Ali Darwish, MD, FACP

📊 New study suggests GLP-1 receptor agonists may reduce overall cancer risk in people with obesity #GLP1 #Obesity #Oncology #medsky

🤔 Do you think it’s the weight loss, another mechanism of the drug, or a combination driving this effect?

www.jwatch.org/na59176/2025...

Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction This study evaluates the effectiveness and safety of semaglutide and tirzepatide in patients with cardiometabolic heart failure with preserved ejection fraction in clinical practice.

New JAMA study: Semaglutide and tirzepatide reduce risk of heart failure hospitalization or death by >40% in patients with obesity-related HFpEF and type 2 diabetes—no meaningful difference between the two drugs.

jamanetwork.com/journals/jam...

#health #medicine #MedEd #MedTwitter #CardioTwitter

Crystal waters, stunning views! Lake Como is pure magic. #LakeComo #ItalyTravel #ScenicBeauty #LakesideVibes #TravelItaly #NatureLovers #italia

Six Books That Shaped My Journey: Lessons in Grit, Giving, and Moving Forward Connecting the Dots Between Ancient Stoicism, Modern Science, and the Path to Healing Others

Six Books That Shaped My Journey: Lessons in Grit, Giving, and Moving Forward

Check out: open.substack.com/pub/globalro...
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#LifeLessons #lifestyle #giving #motivation #meditations #Philosophy #medicine #MedEd #MedTwitter #CardioTwitter #BooksWorthReading

The brain’s map of the body is surprisingly stable — even after a limb is lost Study challenges the textbook idea that the brain region that processes body sensations reorganizes itself after limb amputation.

A brain-imaging study of people with amputated arms has upended a long-standing belief

go.nature.com/3Jp9NPG

Finding Peace in the Storm: How Mindfulness-Based Stress Reduction Can Transform Your Daily Life A science-backed approach to managing life's inevitable stresses

🧘‍♀️ Feeling overwhelmed by daily stress? MBSR (Mindfulness-Based Stress Reduction) is a science-backed 8-week program that teaches you to respond rather than react.

open.substack.com/pub/globalro...

#MBSR #Mindfulness #StressReduction #MentalHealth #Wellness #Meditation #StressManagement

OpenAI's Sam Altman sees AI bubble forming as industry spending surges OpenAI CEO Sam Altman thinks the artificial intelligence market is in a bubble, similar to the dotcom bubble, he recently told reporters.

Sam Altman says we're in an AI bubble but that "smart people get overexcited about a kernel of truth." www.cnbc.com/2025/08/18/o...

Market correction incoming or just honest assessment?

#AI #OpenAI #TechBubble #SamAltman

Reprogramming Antibiotics: How AI is Outsmarting Superbugs The AI Breakthrough That Could End Drug-Resistant Infections

AI designed 2 novel antibiotics atom-by-atom to kill drug-resistant gonorrhoea & MRSA! Could this spark a #SecondGoldenAge in antibiotic discovery? How soon will AI revolutionize medicine on a global scale? 🤖💊

open.substack.com/pub/globalro...

#Superbugs #AntibioticResistance #AIinMedicine

Apple’s Next Big Bet: An AI Robot for Your Living Room Apple’s smart home is about to get a personality

Apple’s smart-home future looks straight out of Pixar: think an iPad on an animating arm that dances, follows, and converses. How will you feel when your tech starts acting—and feeling—human?

open.substack.com/pub/globalro...

#SmartHome #AI #Apple #Robotics #Siri #HomeTech #artificialintelligence

Claude for Education could change how kids learn — instant feedback, deeper dives, & curiosity over memorization

But here’s the question: if AI becomes a learning co-pilot, will kids still learn to think on their own? Or will not using it be a disadvantage?

#AIinEducation #FutureOfLearning #EdTech

Global Rounds with Ali Darwish | Substack Physician. Dad. Traveler. Photographer. Global Rounds is my take on the world — in images, stories, and ideas worth sharing. Click to read Global Rounds with Ali Darwish, a Substack publication. Launc...

I just started a Substack: Global Rounds with Ali Darwish globalrounds.substack.com?r=26r0iz&utm...
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#lifestyle #travel #health #photography #health #medicine #MedEd #MedTwitter #CardioTwitter #medicaleducation

Apple Executives Have Held Internal Talks About Buying AI Startup Perplexity Apple Inc. executives have held internal discussions about potentially bidding for artificial intelligence startup Perplexity AI, seeking to address the need for more AI talent and technology.

What are your thoughts on this? I can see the logic with an Apple - Perplexity Deal.
www.bloomberg.com/news/article... #ai #artificialintelligence #apple #perplexityai

One potent gene raises risk of Alzheimer’s, Parkinson’s and other brain diseases Massive proteomics database links gene variant APOE4 to chronic inflammation.

