sbrimble.bsky.social

That we are it seems. We are considering developing an optimal start indicator that would look at % of patients in a program starting as an outpatient, maybe “deferred” based on starting eGFR, and on their preferred modality. Probably vascular access agnostic.

Thoughts?

Bring them to Antiques Roadshow

Swap, do you think it’s all just about the 24-hr BP AUC above (and perhaps below) an optimal BP? When I get to a 3rd drug I do like to have one of them in the evening and assume the overall BP control is better but do worry about adherence.

Always respect those who put in the effort to conduct a well thought RCT. Very few of our patients choose CAPD these days. Also, If I’m reading the baseline eGFR correctly, “less dialysis” for most of the patients could have been no dialysis?

The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol - Michael Walsh, David Collister, Martin Gallagher, Patr... Background: The mineralocorticoid aldosterone may contribute to the risk of cardiovascular morbidity and mortality in patients receiving maintenance dialysis. W...

It's been a long journey but today we can share the methods and rationale for the #ACHIEVEtrial (Spiro vs placebo for patients with kidney failure receiving maintenance dialysis) and tomorrow we share the results at #era25
journals.sagepub.com/doi/10.1177/...

Bring back reserpine…

Eww…mushy chips…

Anemia guidelines flagrantly ignoring RCT evidence

As an example

Guidelines hijacked by industry for decades

The 2006 KDOQI adequacy guideline that told us to start looking for any indication to start dialysis when eGFR drops below 15 (and in some cases even earlier) has always been seared into my brain as a particularly bad recommendation.

Maybe we should put together a consensus conference or controversies in guidelines meeting in Fiji to really hash this out.

God I could not disagree more, at least with the sentiment/rationale provided (see below). Might as well have entitled it “Make American Nephrology Great Again”. I should add that is even though I have issues with how heavily industry-conflicted KDIGO can be.

some of the most striking tortured phrases i’ve seen in a while. Look here to discover what “moo warm steadiness” is
pubpeer.com/publications...

I also wonder when chlorthalidone is back, how many patients will end up being on 2 thiazides for a time.

Has to be the most heavily advertised movie in years. Makes me think they’re worried it’s going to be a flop.

I guess you can’t pass it over.

I finally got it. #NephMadness. Madness….its not supposed to make any sense.

So basically you decide who would win and decided to put yourself second so as not to draw suspicion. Got it…

FFS…JNC 8…?!

a lot of people think you need a lot of money to buy clothes. now you're right. ok. my bad.

a man is holding a shirt that says well that 's absolutely not true on it ALT: a man is holding a shirt that says well that 's absolutely not true on it

And no traffic…

Aww a little snow on April 7th doesn’t sound like fun?

Presumably all-cause mortality. Trial could be stopped after the interim analysis by week 4.

It’s the Police, man. And I’m old. Old enough to remember this movie…

THIS IS WHAT A TRADE WAR LOOKS LIKE -

If you are a US size 12 I can sell you my old 2014 pair…

YouTube video by francis bacon Dusty Springfield - I Don't Think We Could Ever Be Friends 1982

I think it was Sting with Jean Roussel (I hear a drum kit and no guitar). Dusty Springfield also did the song the following year www.youtube.com/watch?v=Mksp...

Little known fact, Christos is only 26 years old #kalopenia

Yep, said as much. But ACHIEVE (clinicaltrials.gov/study/NCT030...) is recruiting 2500 dialysis patients; outcome is CV death or HF hospitalization. I seriously doubt any intervention short of transplant could be shown to reduce all-cause mortality in this pop’n with a sample size of 1K.

Fair enough. Any good info on environmental impact eg 💦?