Repeter wants an Ukr victory

GFI1 Inhibition as an Approach to Reduce T Cell Exhaustion When continually stimulated, as occurs in persistent viral infections and cancer, T cells of the adaptive immune system become exhausted. This state is characterized by an inability to attack and kill pathogens and harmful cells. As with any other aspect of the immune system, however, exhaustion is not a well-defined and simple binary state, but...

GFI1 Inhibition as an Approach to Reduce T Cell Exhaustion https://www.fightaging.org/archives/2025/08/gfi1-inhibition-as-an-approach-to-reduce-t-cell-exhaustion/

#biology #medicine

excited

excited https://theycantalk.com/post/791541436479832064/excited

OK, yes, ok, yes,but.. this is another tack, first off local as default and the other to another way to handle hallucinations.

"It’s always bugged me that we can’t explain how large language models do what they do. It makes the models difficult to trust, possibly unsafe to operate, and very […]

Vi trodde på de svenska reglerna | Dagens Arena Vi har arbetat, betalat skatt, följt lagen och uppfostrat våra barn här.

I Sverige. Massutvisningar enligt retroaktiv lagstiftning av hederligt folk som arbetar, betalar skatt och följer alla lagar och regler. Nej, det är inte enskilda, ömmande fall, det beror inte på dumma byråkrater, är inget förslag, Inte något som befaras ske under nästa mandatperiod. Det sker nu.

I HATE ILLINOIS NAZIS.

#BluesBrothers were ahead of their time. #MovieClips https://getyarn.io/yarn-story/ac8b2567-f65f-47bf-be0f-7a867fb40ddd

OK, this is actually an interesting way of doing testing, regardless of what language you're using (modulus some, I guess..)

My Kind of REPL https://www.reddit.com/r/lisp/comments/1mkn046/my_kind_of_repl/

#programming #lisp

I’m not a Bloomberg subscriber but I get a few of their newsletters. It’s interesting to me that they’re more or less 100% free of MAGA cant. They point out that tariffs are lose/lose, that the climate crisis is real and disastrous, that fucking with vaccines is lethally dangerous, etc etc. All […]

Long Links

Tim Bray's long links are always a treat. Stop by and take a break.

Long Links https://www.tbray.org/ongoing/When/202x/2025/08/04/Long-Links

typical Captcha window with tic box and text: Verify that you're human * I recognize Palestine CEASEFIRE now

Verify that you're human:
#GazaGenocide

Endor: Fire up a Dev Environment in Seconds With WebAssembly Newly launched Endor allows developers to create reproducible, isolated testing environments in a few seconds instead of hours or days.

Endor: Fire up a Dev Environment in Seconds With WebAssembly https://thenewstack.io/endor-fire-up-a-dev-environment-in-seconds-with-webassembly/

Currently only PHP, but soon Node.js and ... lotsa stuff I guess.

#programming #wasm

To people crying socialism, this is not something the government has decided. It's been negotiated between McDonald's Denmark and the workers' union.
To everyone whining abt taxes: In Scandinavia (and the EU), nobody needs to work two or three jobs or > 40 […]

[Original post on mastodon.social]

NPR: Engineer restores pay phones for free public use

"...Schlott has taken old pay phones, modified them to make free calls, and set them up in three different towns across the county. He buys the phones secondhand from sites like eBay and Craigslist and restores them in his home workshop […]

Screenshot from some other social media. Text reads: millenianthemums i want a shirt that has a QR code on it for some kind of horrible malware so that if anyone ever tries to film me in public their phone will automatically scan the code and be reduced to a functionless brick iwasrightaboutthesun Modern day Medusa

This. Just, this.

2/2 ...I can’t recommend enough the newsletter “Cold Eye Earth” by Gregor MacDonald. Here are two excellent pieces explaining the problem.
“Not Fast Enough” […]

1/2 I think most people who are environment/global-warming focused read and were cheered by Bill McKibben’s New Yorker piece last month: https://www.newyorker.com/news/annals-of-a-warming-planet/46-billion-years-on-the-sun-is-having-a-moment

Me too! And I guess this means that fossil fuel […]

It's finally here!

Ghost 6.0 is the biggest update we've ever made — and it includes federated publishing for everyone, with ActivityPub ❤️

We also shipped a brand new native analytics sweet, and passed a pretty cool milestone. Independent publishers […]

[Original post on activitypub.ghost.org]

Watching "The Big OOPs", new 1h50m talk by Casey Muratori about the mistakes & shortcomings of OOP and better/alternative ways forward...

https://www.youtube.com/watch?v=wo84LFzx5nI

(Also very interesting for some #PermaComputing & KISS aspects)

#SoftwareArchitecture #ECS #DOD

New horror movie about to drop:
"I KNOW WHAT YOU VIBE CODED LAST SUMMER"

"Today’s global civilisation, however, is deeply interconnected and unequal and could lead to the worst societal collapse yet, he says. The threat is from leaders who are “walking versions of the dark triad” – narcissism, psychopathy and Machiavellianism – in a world menaced by the climate […]

🇺🇦 launched a large-scale UAV attack on 🇷🇺 military targets, including the 🇷🇺 radar & sonar State Research Centre Concern Elektropribor in St Petersburg, the automation factory and development centre Radiozavod (Rostec) in #Penza, a #Shahed drone warehouse at Primorsko-Akhtarsk airfield in […]

I was listening to a podcast about food and they said did you know that ‘Parmesan’ powder sold outside the EU is mostly cellulose, as in wood pulp, and I remember how I once tweeted that and everybody was mad at me for being a snob

It's complicated.

Welp, it's official.

I had to let go of a client today because they are *all-in* on the slop machines…Claude to be precise. They intend for it to be integral to all code going forward.

I told them I can't do it. I won't do it!

Which leaves me in a real bind because the one major client I have […]

The article points out that the rise on borrowing and visiting libraries in Denmark is an anomaly in Europe*, which is a pity. It also rightly identified that the number of events, reading groups and a good selection of books are key to get people into libraries. IMHO, the other important factor […]

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