PathologyOutlines.com

Image of the Week!

Contributed by: Dre Barnachea, M.D.
Textbook topic: Skin melanocytic tumor
Diagnosis: Sentinel node biopsy-melanoma
Textbook topic link: www.pathologyoutlines.com/topic/skintu...

#Pathology #PathologyOutlines #PathSky

www.pathologyoutlines.com/topic/stains...

(Image Quiz, continued)

A. C4d0 (extensive positivity in the renal interstitium)
B. C4d0 (marked background staining of collagen)
C. C4d0 (no staining of peritubular capillaries)
D. C4d3 (diffuse positivity in > 50% of peritubular capillaries)

See link in comments.

#Pathology #PathologyOutlines

Image Quiz! A patient underwent renal transplantation 3 weeks earlier, subsequently developed oliguria, and was found to have circulating donor specific antibodies. Kidney biopsy was performed, and immunofluorescence for C4d is shown. What does the image demonstrate?

(Continued in thread)

Dr. Nat Pernick, founder and owner of PathologyOutlines.com, believes businesses should embrace charitable activities as a core part of their mission. One way PathologyOutlines.com puts this commitment into action is through scholarships.

Info: buff.ly/xX7RfUD

#PathologyOutlines #Scholarships

Society of Black Pathology is a nonprofit dedicated to addressing barriers to health equity, decreasing health care disparities, and increasing the number of underrepresented individuals in pathology and laboratory medicine.

Learn more: buff.ly/6rcYNlo

#SocBlackPath #BlackHistoryMonth #Pathology

How can we improve the PathOut site for 2026? Take this survey powered by surveymonkey.com. Create your own surveys for free.

www.surveymonkey.com/r/2026_Site_...

📣 Tell us what you think! Please share feedback about our website via the brief survey linked in the comments.

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Image of the Week!

Contributed by: Serena Ammendola, M.D.
Textbook topic: CNS & pituitary tumors
Diagnosis: Melanoma
Textbook topic link: www.pathologyoutlines.com/topic/cnstum...

#Pathology #PathologyOutlines #PathSky

Will you be at USCAP in San Antonio next month? Visit us at Booth 656, March 23–25, 2026! Dr. Nat Pernick will be at our booth on Monday and Tuesday (23rd–24th).

See what’s in store at our booth: buff.ly/owyLqDY

#USCAP2026 #USCAP #Pathology #PathologyConference #PathologyOutlines #PathSky

www.pathologyoutlines.com/caseofweek/c...

(Case of the Month, Continued)

The patient had ongoing acute gastrointestinal bleeding and evidence of significant coagulopathy. A peripheral blood smear sample was processed shortly after collection and therefore artifact is not expected. What is your diagnosis?

Full case linked in comments!

Case of the Month: A 50 year old man with decompensated hepatic cirrhosis due to alcohol use disorder and hepatorenal syndrome is being evaluated for a possible liver transplant. Pertinent laboratory values are shown on the Case page. (Continued in thread)

#Pathology #PathologyOutlines #Diagnosis

Image of the Week!

Contributed by: Debra L. Zynger, M.D.
Textbook topic: Adrenal gland & paraganglia
Diagnosis: Composite pheochromocytoma and paraganglioma
Textbook topic link: www.pathologyoutlines.com/topic/adrena...

#Pathology #PathologyOutlines #PathSky

www.pathologyoutlines.com/topic/skintu...

(Image Quiz, Continued)

A. Becker nevus
B. Congenital melanocytic nevus
C. Epidermal nevus
D. Nevus spilus
E. Tinea versicolor

Answer linked in the comments.

Image Quiz! A 14 year old boy presents with a unilateral hyperpigmented plaque with irregular borders on the upper chest. The lesion is associated with increased coarse hair growth over the area. What is the most likely diagnosis?

(Continued in thread)

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From margin notes back then to a globally trusted resource today, it’s been an incredible 25-year journey for PathologyOutlines.com.

Explore our interactive timeline to see the milestones that shaped PathologyOutlines.com: buff.ly/sn8E9mh

#Pathology #PathologyOutlines #25thAnniversary #PathSky

Essay: “My Male Breast Cancer, Part 6”, by Dr. Nat Pernick

Part 6 of this series discusses Dr. Pernick’s subsequent drug therapy for male breast cancer.

Access here: buff.ly/gJjbgvc
Follow Curing Cancer Network: buff.ly/npW2JwB

#Cancer #CuringCancerNetwork #Pathology #PathologyOutlines #PathSky

Dr. Pernick started a new textbook on the Curing Cancer Network home page, titled "How Cancer Arises". There may be overlap with PathologyOutlines.com, but this textbook is being developed independently.

Info: buff.ly/9F3uFuM

#CancerResearch #CuringCancerNetwork #Pathology #PathologyOutlines

Image of the Week!

Contributed by: Maria Tretiakova, M.D., Ph.D.
Textbook topic: Prostate gland & seminal vesicles
Diagnosis: Seminal vesicles–adenocarcinoma
Textbook topic link: www.pathologyoutlines.com/topic/prosta...

#Pathology #PathologyOutlines #PathSky

We recently appointed several new editors to our Editorial Board! We welcome Dr. Anna Biernacka, Dr. Ashwini Kumar Esnakula, and Dr. Alexei Mikhailov to the Board.

Read about them here: buff.ly/quZQZ8n
Our Boards: buff.ly/JQSLJQp

#Pathology #Textbook #PathologyOutlines #PathSky

Read the latest Curing Cancer Network newsletter: www.pathologyoutlines.com/ccnnewslette...

Follow CCN on LinkedIn: www.linkedin.com/company/curi...

#Cancer #CancerResearch #CuringCancerNetwork #Pathology #PathSky

Be like Dr. Navarro; send us your favorite PathologyOutlines.com pic! We’d love to see your favorite PathOut moments, like selfies at our conference booth or featuring our merch! Selections to be shared on our social media. Send yours: comments@pathologyoutlines.com

#Pathology #PathologyOutlines

Image of the Week!

Contributed by: R. Peter Powell, M.D.
Textbook topic: Pancreas
Diagnosis: Duodenal neuroendocrine tumor
Textbook topic link: www.pathologyoutlines.com/topic/pancre...

#Pathology #PathologyOutlines #PathSky

www.pathologyoutlines.com/topic/ovaryt...

(Image Quiz, continued)

A. Borderline mucinous tumor of the ovary
B. Borderline mucinous tumor of the ovary with microinvasion
C. Mucinous adenocarcinoma of the ovary
D. Mucinous cystadenoma

Answer linked in the comments.

#Pathology #PathologyOutlines #Diagnosis

Image Quiz!

A 39 year old woman presents to the clinic with a 6 month history of mild abdominal pain and distension. A CT scan of the abdomen shows a 20 cm adnexal mass. The patient undergoes surgery, and the tumor is shown. What is your diagnosis?

(Continued in thread)

Read our latest “What’s New in Pathology” newsletter.

January 2026 Issue: “What’s New in Molecular Genetic Pathology 2026: Emerging Biomarkers for Personalized Cancer Therapies” by Umberto Maccio, M.D., MSc., M.B.A.

Webpage: buff.ly/XAoEkz3
PDF: buff.ly/V4UfVNo

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Throwback Thursday ✨️ What year did you first connect with Dr. Pernick or PathologyOutlines.com at a conference? The first of these photos is from USCAP in 2005, and the others are from various conferences in 2010–2015.

#Pathology #PathologyOutlines #ThrowbackThursday