The Journal of Immunology

The evolving landscape of human and clinical immunology: challenges and opportunities for The JI “I like to think that when Medawar and his colleagues showed that immunological tolerance could be produced experimentally the new immunology was born. Thi

In their editorial for the special collection “Human and Clinical Immunology: An Evolving Landscape,” Dr. Roshini Abraham and Dr. Gerald Morris discuss the current pivotal moment of clinical immunology and the benefits of publishing in #TheJI. Read more: ow.ly/xB4Y50Wzn4Y

🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025.

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#AAIRESTORE

Apply today to participate in the AAI Peer-Review Mentorship Program! This program is designed to provide mentorship from seasoned professionals to develop your skills as a peer reviewer of manuscripts submitted to AAI journals. Learn more: ow.ly/qLyn50WuPxA.

In his lecture on “The Generation and Modification of Lymphocyte Antigen Receptor Genes,” Eugene Oltz, @ohiostatemed.bsky.social, described how chromatin accessibility controls where V(D)J recombination occurs during immune cell development. #AAIcourses

#ICYMI: The JI featured a special collection of articles curated by guest editor Patricia Gearhart, highlighting the impact of aging on the immune system with insights into the immunological effects of aging at the cellular level. Learn more: ow.ly/WwZn50WuPuA.

Fish requires FasL to facilitate CD8+ T-cell function and antimicrobial immunity Abstract. Although bony fish have CD8+ T cells, the mechanisms by which these early-evolved cytotoxic cells combat intracellular pathogens remain unclear.

#ICYMI: When studying Nile tilapia as a model, researchers determined that CD8+ T cells reshaped the FasL-dependent strategy throughout evolution, thereby enhancing the precision and specificity of adaptive immunity. Learn more: ow.ly/RPqF50Wslhz.

Gene-specific regulation of inflammation via TLR-induced chromatin modifications Abstract. This Pillars of Immunology article revisits the landmark 2007 study by Foster, Hargreaves, and Medzhitov—the first to uncover the mechanistic bas

The June issue’s Pillars of Immunology Commentary revisits the landmark 2007 paper by Foster, Hargreaves, and Medzhitov, which was the first to uncover the mechanistic basis of memory in the innate immune system. Read it in The JI: ow.ly/NxUU50WslaC.

Cryptococcosis, tuberculosis, and a kidney cancer fail to fit the atherosclerosis paradigm for foam cell lipid content Abstract. Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation of diverse origin. The long-standing paradigm that foa

Foam cells are dysfunctional, lipid-laden macrophages. Data indicate that the events underlying foam cell formation are disease- and microenvironment-specific, opening new avenues for disease-specific biomedical research. Learn more: ow.ly/Ah0k50WlLiQ.

Serum carcinoembryonic antigen levels as a predictive biomarker for cytokine-induced killer cell immunotherapy in patients with colorectal cancer Abstract. Cytokine-induced killer (CIK) cells, as an adoptive immunotherapy, are effective at treating colorectal cancer (CRC). However, whether an individ

#ICYMI: Cytokine-induced killer (CIK) cell therapy improved both progression-free and overall survival in patients with #colorectalcancer. CEA serum levels were identified as a biomarker to predict which patients will respond to CIK therapy. Learn more: academic.oup.com/jimmunol/art... #immunosky

Hippo-YAP pathway regulates antimicrobial immune response in obscure puffer Takifugu obscurus Abstract. The Hippo signaling pathway plays an important role in regulating host immune responses. However, few studies have explored its role in fish. The

The Hippo signaling pathway is important in regulating host immune responses, but have you thought about its role in fish? Scientists revealed the mechanism of the Hippo pathway in the antimicrobial immunity of a pufferfish, Takifugu obscurus. Read now: academic.oup.com/jimmunol/art... #immunosky

ERAP1-dependent extreme antigen processing efficacy can govern MHC class I expression hierarchy Abstract. Peptide presentation by major histocompatibility complex (MHC) class I molecules enables CD8+ T lymphocytes to monitor the intracellular proteome

#ICYMI: Researchers shared the development of an assay for quantitative assessment by flow cytometry of selective inhibitor effects on peptide trimming, both in the endogenous MHC-I processing pathway and in cross-presentation. Learn more in The JI: academic.oup.com/jimmunol/art...

Incredibly excited to share my final project from Monash which was recently published in @jimmunol.bsky.social! Together with Jesse Mulder from the Robinson Group @robinsonmj.bsky.social, we found a role for IL-21 in allergy responses by promoting type 2 memory B cell formation. Check it out !👇🏼

In a #CuttingEdge article, researchers identified an in-del generated novel neoepitope that elicited in vivo tumor control in models of prophylaxis and therapy. CD8 T cells elicited by this neoepitope showed notably less exhaustion. Learn more: academic.oup.com/jimmunol/art....

