The Journal of Immunology

Immunology of Zoonotic Diseases and Relevant Animal Models Crystal Loving guest edits a collection of reviews featuring research on diseases that lie at the interface of human and animal health.

#InternationalVeterinaryMedicineDay recognizes the essential role of Vets in global health. Animal models, both traditional and nontraditional, are crucial for studying the complex immunology of diseases that jump species barriers. 📖 Zoonotic Diseases collection: academic.oup.com/jimmunol/pag....

Veterinarian with a dog in front of a globe, celebrating International Veterinary Medicine Day honoring vets and scientists.

Happy #InternationalVeterinaryMedicineDay! See how diverse species are advancing research in our special collection in The Journal of Immunology, "Beyond the Mouse: Nontraditional Animal Models." Discover more: https://ow.ly/i5Vk50XGp5K.

Associated transcription factors of allergic rhinitis: SP1 aggravates nasal epithelial barrier damage Abstract. Allergic rhinitis (AR) is a respiratory airway disorder characterized by inflammation and barrier dysfunction. The transcription factor specifici

Data suggest that transcription factor specificity protein 1 (SP1) aggravates allergic rhinitis through the upregulation of forkhead box C1 (FOXC1), which reverses the protective effect of SP1 silencing on epithelial barrier damage. Read more online: ow.ly/cKOO50XFVik.

MEF2D regulates T-cell function via CD70-CD27 signaling and promotes immune evasion in hepatocellular carcinoma Abstract. Hepatocellular carcinoma (HCC) stands as one of the most prevalent and fatal malignancies globally, posing a persistent challenge in its treatmen

Researchers found that MEF2D blocks T-cell–mediated antitumor immunity by regulating the expression of CD70 and activating the CD70-CD27 signaling axis. Manipulating this pathway may improve the efficacy of liver cancer immunotherapy. Learn more: ow.ly/nh8n50XFUxU.

📥 Submit your abstracts for IMMUNOLOGY2026™ by Dec 16 and ensure that your original abstract is published in The Journal of Immunology as a supplement: immunology2026.aai.org/abstracts/

📖 Explore last year's IMMUNOLOGY2025™ abstracts now: academic.oup.com/jimmunol/iss...

This November #TopRead from Wei Luo and Shlomchik Lab demonstrated that PTEN deficiency selectively expanded germinal center B cells in Peyer’s patches but had no impact on those induced by immunization, revealing an unknown role for PTEN. Read more: ow.ly/Ia9k50XAbiP.

Volume 214 Issue 11 | The Journal of Immunology | Oxford Academic The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.

The latest issue of The JI is now online! Read cutting edge research, brief reviews, and more.

🔗 ow.ly/RMa250XA7Ce

#ReadTheJI #Immunology

This #CuttingEdge article reports that neutralizing FLT3L may effectively treat Sjögren’s and other FLT3L-associated autoimmune diseases. Read all about in The JI: ow.ly/u3lj50XyhWR.

Data suggest that S. mansoni may have evolved to manipulate TRPV1+ neuron activation as a countermeasure to limit IL-17-mediated inflammation, facilitating systemic dissemination and chronic parasitism. Read more: ow.ly/3zz250XxJKa .

Clonally expanded IgG, but not IgA, antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections The Editors have selected this article as a highlight of the issue.

New data reveals the complex relationship between bone marrow antibody secreting repertoires, mucosal humoral immune responses, and B cell receptor antigen specificity during #influenza infection. Read more in this #TopRead article: ow.ly/3INy50Xt1vV.

Eomesodermin defines uterine NK cells crucial for pregnancy success in mice Abstract. Uterine natural killer cells have been thought to be critical for reproductive success, and their developmental origins remain unclear. Here, we

In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: ow.ly/jA6550XsYGs

The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.

Role of companion dogs in cancer immunotherapy development Abstract. Rodent models for evaluating new cancer immunotherapies often fail to fully recapitulate the complexity of immune interactions that occur in canc

Learn how canine cancer models are evaluating new immunotherapies for osteosarcoma, glioma, non-Hodgkin lymphoma, melanoma, uroepithelial cancer, and head and neck cancers in humans in The JI’s special collection on non-traditional animal models: ow.ly/6FRH50XmtjP.

Immunological aspects of naturally occurring model of hepatitis B virus (HBV) infection, hepatitis B, and HBV-associated hepatocellular carcinoma in the American woodchuck Marmota monax Abstract. Infection of eastern North American woodchucks (Marmota monax) with woodchuck hepatitis virus (WHV) represents the most valuable immunopathogenic

Woodchucks are naturally affected by Woodchuck Hepatitis Virus, with disease progression very similar to hepatitis B in people. This review in the special collection on nontraditional animal models discusses the huge impact of this animal model.

🔗 ow.ly/EQ3r50Xmt9l.

Contributions of large and agricultural animal models to immunology Abstract. While studies with laboratory rodent models have defined molecular and cellular components of the human immune system, experiments in these small

As part of the special collection on non-traditional animal models, researchers discuss how understanding immunity in a range of large animals can expand awareness of immunological processes critical for the maintenance of human health. Learn more: ow.ly/bCtV50Xmt0s.

