Josh Koenig

It was wonderful to share the lab’s work with colleagues at McMaster University and their Immunology Research Center. Thanks, Amy and Josh, and lovely to meet colleagues at my Alma mater. #LZCI

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1

Thank you Arthur!

Absolutely!

Thank you Mariya!

Notice of Decision from CIHR. Decision: Approved.

What a great thing to wake up to! Thank you CIHR for the support for the lab to dive into the mechanisms of immune memory in allergy!

Check out the latest publication by @khoulahan.bsky.social!

Have you listened to the Hadestown tiny desk? It's so great!

Mutability and hypermutation antagonize immunoglobulin codon optimality McGrath et al. investigate the evolutionary relationship between V(D)J mutability, somatic hypermutation, and codon optimality within immunoglobulin repertoires in order to gain a better understanding of how diversification mechanisms might impact antibody expression efficiency.

Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell! @cellpress.bsky.social
www.cell.com/molecular-ce...

would be curious about #hemesky's input here- any concern about inducing hypercoagulability through vaccine adjuvantation with thrombopoeitin (TPO)?

Awesome study that also highlights species-specific differences in immunity (e.g. plasma cell APRIL dependence) and the consistency across...

It's surprisingly accurate too!

Mutability and hypermutation antagonize immunoglobulin codon optimality The efficacy of antibody responses is inherently linked to paratope diversity, as generated through V(D)J recombination and somatic hypermutation. Des…

Really interesting study on the mutability and codon optimality of human IgV genes, showing an inverse relation. Mutability appears to trump codon optimality for immunoglobulin genes! www.sciencedirect.com/science/arti... 🩸🔬 #b-cells #immunology

A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.

So proud @theonlylabever.bsky.social who persevered with this impactful project. First author Dr. Kyle Burrows is now lunching his own lab at SFU. Nicely done!

That is gorgeous! Well done.

#LocationLocationLocation! Burrows, Mortha &co show @cellcellpress.bsky.social that a gut commensal protozoan induces ILC2 migration from the gut to the lung & interaction with T & B cells, recruiting lung eosinophils that shield the vasculature aggravating #asthma but protecting from #Mycobacterium

Architecture of the high-affinity immunoglobulin E receptor Structural analysis reveals species-specific differences in how the antibody IgE binds to its receptor FcεRI.

Amazing new paper providing the architecture of the high-affinity IgE receptor in a IgE-sensitized state and the apo state. Also revealing that mice and men are different...
#Immunosky #Immunology
www.science.org/doi/epdf/10....

The total mass, number, and distribution of immune cells in the human body | PNAS The immune system is a complex network of cells with critical functions in health and disease. However, a comprehensive census of the cells compris...

B CELL FUN FACT: Secrets of the GC #2

There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! Naïve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!

www.pnas.org/doi/10.1073/...

Very excited to share the most recent work from #theonlylabever out in @jexpmed.bsky.social

We show that a gut protozoan commensal acts as a natural adjuvant for IgA against oral and bacterial antigens to strengthen homeostasis.

Hope you will find this interesting:
doi.org/10.1084/jem....

🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov

Just signed up, please add me in :)

Keystone Symposia conference in 2026 for B cells and plasma cells, in Keystone Colorado

Save the date! It may be a while to go yet, but I’m very excited for our B-cellapalooza in 2026!

Production and use of antigen tetramers to study antigen-specific B cells - Nature Protocols Antigen-specific B cells constitute a small proportion of the total B cell population, making identification for downstream analysis challenging. Here, this is achieved by pairing fluorescent antigen ...

Thanks to Josh Koenig, Allyssa Phelps, & Diego Pazos-Castro for taking the lead and writing up the protocol below initially developed during the early days of my postdoc. Discussed in this go.nature.com/3OxA5yD “behind the paper” post. www.nature.com/articles/s41...