Wyoming Wormboy

So I’d imagine that I’m not the only one looking into switching my (low level) paid account from open.ai to Anthropic. Any thoughts about which performs better for your average academic scientist?

Surprising partner preference found in matings between Neanderthals and modern humans Male Neanderthals tended to pair up with female modern humans, but whether intercourse was consensual is unclear

Although “preference” might not be the most accurate word choice, an interesting finding.

Try living here!

Registration is OPEN for the 2026 Santa Cruz Meeting on Developmental Biology!!! #scdb26

@flybase.bsky.social @zfinmod.bsky.social @alliancegenome.bsky.social @insdb.bsky.social @isdb.bsky.social @geneticssociety.bsky.social @bsdb.bsky.social @ascbiology.bsky.social

scdb2026.sites.ucsc.edu

Are you interested in Comparative Developmental Biology? Great opportunity for grad students and Postdocs to take this 2 week course at the MBL in October 2026.

Homeostatic maturation programs drive human cDC2s into a tolerogenic state @cp-immunity.bsky.social
www.cell.com/immunity/ful...

The 3 hardest things to learn as a scientist:
1. Trust the data.. especially when it’s not what you expected,
2. Trust the data.. allowing it to change your direction,
3. Trust the data.. but not too much: test with new data at every turn.

Hey now, they didn’t say the review will be fair.

Vaccine Makers Curtail Research and Cut Jobs

Life saving medicines with a positive economic impact for the US. Completely nuts.

Here's another paper in our ongoing collaboration with Greg Odorizzi's lab at CU-Boulder:

AP-3 and the V-ATPase Modulate CTP Synthase Assembly Through Spatial Association at the Yeast Vacuole

www.biorxiv.org/content/10.6...

I was diagnosed with locally advanced colon cancer at age 46, one small step from metastatic cancer. At the time, screening started at age 50 and I had no known family history.

Colon cancer (and other cancers) are increasingly common at younger ages. Get checked out. Get more time.

PIKI-1, a class II PI 3-kinase, functions in endocytic trafficking Author summary The uptake of materials from outside the cell and their subsequent delivery to specific intracellular locations are essential for cell function and survival. Two of the mechanisms that ...

Our uncorrected spoof, I mean proof! More forays into lipids and sensors and the intricacies of membrane trafficking. Thanks again to three reviewers for authentically helping us make this a better manuscript. Peer review is essential.
dx.plos.org/10.1371/jour...

Exactly.👍

There is no right answer for everyone. Generally wait until the the department has ranked candidates. If you’re #1 and invited to a 2nd visit, bring it up before the visit so they can set up some meetings and start working towards an accommodation. But if vibe is No Chance, consider just passing.

Advice for a friend: When one gets a tenure track offer, at what stage would be best to bring up a possible spousal hire in negotiations? At first conversation? After first offer? In this case it'll be first a conversation with the chair who is a go-between w/ the dean. Advice would be welcome.

🎉 LEE LAB PAPER ANNOUNCEMENT for this month's issue of #GENETICS! We're celebrating from both coasts, bc after defending her MS in 2024, Deepshi's now a biotech researcher in the Bay Area.

tl;dr: nucleosome remodeling is necessary to repair germline DNA damage 🧬
academic.oup.com/genetics/art...

Sadly I’ve heard of Kid Rock and even more sadly I’ve heard Kid Rock (not in person).

One thing to add is that all the sledgehammers in the world won’t save you from a bad plan. So, think things through carefully!
Also, science can be surprising and is unpredictable, so you also need to NOTICE THINGS while you’re doing the experiment and not ignore red flags. These are the keys.

I would like to think @wyomingwormboy.bsky.social for describing the Sledgehammer Approach (to research) in WormBook. It is invaluable advice that I share with every trainee.

Thank you Joe!

Haha!

I was feeling somewhat guilty about saying No to many recent requests but then I re-read the “children’s book”, The Giving Tree. Felt better.

Apparently some people interpret the tree’s hyper accommodating behavior as a positive example! I’m pretty sure that was not the author’s intention!

Please stop saying the bill allows "no more multi-year funding" - or at least be clear the 'more' is in reference to disastrous FY25 levels.

The bill allows 39% MYF, same as in FY25, which contributed substantially to a 24% drop in new research.

The bill has some wins. MYF is not one of them.

For the same reason that Indiana, which is virtually the same size as Massachusetts received nearly $349 million last year in farm subsidies, while Massachusetts got only about $9 million, 1/39th of Indiana’s boon.

Excited to see this out in the world. The CGC is launching a curated strains collection, the first being protein degradation systems and this is a pilot primer to pair with it authored by myself, Dave Reiner, Ann Rougvie, and Aric Daul. We review the state of the field and provide use guidance (1)

I have an answer. He’s just another self promoting D-bag who traded in legit credentials for cash.

One reason to have kids is that they sometimes do clever things. (Note the signs on the side of the trail)

Absolutely essential

DeGette Introduces Bill to Protect NIH From Political Interference

bit.ly/4qBQEuz
@degette.house.gov

snow on branches ❄️