bioRxiv Molecular Biology

Drug-bound P-glycoprotein reveals nucleotide-dependent ligand pockets and ingress channels https://www.biorxiv.org/content/10.64898/2025.12.04.692475v1

Predicting and Designing Red Fluorescent Protein Variants Using Sequence-to-Function Machine Learning Models https://www.biorxiv.org/content/10.64898/2025.12.05.690496v1

Structure of human lymphoid-specific helicase HELLS in its autoinhibitory state https://www.biorxiv.org/content/10.64898/2025.12.06.692698v1

High-resolution insights into the geographic differentiation and hybridisation of Odontobutis gobies through integrated eDNA and SNP analyses https://www.biorxiv.org/content/10.64898/2025.12.05.692706v1

Expanding the Genome in a Bottle Truth Set: Detection and Validation of Novel Low-frequency Variants Using High-accuracy NanoSeq https://www.biorxiv.org/content/10.64898/2025.12.05.692678v1

CYB5R3 Controls Sex-Specific Stress Erythropoiesis via Heme-Biosynthesis https://www.biorxiv.org/content/10.64898/2025.12.04.692104v1

Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery https://www.biorxiv.org/content/10.64898/2025.12.04.692291v1

The development and validation of long-read ITS-1/5.8S/ITS-2 nemabiome metabarcoding using Oxford Nanopore Technologies (ONT) ... https://www.biorxiv.org/content/10.64898/2025.12.04.692384v1

Praja1 protects cells from DNA damage through direct DNA binding https://www.biorxiv.org/content/10.64898/2025.12.04.691747v1

KCNQ1 regulates human neuronal development through mitochondrial and insulin signalling pathways https://www.biorxiv.org/content/10.64898/2025.12.04.692265v1

Nucleoside-Modified mRNA Encoding Alpha-Galactosidase A Reverses Fabry Disease Phenotypes in Human IPSC-Derived Cardiomyocytes https://www.biorxiv.org/content/10.64898/2025.12.03.692072v1

Tex15 is required for vomeronasal sensory neuron diversity and male pheromone detection https://www.biorxiv.org/content/10.64898/2025.12.03.690614v1

Scalable insect cell expression and purification screening applied to CRL4-DCAF substrate receptors https://www.biorxiv.org/content/10.64898/2025.12.04.690205v1

miRNA-mediated cell-to-cell communications boost DNA repair during theRadioadaptative Response https://www.biorxiv.org/content/10.64898/2025.12.03.692007v1

End-to-end single-stranded DNA sequence design with all-atom structure reconstruction https://www.biorxiv.org/content/10.64898/2025.12.05.692525v1

The first poly(A) polymerase from Alphaproteobacteria https://www.biorxiv.org/content/10.64898/2025.12.04.692054v1

Reprogramming the Rossmann Fold Signature Motif Creates Orthogonal Redox Biocatalysts https://www.biorxiv.org/content/10.64898/2025.12.03.692188v1

Amplification-Free Dual-Blocking Autocatalytic CRISPR-Cascade for Atto-Molar DNA Detection with Low Nonspecific Signal https://www.biorxiv.org/content/10.64898/2025.12.03.692097v1

Human RNase 2 is essential for macrophage response to viral RNA https://www.biorxiv.org/content/10.64898/2025.12.03.691791v1

TGF-β signaling regulates the response of the skeleton to phosphate https://www.biorxiv.org/content/10.64898/2025.12.01.691659v1

Tiarins, a diverse family of natural Trojan-horse aminoacyl-tRNA synthetase inhibitors discovered by genome mining https://www.biorxiv.org/content/10.64898/2025.12.02.691738v1

Mapping the latent CRBN-molecular glue degrader interactome https://www.biorxiv.org/content/10.64898/2025.12.02.691773v1

Proximity of pre-mRNA 3' end processing and transcription termination predicts enhanced gene expression https://www.biorxiv.org/content/10.64898/2025.12.02.691783v1

Development and structure-guided characterization of a novel ACE2-binding macrocyclic peptide https://www.biorxiv.org/content/10.64898/2025.12.01.690145v1

Improved cloning-free one-step CRISPR-Cas12a-assisted tagging of mammalian genes using PCR generated reagents (PCR tagging) https://www.biorxiv.org/content/10.64898/2025.12.02.690677v1

Plant parasitic cyst nematodes respond to viral infection through RNA interference https://www.biorxiv.org/content/10.64898/2025.12.02.691819v1

Halves and fragments derived of tRNAs in Escherichia coli are selectively associated with 30S ribosomal subunits and in the cytosol https://www.biorxiv.org/content/10.64898/2025.12.02.691187v1

Extended nuclear glycosylation is a common post-translational modification https://www.biorxiv.org/content/10.64898/2025.12.02.691741v1

FET proteins and PARylation-dependent condensates promote replication fork reversal and genome stability https://www.biorxiv.org/content/10.64898/2025.12.01.691651v1

{Phi}X174 bacteriophage viability predicted by protein biophysical modeling https://www.biorxiv.org/content/10.64898/2025.12.01.691700v1