Denis Jabaudon

Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT

neuro-unige.ch/news/csf-mee...

Co-lead by @nataliabaumann.bsky.social and Ilaria Morassut with Sabine Fièvre as senior author.

Cell-extrinsic controls over neocortical neuron fate and diversity Cell-extrinsic cues are key for neocortical cell identity and diversity.

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

"You cannot not communicate". Paul Watzlawick.

Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.

Dear Reviewer #2, thank you for accepting to assess our revisions. After 60 days, the editor gave up, you never answered. The 1st author worked day & night to address your points, but you were too busy to even say no. The outcome is irrelevant, his disillusion isn't.

Review responsibly, it matters.

Postdoc opportunity in the heart of Europe! Check out the flyer below.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development - Nature Neuroscience The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism in the ChP that modulates ...

Brilliant @natneuro.nature.com by @scienceyael.bsky.social
@lehtinenlab.bsky.social, uncovering “a fundamental secretory pathway in the
Choroid Plexus that shapes brain development” in mice 🧪🧠
www.nature.com/articles/s41...

Still openings, check it out!

Illustration showing a graduation ceremony, with speaker addressing graduates: “Let the example of my fluke success guide nearly all of you to crushing disappointment”.

Success in academia often has more to do with luck, patronage and the job market than “hard work”.
Good academics acknowledge this.
I worked hard, but I was in the right place at the right time on occasion. Historians far more talented than I have fallen between the cracks.

"One day, when it's safe, when there's no personal downside to calling a thing what it is, when it's too late to hold anyone accountable, everyone will have always been against this." - Omar El Akkad

Thanks; we only have access to the VZ progenitors in the transcriptomics analysis, and many cerebellar neurons are born from abventricular progenitors. In VZ progen, Fam210b is only rostral.

🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.

This is a result of a long & intense effort by many folks in the lab, spearheaded throughout the years by @nataliabaumann.bsky.social, with strong contributions by R.Wagener and A.Javed. Great collab. with the @harschnitz.bsky.social lab too, as well as with other partners. Hope you enjoy it!

Hence, cellular clocks tick at different paces across brain regions due to distinct metabolic properties of progenitors. This work thus adds to research on metabolism setting cellular timing across species, by showing these differences regulate brain shape within species too!

Using in vivo gain- and loss- of function of FAM210B in the hindbrain and neocortex, respectively, we find that FAM210B elongates mitochondria and increases
lactate production, which promotes progenitor self-replicative divisions and, ultimately, a larger clonal size of their progeny.

Using scRNA sequencing of all ventricular progenitors, we found genes with spatially and temporally restricted expression (baumannn.shinyapps.io/Ventriculome). Amongst these, the mitochondrial protein Fam210b was expressed where and when cell-cycle is the longest.

When we examined regional cell-cycling behavior of progenitors, we found less consumptive divisions in cortical progenitors compared to hindbrain ones, resulting in a sustained availability of the progenitor pool in the cortex. Mitochondrial morphology was different across regions too!

Using this atlas, we find that while both forebrain and hindbrain regions are born early, only in the forebrain – and particularly in the cortex – is there a prolonged time window of neurogenesis. Some regions thus show transient neurogenesis, while in others it is sustained.

As a first step to address this question, we built a spatio-temporal atlas of neuronal birth across brain structures, available at neurobirth.org (use your PC to navigate), building on Altman and Bayer’s seminal work on brain development (www.neurondevelopment.org).

Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...

Shared Neural Codes for Emotion Recognition in Emoji and Human Faces Facial expressions are critical social signals, essential for human communication. This study used EEG to investigate the neural dynamics of the processing of emotional expressions in real and emoji faces, using a data-driven approach. Across two experiments with identical paradigms, two separate sets of participants viewed facial expressions (happy, angry, sad, neutral) in real faces (4 female and 4 male identities, n = 24) or emojis (6 platforms, n = 25) while performing a two-alternative forced-choice emotion recognition task. Time-resolved multivariate classification and spatio-temporal searchlight analyses revealed robust decoding of emotional expressions within and across experiments. Consistent effects emerged early and peaked between 145-160 ms over posterior-occipital and parietal regions. Notably, robust cross-classification between real and emoji faces demonstrated that face-like emoji stimuli evoke neural responses comparable to those elicited by real faces, with more sustained effects over right posterior sites. These findings suggest that the brain uses overlapping spatio-temporal codes for naturalistic and symbolic facial expressions, providing new insights into the neural coding of social signals and the representational overlap between natural and artificial emotional expressions. ### Competing Interest Statement The authors have declared no competing interest.

😯

doi.org/10.1101/2025...

#Standupforscience event today at Campus Biotech in Geneva. In solidarity for our colleagues in the US and in support of universal values of science: transparency, evidence, cooperation, and intellectual honesty.

Open positions in human developmental neuroscience, check it out!

Open positions in neuroimmunology in Paris, check it out!

Atypical functional connectome in congenitally blind humans The cortex is organized along macroscale structural and functional gradients that extend from unimodal to transmodal association areas and from somatosensory to visual regions. It has not been tested ...

Atypical functional connectome in congenitally blind humans
doi.org/10.1101/2025...

Interesting study on cell-type-specific aging using single-nuclei transcriptomics in the human neocortex. Not clear to me based on this graph that pace of aging is striking different across cell types.
doi.org/10.1101/2025...
see also
https://doi.org:10.1038/s41593-024-01742-z

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus.
doi.org/10.1101/2024...

A bit of a spooky title, but nice ressource for longitudinal imaging of brain connectivity throughout life.

Functional Hierarchy of the Human Neocortex from Cradle to Grave doi.org/10.1101/2024...

Long-term in vivo imaging of single neurons in the developing mouse brain from early postnatal days on. A game-changer in figuring out developmental trajectories. From the Cossart lab.
doi.org/10.1101/2025...

Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins Proper brain function requires the precise assembly of neural circuits during development. Despite the identification of many cell-surface proteins (CSPs) that help guide axons to their targets, it re...

In drosophila, by manipulating sets of surface proteins, you can re-engineer connectivity of olfactory neurons and generate a new neuron type that alters courtship behavior. Impressive work from the Luo lab.
doi.org/10.1101/2025...