A gene variant known to increase the risk of Alzheimer’s disease also makes people vulnerable to a host of other age-related brain disorders

go.nature.com/4eRJcGD

Eighteen million years of diverse enamel proteomes from the East African Rift - Nature The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteomic and evolutionary studies.

Nature research paper: Eighteen million years of diverse enamel proteomes from the East African Rift

go.nature.com/44JrujP

New: PURSUIT, a novel, once-daily oral molecule inhibitor, showed robust, dose-dependent effects on LDL-C and favorable safety in patients with hypercholesterolemia on moderate- or high-intensity statin treatment. bit.ly/3XG7Oe2 #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

Christoph, good question. The @accintouch.bsky.social graphic states one may be more likely to have a high LP(a) if one also has an LDL >190 or familial hypercholesterolemia. Not a direct causation.

1 in 5 adults have an Lp(a) level that is too high. Check out the infographic to learn more. bit.ly/3RxBF4F

#health #medicine #MedEd #MedSky #CardioSky #medicaleducation

Cannabis Use Substantially Increases Risk of Heart Attack - American College of Cardiology

New Study: Cannabis Use Substantially Increases Risk of Heart Attack
📌 MI: Sixfold 🔺
📌 Ischemic Stroke: Fourfold 🔺
📌 Heart Failure: Twofold 🔺

www.acc.org/Latest-in-Ca...

#health #medicine #MedEd #MedSky #CardioSky #medicaleducation

The 2024 Clinical Practice Guideline focuses on the evaluation and management of Chronic Kidney Disease (CKD), emphasizing early detection and comprehensive management strategies. #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

New Pill Successfully Lowers Lp(a) Levels Muvalaplin shows promise in lowering lipoprotein(a) levels, which are genetically determined and confer cardiovascular risk and for which no approved therapies currently exist.

Muvalaplin safely lowers high levels of lipoprotein(a), or Lp(a), results from the phase 2 KRAKEN trial show. www.medscape.com/viewarticle/... #MedEd #MedSky #CardioSky

New Study: LAA Closure post-ablation led to:
⬇️ major bleeding vs. OAC (8.5% vs. 18.1%)
Noninferior for stroke, systemic embolism & death
www.nejm.org/doi/abs/10.1... #health #medicine #MedEd #MedSky #CardioSky

New 2025 US guidelines for managing ACS (STEMI and NSTE-ACS) recommend intravascular imaging with OCT or IVUS during PCI for left main or complex lesions with a class IA recommendation #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

10 Simple Ways to Transform Your Workday and Boost Productivity Ten Easy Ways to Change Your Workday and Increase Productivity In the fast-paced workplace of today, increasing productivity is crucial for…

10 simple yet powerful strategies to transform your workday and boost productivity, including morning routines, task prioritization, and minimizing distractions. #productivity #worklife #GTD

The New England Journal of Medicine Catheter Ablation for Ventricular Tachycardia A Research Summary based on Sapp JL et al. | 10.1056/NEJMoa2409501 | Published on November 16, 2024 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

Among patients with ventricular tachycardia and ischemic cardiomyopathy, catheter ablation as an initial therapy led to a lower risk of adverse outcomes than antiarrhythmic drug therapy. Full VANISH2 trial results and Research Summary: nej.md/3Z5ECOD

#MedSky #CardioSky

New BMJ guideline finds little to no benefit but potential harms for common spine injections. Recommends against most interventional procedures for chronic non-cancer spine pain. https://buff.ly/4i71SCm #health #medicine #MedEd #MedSky #CardioSky

New AHA/ACC guidelines on competitive sports for athletes with heart conditions emphasize shared decision-making, updated sports classifications, and addressing racial disparities in screening. https://buff.ly/433gDSu #health #medicine #MedEd #MedSky #CardioSky

Standardized Definitions of Changes in Kidney Function in Trials of Heart Failure https://buff.ly/4k8hmrF #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

Targeted Ganglionated Plexi Ablation With Nanoformulated Calcium Suppresses Postoperative AF Via Vagosympatholytic and Anti-Inflammatory Effects https://buff.ly/433s8cW #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

New AI models can help keep clinical guidelines up-to-date by continuously analyzing real-world data, say researchers. This could provide "hyperlocalized, up-to-date recommendations" for medical decision-making. #MedEd #MedSky #CardioSky https://buff.ly/4hZBPgt

Microplastics accumulate in the brain, 7-30x more than other organs. Levels much higher in those w/ dementia. Linked to blood clots and impaired brain blood flow. #microplastics #MedSky #CardioSky https://buff.ly/4aYwIes