Lawrence Chun Man Lau

CRISPR helps to show why a boy felt no pain Mutation in an enzyme leads to resistance to chronic and acute pain, according to research in mice.

The study of a boy who was unable to feel pain could lead to innovative therapies for chronic pain

https://go.nature.com/4kfFnN7

Alignment of the femur and tibia before and after personalization. This figure presents how the Torsion Tool changes the shape and alignment of the femur and tibia (red) compared to the generic torsion model (green). The left side represents the personalization for the femoral torsion model, while the right side represents the personalization for the torsion-informed model. The personalized models represent one participant with a 36° femoral version and 38° tibial torsion.

What is the impact of femoral and tibial torsion on patellofemoral loading in individuals with patellofemoral instability? Find out in this recent paper by Bernhard Guggenberger & coauthors: onlinelibrary.wiley.com/doi/10.1002/...

🚨 Call for Articles Due May 31! The @jorthopres.bsky.social is accepting submissions for a special issue on 𝘾𝙪𝙧𝙧𝙚𝙣𝙩 𝙏𝙤𝙥𝙞𝙘𝙨 𝙞𝙣 𝙊𝙧𝙩𝙝𝙤𝙥𝙖𝙚𝙙𝙞𝙘 𝙄𝙢𝙥𝙡𝙖𝙣𝙩 𝙏𝙚𝙘𝙝𝙣𝙤𝙡𝙤𝙜𝙮. Contribute to a key resource for researchers. Submit here: mc.manuscriptcentral.com/jores

How Patients' Lifestyle Affects the Wear of Hip Implants? This In-Silico Study @JOrthoPres.bsky.social suggests current ISO standards conditions notably tend to underestimate volumetric wear by up to 60% compared to the simulated patient types. Link: buff.ly/TQZQxkJ
@orssociety.bsky.social #ORSSMC

HappyDerbyDay! #ORSxDerby #KyDerby
Equine acute synovitis model? In @JOrthoPres.bsky.social this model show Liraglutide's anti-inflammatory effect by reducing CCL2 concentrations in whole blood, PBMCs, chondrocytes, and synoviocytes
buff.ly/0OAY8EH
@orssociety.bsky.social #ORSSMC

Happy to share this! This study provides evidence of excellent long-term survival (>=20 years) of cementless components without screw holes with immediate postoperative weightbearing allowed. Link: buff.ly/EF4L4aw
#THA #TotalHipArthroplasty #HipReplacement #APHS @BoneJointOpen

This study used caliberated CT to show that bone density changes across the innominate bone due to age and sex tend to vary between individuals, although consistent effects were seen at specific regions. buff.ly/j2Uhe4J
@orssociety.bsky.social #ORSSMC #ORSxDerby #KyDerby #BMD #fracture

Meet Dr. Dianne Little, DVM, PhD, a vet surgeon & orthopaedic scientist leveraging multi-omics to advance rotator cuff tendon tissue engineering. Her translational work advocates for more inclusive approaches in regenerative medicine. 👩‍🔬
buff.ly/3mrzXoF
#ORSxDerby #ORSSMC
@ORSsociety.bsky.social

LinkedIn This link will take you to a page that’s not on LinkedIn

Great interview with Prof. Mandi Lopez, Professor of Veterinary Surgery in LSU School of Veterinary Medicine ! She shares her career, interests, and life advice for the orthopaedic research community! Check it out here: buff.ly/I8VdeCt
@orssociety.bsky.social #ORSSMC #ORSxDerby #KyDerby

study @JOrthoPres.bsky.social showed radiographic OA severity was the best predictor of preoperative biomechanical function, but postoperative function was best predicted by preoperative muscle fat-fraction.
#ORSSMC @Orthopaedic Research Society @orssociety.bsky.social

Link: buff.ly/WNLXyfg

@orssociety.bsky.social‬

@JOrthoPres.bsky.social

study @JOrthopRes showed intra-articular administration of diclofenac etalhyaluronate as a conservative treatment option for advanced and end-stage hip osteoarthritis, particularly for patients unsuitable for surgery or poor tolerability to oral form.
#ORSSMC @ORSsociety

Link: buff.ly/bljRHgw

Journal of Orthopaedic Research | LinkedIn Journal of Orthopaedic Research | 288 followers on LinkedIn. The Journal of Orthopaedic Research is a publication of the Orthopaedic Research Society (ORS). | The Journal of Orthopaedic Research, a publication...

interesting study buff.ly/AMw0vk5 found human OA synovial fluid affects the electrochemical behavior of CoCrMo and varied on a patient-by-patient basis, possibly some implication on TKA?
hashtag#ORSSMC Orthopaedic Research Society buff.ly/g9pExbT
Link: buff.ly/6sRh2SP

recent study @Journal of Orthopaedic Research by Pierce develop a YOLOv8-based deep learning model to automate the detection, segmentation, and quantification of cartilage microcracks from Second harmonic generation images #ORSSMC #ORS @Orthopaedic Research Society link: buff.ly/5ZB8JBa

New weapon ? recent study in @JOR buff.ly/4dMOYVq by Trenkwalder found membrane filtration of sonication fluid (MF) has been shown to be a useful method for identifying septic nonunion. #ORSSMC #ORS buff.ly/rH02cn9
Link:https://buff.ly/LU4pij3

Compression Neuropathy affect bone? Recent research in Journal of Orthopaedic Research @JOrthopRes found no sig differences in BMD, biomechanical properties, or key bone signaling proteins between the affected and control tibias

hashtag#ORSSMC Orthopaedic Research Society

Link: buff.ly/1opJ7qX

Recent findings in @JOrthopRes showed vertebral bone strength is affected not only by sex and bone mineral density but also by degenerative changes. Thus, bone strength could be predicted more accurately in patients with spinal disease using FEA. hashtag#ORSSMC
doi.org/10.1002/jor....