Zombie Ants, Spider Bait, and a Sneaky Burrowing Worm: The 6 Spookiest Science Discoveries of the Past Year The natural world is full of discoveries that feel straight out of a Tim Burton fever dream.

#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3.

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Volume 214 Issue 10 | The Journal of Immunology | Oxford Academic The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.

A treat for you this Halloween: the October edition of The Journal of Immunology is online! Featuring a special collection titled. “Beyond the Mouse: Nontraditional Animal Models in Immunology” you don’t want to miss this one. Explore it all: ow.ly/jmK850Xj1K0

Glucocorticoid-induced Pneumocystis pneumonia mice developed immune reconstitution inflammatory syndrome after glucocorticoid withdrawal Abstract. Mortality from Pneumocystis pneumonia (PCP) continues to increase among non-human immunodeficiency virus (HIV) patients. Previous studies have re

Mortality from Pneumocystis #pneumonia (PCP) continues to increase among non-HIV patients. A new study looks at the role of withdrawing glucocorticoid in disease progression to better understand disease progression. Read more in The JI: ow.ly/EXrx50Xj1CR.

Immune abnormalities in AD skin with corresponding therapeutics approved, under investigation, or unsuccessful for the treatment of AD. Eos, eosinophil.

This #BriefReview discusses how molecular and blood profiling led to a therapeutic revolution for #AtopicDermatitis and highlights how this translational approach is being applied to advancing the therapeutic pipeline of #alopecia areata. Explore more: ow.ly/1kht50Xj1s5

Data establish c-di-AMP as a key PAMP of B. burgdorferi, the causative agent of #lymedisease which elicits a type I interferon response that can lead to the development of Lyme arthritis, for which a PAMP was previously unidentified. Read more online: ow.ly/jWcl50XesPS.

Don't delay! Submit your abstract for IMMUNOLOGY2026™ before 6 pm today.

Changes in macrophage polarization in LT mice. (A–D) Investigation using flow cytometry of total macrophages, M1 macrophages, and the ratio of M1 macrophages in each mouse lung tissue. (E) RT-qPCR examination of the expression levels of M1 macrophage markers (iNOS, IL-1β, and IL-6) and M2 macrophage markers (Arg1, Ym1, and Fizz) in mouse lung tissues.

New data identified miR-124-3p as a critical regulator of macrophage polarization and acute lung injury (ALI) pathophysiology, providing a potential therapeutic target for managing ALI in lung transplant recipients. Learn more: ow.ly/XsVv50XesKz.

Sex-dependent influence of LMAN1 on allergen-induced airway hyperresponsiveness Abstract. Allergic asthma is a chronic inflammatory disease of the airways characterized by a type 2-high adaptive immune response towards common aeroantig

Researchers investigated the role of lectin mannose-binding 1 (LMAN1) in house dust mite induced allergic asthma and found that the loss of LMAN1 led to opposing effects on airway hyperresponsiveness dependent on the sex of mice. Learn more: ow.ly/BZ0750Xb7vs.

Schema of the mechanism of action of HMGB1. HMGB1 inhibits the phosphorylation of the JAK1/STAT3 pathway downstream of IFN-γ by binding RAGE, thereby inhibiting the expression of PD-L1. IRF, Interferon Regulatory Factors.

Data showed that high-mobility group protein B1 (HMGB1) inhibited IFN-gamma induced PD-L1 expression, enhancing the antitumor effects of T cells and confirming the role of HMGB1 as a prognostic indicator for #lungcancer treated with CAR-T cells. Read more: ow.ly/lZZG50Xb7mk.

When observing wild-type Raji and Jurkat cells following co-culture in the absence of cognate MHC and TCR or superantigen, only 'finger-like' projections were observed at the cell-cell interface. Find the research behind September’s cover image online: ow.ly/NOkn50X6mnH

The role of VISTA engagement in limiting neutrophil-mediated inflammation The Editors have selected this article as a highlight of the issue.

Targeting the immune checkpoint inhibitory receptor VISTA improved disease severity in a mouse model of neutrophil-mediated arthritis. Researchers investigate the novel therapeutic opportunity for targeting VISTA in this September #TopRead article: ow.ly/iueJ50X6mlo

YouTube video by The American Association of Immunologists (AAI) Join us for IMMUNOLOGY2026™

Get ready for #IMMUNOLOGY2026™! We're heading to the vibrant city of Boston, MA. Prepare for groundbreaking science, incredible networking, and an unforgettable experience. Don't miss your chance to be part of the #immunology community! Learn more: immunology2026.aai.org/abstracts.

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases Abstract. Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor α-chain (CD2

Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.

Volume 214 Issue 9 | The Journal of Immunology | Oxford Academic The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.

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Less than two weeks left to submit your #IMMUNOLOGY2026™ abstract! Get your research seen on a global stage in Boston, MA and network with your peers. Submit now: immunology2026.aai.org/abstracts.