Joseph Castellano

NOT TO MISS | A SPECIAL #BrainAwarenessWeek EVENT! 🧠 On Friday, March 27, 10am, JOIN Dr. @jmcastell.bsky.social
when he hosts @stanfordneuro.bsky.social's Dr. Tony Wyss-Coray at this special #BrainBodyResearchInstitute Seminar Series Lecture. Register Now 👉 mountsinai.zoom.us/webinar/regi...

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

Thanks, Silvia!

Thanks, Sandro - hope you're well!

Overall, our work supports that TIMP2 (and likely other unexplored youth-associated factors) could be important for reducing microglial dysfunction in age-related disorders. Thanks for reading! (end).

TIMP2 ⬇️ microglial activation, ⬆️ phagocytosis, and ⬇️ the proportion of microglia associated with deleterious processes, including pro-inflammatory processes and senescence—essentially reversal of several age-associated microglial phenotypes. (5/n)

Since key changes in microglia are seen regardless of which TIMP2 pool is targeted, we wondered if ⬆️the extracellular pool mitigates age-related microglial changes. Since TIMP2 gets into brain f/ blood, we gave aged mice systemic TIMP2 injections. (4/n)

TIMP2 deficiency ⬆️microgliosis, ⬇️phagocytosis, and induces transcriptomic changes associated w/ activation + cytokine production. Hippocampal microdialysis revealed that TIMP2 loss ⬆️cellular stress and inflamm. proteins in the extracellular space. (3/n)

We prev. found that TIMP2 regulates hippocampal plasticity. Since microglia regulate plasticity, we looked at how differing TIMP2 sources affect microglial state and function by targeting global, neuronal, and microglial contributions to the TIMP2 pool. (2/n)

Youth-associated protein TIMP2 alters microglial state and function in the context of aging There is little understanding of how aging serves as the strongest risk factor for several neurogenerative diseases. Specific neural cell types, such as microglia, undergo age-related maladaptive chan...

Excited to share a new preprint out from the lab (www.biorxiv.org/content/10.1...) by 1st-author Brittany Hemmer, a newly minted PhD from the lab! A brief thread on what we found (1/n):

Special thanks to her fantastic committee, incl. her committee chair Anne Schaefer (pictured), @scottrussophd.bsky.social , @mcalpinelab.bsky.social , and @cheadlelab.bsky.social for invaluable guidance. She's seeking postdoc opps. in the Boston area (incl. NH/RI)—reach out if interested!

🎉Thrilled to announce that my awesome PhD student, @brittany_hemmer , successfully defended her thesis! Her thesis work is now preprinted (brief summary to follow)—proud of her hard work and perseverance!

Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social!

Registration 🔗 us02web.zoom.us/meeting/regi...

#NewVisionResearch #ProfessionalDevelopment

Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting. Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.

Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration

Fantastic talks at #CCAD2025 Reunion Conference! @sinaibrain.bsky.social @jmcastell.bsky.social, Panos Roussos and Kuan-Lin Huang

Congrats, Nick!

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...

Our latest in PNAS! 🎉

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep

Take home message?

KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.

www.pnas.org/doi/10.1073/...

Congrats to you and the whole team!! 👏🍾

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

Fantastic study - congrats!!!

Neuroscience methods - YouTube Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!

Please like and repost to help us get the word out!

www.youtube.com/playlist?lis...

Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵

Atlas of the plasma proteome in health and disease in 53,026 adults. #Cell #medBsky #SciBsky #scisky #proteome

These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com).

Open Access
www.cell.com/cell/fulltex...

Great pack - can you please add me?

Updated Aging Starter Pack!! People and labs interested in aging 😀 Let me know if you'd like to be added!

go.bsky.app/5UXXaDA

I'd love to be added - thanks for organizing the list!

Thx - good to see you here!

I'd love to join!

Thanks - much appreciated!

Blueksy shaped butterfly with appearance of neural connections throughout

Hello Bluesky! 🦋 I’m an Associate Professor of #Neuroscience at the Icahn School of Medicine at Mount Sinai. I study how memories are stably stored and flexibly updated across time and experience 🧠 I also develop open-source tech!
Looking forward to connecting here! #Neuroskyence #WomenInSTEM