Jibran Khokhar

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

A short Bluetorial on plots of NIH application success rates as a function of percentile.

1/20

How Congress can restore the independence of US science Members must go beyond reinstating US government research spending and re-establish decentralized governance at the National Institutes of Health and other agencies.

The most impt change at #NIH and to US science this year is bigger than grant cancellations— it’s how the agency is governed.

For 75 years NIH has been largely independent of presidential control. That’s changed this year. New piece from me and @nataliebaviles.bsky.social in @nature.com
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Check out our new paper, and join this webinar where @drjkhokhar.bsky.social and I will discuss the science and more!

www.eneuro.org/content/13/2...

Toronto unhurried. 6 am at NPS.

As good an image as any to illustrate America’s contribution to Middle East peace, order, and stability over the last 30 years.

www.amazon.com/gp/aw/d/B0FW...

U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office A Science analysis reveals how many were fired, retired, or quit across 14 agencies

The U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office.

A Science analysis reveals how many were fired, retired, or quit across 14 agencies. Read more: https://scim.ag/4boPkq8

Longer dive into the data, meaning, and consequences

substack.com/home/post/p-...

International Women's Day 2026 Nature highlights developments in women’s health research and career guidance for women in science.

International Women’s Day celebrates the Earth’s 4 billion female inhabitants. Nature brings you a collection of the latest on advancements in women’s health and career guidance, advice and inspiration for women in science. 🧪 #IWD2026

GluN2D NMDARs: Bridging Physiology and Pathology NMDA receptors are pivotal mediators of excitatory neurotransmission and play crucial roles in normal brain development, synaptic plasticity, and higher-order cognitive functions such as learning and…

This review examines the GluN2D subunit of NMDA receptors, detailing its developmentally regulated, cell-type specific expression in interneurons, its role in excitatory-inhibitory balance, and its growing significance in neuropsychiatric and neurological disorders.

History and Medicine - Associate Professor or Professor with Tenure - McMaster University This role is designed for an exceptional scholar whose work bridges humanities-based historical inquiry and contemporary infectious diseases scholarship, with particular emphasis on the history of pla...

Cool opportunity to work at the intersections of climate/environmental history and history of medicine!

History and Medicine – Associate Professor or Professor with Tenure – McMaster University

Apply by March 31st

niche-canada.org/2026/03/05/h...

#envhist #histmed #climhist #cdnhist

This is what a fake war of liberation looks like: dark, gloomy, suffocating.

www.lemonde.fr/en/middle-ea...

Visual P300 and risk for psychosis onset in youth at clinical high-risk Current clinical criteria are not sufficiently predictive of psychosis onset to inform treatment decision-making among individuals at clinical high risk for psychosis (CHR). Identifying biomarkers…

Visual target P300 amplitude deficits are associated with earlier psychosis conversion in clinical high-risk individuals, demonstrating promise as a biomarker for psychosis onset.

A single dose of DMT reverses depression-like symptoms in mice by repairing brain circuitry A recent study in Translational Psychiatry shows that one dose of DMT reversed loss of pleasure and cognitive deficits in stressed mice. The psychedelic promoted new brain cell growth, highlighting its potential as a rapid-acting antidepressant.

A single dose of DMT reverses depression-like symptoms in mice by repairing brain circuitry

It's morning in Tehran, but the sun cannot get through because the city is covered in black smoke from the oil refinieries/reserves targeted by IDF-US forces. The sun is blocked by Oil! Beyond the immediate consequences, this is accelerating the pathway towards a burning planet that is uninhabitable

The scenes out of Tehran are horrifying.

What absolute madness.

One must assume that anyone who expresses surprise or "shock" that the IDF-US coalition is systematically attacking civilian infrastructure critical for life and is repeatedly commiting actions that kill civilians must have been living under a rock for the past 3 years.

Scientists warn fake research is spreading faster than real science A sweeping new study from Northwestern University reveals that scientific fraud is no longer just the work of a few rogue researchers—it has evolved into a global, organized enterprise. By analyzing m...

“fraudulent studies are now appearing at a faster rate than legitimate scientific publications. The authors say the findings should serve as a warning to the scientific community to strengthen safeguards before public trust in science begins to erode”
🧪 #Scicomm
www.sciencedaily.com/releases/202...

'Semaglutide induced comparable reductions in BW & food intake in both sexes but elicited distinct sex-specific changes in body composition. Male mice exhibited losses in both skeletal muscle and organ mass, whereas female mice preferentially lost fat and organ mass while preserving skeletal muscle'

For those keeping track, we’re at the “secretary of war announces genocide” stage of the US descent into fascism.

That column on the far right is the death of American biomedical science.

Iran’s people were facing a horrible shortage of water before the war began. If we are destroying desalination plants and setting fire to Teheran we are committing unfathomable crimes.

“A country that has been subject to a bombing campaign does not emerge as a liberal democracy. It emerges traumatized, fragmented, furious.”

New paper inspired by @nanopharmnc.bsky.social
Xylazine's k-opioid agonist activity is not shared with other FDA-approved alpha2-adrenergic agonists

www.biorxiv.org/content/10.6...

Always awesome to work with you and your team Bryan!

Superpowers for Claude Code: Complete Guide 2026 Discover Superpowers, the official Claude Code plugin that implements TDD, parallel sub-agents, and professional workflows. Complete guide with real examples and best practices.

If you are using Claude Code you should definitely check out the superpowers tool - it greatly streamlines the process of planning and development. www.pasqualepillitteri.it/en/news/215/...

Looking to improve your PeerReview skills? The Reviewer Mentor Program pairs trainees with #JNeurosci & #eNeuro editors & top reviewers to conduct strong manuscript reviews. Open to SfN members at any career stage: http://www.jneurosci.org/rmp

FORM | Wellcome Leap: Unconventional Projects. Funded at Scale. NEW $50M Program Foundations of a Resilient Microbiome APPLY NOW We are pleased to announce the selected performers.Kiran Raosaheb Patil, University of CambridgeLaurel...

Predictably enough, one of the people funded by Wellcome LEAP's FORM project is James B. Adams brainfoundation.org/brain-invest..., whose work featured in our recent review www.cell.com/neuron/fullt..., and not in a good way.
see wellcomeleap.org/form/

A screenshot of the article title: Reframing oxytocin as a behavioral flexibility hormone

Scientific claims in biobehavioral oxytocin research are dependent on a “derivation chain”. Theoretical models are the beginning of this chain, which are dependent on a theoretical core supported by auxiliary hypotheses. Efforts to improve biobehavioral oxytocin research have tended to focus on auxiliary hypotheses related to experimental models (e.g., improving oxytocin delivery to the brain, polygenic approaches for genetics studies), and statistical auxiliary hypothesis (e.g., appropriate sample sizes for research). However, even if these issues are addressed, a poorly specified theoretical core (and associated auxiliary hypothesis) can lead to unreliable scientific claims

Oxytocin is typically described as a "social" hormone. In our new article, we propose that it should instead be viewed a hormone that modulates behavioral flexibility

doi.org/10.1016/j.ne...

Hoping as many American professors, researchers, trainees & technicians as possible attend the #StandUpForScience rallies across the US tomorrow. It’s an important message to send to Washington, but the rest of the world is also watching & supporting you in taking a stand on attacks on science. 🫡

We trust you had a great time joining our webinar.

Thank you for being there, and see you again next month.

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