study, the authors find that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against lung and nasal infection with Bordetella pertussis.

A preclinical study in Nature Microbiology shows that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against whooping cough. #medsky 🧪

Still time to apply to work on #symbioses #mosses #cyanobacteria! Join us in #Copenhagen! @voltcenter.bsky.social

I have been meaning to share this so thank you Ákos for beating me to it! Very proud of the hard work from grad students Devons Mo and Catherine Palmer - they really did a deep dive into Salmonella, Listeria and Pneumo pathogenesis! Enjoy!

“The loss to state economies would be about 40% greater than the federal savings, as losses ripple through state and local economies. In other words, for every $1 the federal government saves, state and local economies would lose $1.40.”

mediarelations.gwu.edu/new-research...

A global perspective on autoinducer-2-mediated cell communication in prokaryotes Biological sciences; Molecular biology; Microbiology

A global perspective on autoinducer-2-mediated cell communication in prokaryotes

- in @cp-iscience.bsky.social

www.cell.com/iscience/ful...

Subcommittee Markup of the Commerce, Justice, Science, and Related Agencies Appropriations Act | United States Senate Committee on Appropriations United States Senate Committee on Appropriations

🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding.

Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.

See 7:15 below. Full Senate appropriations committee meets tomorrow about it.

🧵 1/3

My quote of the day

Refusal to believe until proof is given is a rational position; denial of all outside of our own limited experience is absurd.

Annie Besant

New @neal-lab.bsky.social team photo! ❤️ Leaning on each other more than ever during these times & grateful for this resilient, inspiring group. #NealLab

Dendritic cells activate pyroptosis and effector-triggered apoptosis to restrict Legionella infection | mBio The innate immune system senses bacterial pathogens by employing pattern recognition receptors that detect pathogen-associated molecular patterns (PAMPs) and guard proteins that monitor pathogen disru...

Thrilled that our latest paper showing that DCs undergo either pyroptosis or apoptosis upon bacterial blockade of host translation to restrict Legionella is now online at the @asm.org journal mBio! Congrats to 1st author @vvazquez.bsky.social & co-authors! 🎉 journals.asm.org/doi/10.1128/...

Wondering if your grant will be reinstated from Monday's ruling? Check here.

Plaintiffs have uploaded a list of 848 (of the ~2400 total terminated) they say are covered because they're to institutions in the states aforementioned or a part of APHA/UAW.

The judge must approve the list first.

Love this!!!!

Congratulations!!!!

How Trump Blew Up Northwestern’s Business Model The federal government froze the university’s research funding. It hasn’t offered the school a way to get it back.

The Trump administration froze Northwestern’s research funding. It hasn’t offered the school a way to get it back.

Multi-omics profiling reveals atypical sugar utilization and identifies a key membrane composition regulator in Streptococcus pneumoniae The human body comprises many different microenvironments, each with their own challenges for microorganisms to overcome in order to survive, and possibly cause infection. The human pathogen Streptoco...

Some positive news in troubled times: New preprint by Vincent de Bakker, Xue Liu @jonbakerlab.bsky.social Infection-mimicking conditions+transcriptomics/proteomics/'essentialomics'/lipidomics shows many cool things!
www.biorxiv.org/content/10.1...

2030STEM in partnership with Burroughs Wellcome Fund (BWF) is building a new, catalytic resource to advance the careers of early to mid-career STEM researchers and professionals who are motivated to build an inclusive STEM ecosystem.
Get more informarion at 2030stem.org/fellowship-1

1,600 names needed toward the next 12,800 target. Support NIH and research

So sorry to hear this :(

An experimental test of the effects of redacting grant applicant identifiers on peer review outcomes Redaction, intended to obscure personal and institutional identity, reduced the gap between Black vs. White applicants in simulated review of real NIH scientific grant applications, thus providing qua...

Reminder for when we talk about improving NIH grant review. Huberman brought blind review up with Bhattacharya.

“redaction caused applications from White scientists to score worse” elifesciences.org/articles/71368

New opportunity to help sustain global health research

re-fund-global-health.vercel.app

🚨Incredible opportunity alert!! 🚨
#microbiology

RFK Jr. ousts entire CDC vaccine advisory committee Health Secretary Robert F. Kennedy Jr. has removed every member of a scientific committee that advises the Centers for Disease Control and Prevention on how to use vaccines.

RFK Jr.‘s extreme anti-vax views — and his related conflicts of interest — were a huge problem during his confirmation process.

So he promised not to change the vaccine advisory panel.

Today, he fired every single expert on that panel. It's a public health disaster.

Kennedy Removes All C.D.C. Vaccine Panel Experts

This is on all the Senators who turned a blind eye and voted to confirm. www.nytimes.com/2025/06/09/h...

TBC this freezing of reimbursements to some institutions, like Northwestern, have not been accompanied by ANY terms or requests.

They are simply holding this funding hostage illegally

🤔

New NIH Notice rescinding the no DEI, no Israeli boycott term and condition added to NIH grants (covers the whole university)

This is what Williams refused to sign and declined all federal funding.

grants.nih.gov/grants/guide...

1/2

Two line graphs show NIH Outlays for Grants at Brown University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays around $15,000,000 from October 2024 to March 2025, then drops sharply to $0 in April 2025 and remains at $0 for May and June. Lines for previous fiscal years remain above $10,000,000 throughout the period. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 10% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years remain below 20%.

Two line graphs show NIH Outlays for Grants at Columbia University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays between $40,000,000 and $60,000,000 from October 2024 to March 2025, then drops sharply to approximately $20,000,000 in April 2025 and to $0 in May and June. Lines for previous fiscal years fluctuate but remain generally above $25,000,000. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 20% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years remain mostly below 20%.

Two line graphs show NIH Outlays for Grants at Cornell University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays between $10,000,000 and $20,000,000 from October 2024 to March 2025, then drops to $0 in April 2025 and remains at $0 for May and June. Lines for previous fiscal years show some variability but generally stay above $0, with some dips. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 20% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years show more variability than Harvard and Northwestern, with some spikes, as well, but returning to normal levels after.

Two line graphs show NIH Outlays for Grants at Northwestern University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays around $30,000,000 from October 2024 to March 2025, then drops sharply to $0 in April 2025 and remains at $0 for May and June. Lines for previous fiscal years remain above $25,000,000 throughout the period. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 15% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years remain below 20%.

NEW at grant-watch.us: Emma Mairson and Marian Jarlenski report on funding freezes at Brown, Columbia, Cornell, and Northwestern, that have received zero payments for #NIH grants since the start of April: grant-watch.us/posts/trends...

Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.

Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.

Department of Defense Security for the Protection of Department of Homeland Security Functions MEMORANDUM FOR THE SECRETARY OF DEFENSE                THE ATTORNEY GENERAL

There is no bigger story right now than the White House asserting that California residents are in a state "of rebellion against the authority of the Government of the United States."

In addition to supporting the lab overall, open projects / valuable skills include
1) Natural Products / chemical fractionation
2) Circadian biology
3) Cell signaling / MAPK / translational regulation
4) Zebrafish models - microscopy, genetics etc
#srbr #zebrafish #microbiology #circadian