Kei Sakamoto

The structure of BAY-3827 with wild-type AMPK α2 kinase domain by @zeqiraj.bsky.social & postdoc Mohd. Syed Ayengar helped determine the mechanism of action of this compound and the limitations for its use, addressing a long-standing challenge in the field: the absence of specific AMPK inhibitors.

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....

Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...

The gut hormone mimetic era in medicine is just getting started
www.nature.com/articles/s42...
erictopol.substack.com/p/the-gut-br...

Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks. www.nature.com/articles/s42...

Happy to have contributed to this very interesting work ked/driven by Raid Nisr, Alison McNeilly and Graham Rena (University of Dundee). doi.org/10.1111/apha...

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

The surprising result for a GLP-1 pill (orforglipron) is the magnitude of weight loss in a Phase 3 trial of participants with Type 2 diabetes. For still unexplained reasons, people with diabetes lose much less weight on GLP-1 drugs than those with obesity, w/o diabetes.

Th most-cited research papers of all time. A 1951 publication by US biochemist Oliver Lowry in the Journal of Biological Chemistry describing an assay to determine the amount of protein in a solution has been cited more than 350,000 times.

Eli Lilly announced positive results from a large clinical trial of its once-daily pill orforglipron in people with type 2 diabetes, while Pfizer announced last week it was halting development of its candidate after signs of liver injury in a trial participant.

Joan was a visionary and inspirational leader, researcher and generous mentor and friend. His legacy will stay forever.
@irbbarcelona.org

Trump’s new CDC pick ‘has her work cut out for her’ Susan Monarez, an expert in biosecurity and infectious disease, strikes some as a sensible choice to head the health agency—but some staffers there have raised concerns

President Donald Trump has nominated Susan Monarez, an infectious disease researcher and current acting director of the Centers for Disease Control and Prevention, to become the agency’s permanent leader. scim.ag/425J0xs

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

Interested in aging?

Super excited about this upcoming Keystone meeting!! 🧪🌲🌲
Aging: Immune Function and Organ Health -- Banff, Canada in 2026!!! ✨✨

Joint meeting with the Keystone Innate Immunity meeting!

#aging #immunity @keystonesymposia.bsky.social

www.keystonesymposia.org/conferences/...

The Strategic Research Programme in Diabetes at Karolinska Institutet and Umeå Univeristy is seeking a Programme Manager (based in Stockholm).

More information about the programme is here ki.se/en/srp-diabe...

and the link to the position is here ki.varbi.com/en/what:job/...

Please repost!

Thank you very much for this initiative and providing us with the opportunity to share our memories and stories. His legacy will stay forever. Visionary and inspirational leader, researcher and generous mentor and friend.

Many congrats Elton. Hope our manuscript is the next success!!

More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...

Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as a future foundational therapy for people with overweight and obesity Company announcement – No. 4 / 2025 Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as...

A partner for Petrelintide #obesity www.globenewswire.com/news-release...

"Glycogen drives tumour initiation and progression in lung adenocarcinoma"

Strong presence of the @labsakamoto.bsky.social group members at the Metabolism Day #MD25 @cbmr.science Posters were presented by postdocs Joy & Jordana and by PhD students Maria, Hongling, Conchita & Costanza. #AMPK #TFEB #SIK

Science Advances’ special issue on women’s health highlights a growing wave of research focusing on women’s unique biological and psychological experiences. Articles cover a range of studies from the interplay between menopause and Alzheimer’s risk to the menstrual cycle’s influence on the brain-heart connection. It also describes the opportunities pregnancy provides to research aspects of both physical and mental health. By prioritizing women’s unique physiological and psychological experiences, research can expand the frontiers of knowledge in ways that benefit everyone.

A special issue on #WomensHealth in #ScienceAdvances highlights a growing wave of research focusing on women’s unique biological and psychological experiences.

Learn more: scim.ag/3R59fPe (THREAD 🧵)

Our group @cbmr.science is now driven by an all women workforce (barring Kei), & we are incredibly fortunate to have these (multi)talented, hard working & generous women who support & elevate each other every day!
Happy International Women's Day!
#WomensDay2025 #LatePost

NIH will eliminate many peer review panels and lay off some scientists overseeing them

Currently, NIH's Center for Scientific Review reviews 66,000 grant applications a year, with panels run by NIH’s separate institutes reviewing the rest.

Under a new plan, the institute-run panels will be eliminated, and many of the scientists overseeing them will be laid off. scim.ag/3QP0FUG

As women in academia, having children can feel impossible. Talking about it makes us feel less alone The struggle is “balancing their careers not just with motherhood, but with what comes before: relationships and planning for a family,” these postdocs write

"The academic structure … makes planning for a family feel like an impossible luxury."

In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/3F60VMt #InternationalWomensDay

Hope you just us next time:)

Pleased to share our new preprint describing mechanistic insights and cellular selectivity of the AMPK inhibitor.

Just created my account today:)

Thanks Pablo for promoting our preprint manuscript! You are faster then us...!

Large-Scale Protein Production and Activity Assay Protocols for Human Glycogen Synthase-Glycogenin Complex Glycogen synthase (GS) is the rate-limiting enzyme for glycogen production and together with glycogenin (GN) and glycogen branching enzyme (GBE), can generate glycogen particles containing up to 50,00...

Out now: Our method article describing large scale production & enzyme activity measurements of human glycogen synthase-glycogenin (GS-GN) complex published in the MIMB book series. Lead by researcher, Dipsikha Biswas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social