Dr Laura McCulloch

Understanding pneumonia vulnerability in stroke recovery at University of Edinburgh on FindAPhD.com PhD Project - Understanding pneumonia vulnerability in stroke recovery at University of Edinburgh, listed on FindAPhD.com

We are looking for a PhD. student to work with us on our investigation into immune suppression and infection vulnerability after stroke. This project will focus on the lung immune environment and therapeutic interventions to improve infection clearance.
www.findaphd.com/phds/project...

Join the Dyer Lab (Dr @douglaspdyer.bsky.social) as a Research Associate in Neuro-Immunology & Extracellular Matrix Biology (ImmunoMatrix).

🔬 Focus: chemokines, glycocalyx & inflammatory disease

📍 Cutting-edge biochem, biophysics & in vivo biology

Apply now 👉 shorturl.at/jEQ6G

Research Associate in Mucosal Immunology :Manchester

🚨 The Menon lab is hiring a postdoc!

Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social

Please help spread the word #ImmunoSky

www.jobs.manchester.ac.uk/Job/JobDetai...

Explore new research on #Neuroimmunology & #Neurodegeneration, incl. macular degeneration, the role of #microglia, β-amyloid transport, CNS #autoimmunity, and the sympathetic control of cancer progression 👉 rupress.org/jem/collecti...

#ksneuroimmune25 #ksneurodegen25 @keystonesymposia.bsky.social‬

Please join us for the summer EIG mini symposium on Tuesday 17th of June. The session starts at 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 with talks by Prof Simon Graham, Dr Kate Sutton and Prof Christoph Scheiermann. See you there!

Macrophages direct location-dependent recall of B cell memory to vaccination Subcapsular sinus macrophages in the draining lymph node help retain resident memory B cells in the subcapsular niche and promote their re-entry into secondary germinal centers. Boosting vaccines in the same arm leads to more rapid secretion of broadly neutralizing antibodies.

Now online! Macrophages direct location-dependent recall of B cell memory to vaccination

This was an exciting collaboration in @edinuni-irr.bsky.social driven by Rachel Martin and Isobel Mouat supported by Robert Whelan and @lizihegarty.bsky.social and collaboration with CJ Anderson, David Dockrell, @bainlab.bsky.social and @gwotzerho.bsky.social funded by @wellcometrust.bsky.social

Together these data show dynamic changes to the intestine and intestinal microbiome throughout stroke recovery and gives some insight into which factors may be responsible for prolonged gastrointestinal disturbance after stroke

We also found altered luminal IgG concentrations and reduced antibody coating of intestinal bacteria only at 3 months post stroke.

Changes to the composition of the microbiome were detected througout recovery. Surprisingly these changes were distinct at acute and chronic recovery time points suggesting different driving factors may be associated with these changes.

At our earliest timepoint, 5 days post stroke, there is a reduced mucus barrier in the colon and a delayed intestinal transit time. However these normalise in chronic recovery

We found lower body weights and structural changes to the colon persisted out to 3 months after experimental stroke (MCAO) in mice

🚨New preprint alert 🚨
www.biorxiv.org/content/10.1...

Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke

The spring EIG session is coming this Thursday on 1st of May. Please join us from 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 for fantastic talks by Dr. Elizabeth Mann, Dr. Tovah Shaw and Prof. Hamida Hammad. See you there!

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

The most complete map of a brain is unveiled today - Science Museum Blog Roger Highfield, Science Director, reports on the latest milestone in what is billed as the most complicated neuroscience experiment ever.

blog.sciencemuseum.org.uk/the-most-com...

First map of human brain mitochondria is ‘groundbreaking’ achievement Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

'The results show that mitochondria, which generate the energy that powers cells, differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions.'
www.nature.com/articles/d41...

Heart-brain-spleen axis that induces adaptive cardiac remodeling in response to pressure overload
www.cell.com/immunity/ful...
preview @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Organ-specific sympathetic innervation defines visceral functions - Nature Multi-modal transcriptomic analyses of the sympathetic nervous system reveal organ-specific neural innervation and modular regulation of visceral functions.

Organ-specific sympathetic innervation defines visceral functions

www.nature.com/articles/s41...

Stoler-Barak, @zivshulman.bsky.social et al. show that SMARCA5-mediated #chromatin remodeling is required for germinal center formation rupress.org/jem/article/...

📘 In Multifaceted B Cell Functions & Dysfunctions: rupress.org/jem/collecti...
#KSBCells25

Our new collection highlights recent advances in B lymphocyte biology from homeostasis to inflammation & dysfunction leading to lymphoma development. Read new research accompanying @keystonesymposia.bsky.social on Multifaceted B Cell Functions & Dysfunctions: https://buff.ly/3CX1Y0O
#KSBCells25

Research Assistant (177885) We are looking for a Research Assistant with a background in immunology/neurobiology to join the interdisciplinary laboratory of Dr Fränze Progatzky at the Kennedy Institute.

🚨 We have TWO exciting open positions in our lab! 🚨

We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as:

🔬 Research Assistant
www.kennedy.ox.ac.uk/jobs/researc...

💻 Bioinformatics Postdoc
www.kennedy.ox.ac.uk/jobs/bioinfo...

📢 Please share!

Frontiers | Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome

Our new publication on BCR sequencing in ME/CFS, adding to the evidence of an increased usage of IGHV3-30.

Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease.

www.frontiersin.org/journals/imm...

Sorry to hear that, but I'm happy you've had a good recovery

First Post on blue-sky. We are hiring! Post-doctoral position available in the neuroimmunology of stroke. Please check out link below and share elxw.fa.em3.oraclecloud.com/hcmUI/Candid...