Researchers have described key events in the pulmonary anti-Influenza A (IAV) response of pigs, which open new avenues for developing IAV vaccines and therapies, and enable the better use of pigs as a model for human IAV infection and immunity. Learn more: ow.ly/xjnl50WlNLa

Transcriptional and chromatin accessibility landscapes of hematopoiesis in a mouse model of breast cancer Abstract. Increased myeloid lineage production, termed myeloid skewing, leading to decreased tumor immunity, is a hallmark of aberrant hematopoiesis associ

Researchers characterized the transcriptional and chromatin accessibility landscapes of bone marrow and splenic hematopoietic progenitors in breast cancer to understand the hematopoietic consequences of #cancer. Read more: ow.ly/gfEZ50WlLzk.

ICOS+ CD4+ T cells promote antitumor immunity through Akt/STAT1/T-bet axis in MSS/pMMR colorectal cancer Abstract. Inducible Co-Stimulator (ICOS), as a T-cell–specific costimulatory receptor that enhances T-cell responses to foreign antigens, plays a crucial r

Data revealed that inducible co-stimulator (ICOS) mediates antitumor immunity by promoting the secretion of cancer-suppressive cytokines, suggesting that activation of ICOS may be a potential therapeutic strategy for #colorectalcancer. Read more: ow.ly/vp4e50WlLvu.

A novel TOX-nanoluciferase reporter mouse for exploring modulators of T cell exhaustion The Editors have selected this article as a highlight of the issue.

Another #TopRead developed a novel TOX-nanoluciferase-based reporter system that can be used to monitor TOX expression and facilitate the screening of molecules that modulate cytotoxic T-cell exhaustion. Learn more: ow.ly/O9oW50WijyF.

Galectin-3 regulates erythropoiesis and enhances the immunoregulatory properties of CD71+ erythroid cells across developmental stages The Editors have selected this article as a highlight of the issue.

June #TopRead from @ualberta.bsky.social and @wchriuofa.bsky.social found distinct gene expression profiles in CD71+ erythroid cells at various developmental stages, suggesting a critical role for Gal-3 in modulating erythropoiesis and enhancing immunoregulation. Read more: ow.ly/L8uv50WiiFm.

Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity The Editors have selected this article as a highlight of the issue.

A June #TopRead identified different subtypes of neutrophils in #tuberculosis (TB) patients, indicating that neutrophils might be promising targets for TB host-directed therapy. Learn more: ow.ly/gBgR50WiiCr.

The immunopathogenesis of SARS-CoV-2 infection: Overview of lessons learned in the first 5 years Abstract. This review provides a broad overview of lessons learned in the five years since COVID-19 was identified. It is a bimodal disease, starting with

Dr. Otto O. Yang, Professor @UCLA, provides a review of lessons learned in the five years since #COVID19 was identified. Read what research has revealed and what remains to be investigated: ow.ly/XQo950WiiBT.

Volume 214 Issue 6 | The Journal of Immunology | Oxford Academic The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.

The June issue of The JI is online now! Find cutting-edge research, reviews, and commentaries on your favorite immunology topics. Read everything now: ow.ly/cVNx50WiiAe

A public health graphic titled "FACT:" states that the MMR vaccine does not cause autism. A syringe and a vaccine vial are visible on a yellow background. The text explains that the myth is based on a discredited, falsified study, and many other studies have found no link between the MMR vaccine and autism.

In the US, it is rare to get a #vaccine with #thimerosal. It has been completely removed from childhood vaccines and few #flu vaccines include it. Numerous studies have shown that there is no link between thimerosal and #autism.

Can autoimmune disease be cured by deep CD19+ cell depletion? Abstract. Therapeutic B cell depletion with monoclonal antibodies targeting CD20 forced a rethink about the pathogenic role of B cells and plasma cells in

A Translating Immunology article re-evaluates B cell depletion strategies, providing an alternative explanation for why CD19 depletion may be effective at achieving complete and durable remission in autoantibody-positive autoimmune diseases. Read more: ow.ly/3XFy50WbZkr

Did you present research at #IMMUNOLOGY2025™? If so, The JI invites you to submit manuscripts based on your abstract for a special collection “Highlights of IMMUNOLOGY2025”! Expand your conference presentation and widely share your findings! Learn more: ow.ly/1Cj550WbZcv

MHC II–restricted presentation of soluble antigen by naïve B cells is impaired upon engagement with membrane-associated antigen: A potential mechanism to mitigate autoreactivity Abstract. T cell tolerance to self can prevent self-reactive B cells from mounting effective autoimmune responses by limiting their available help. However

Excited to share our latest publication in the
@jimmunol.bsky.social! 👇🧵

@thedohertyinst.bsky.social

academic.oup.com/jimmunol/art...

On the left is a headshot of Gail A. Bishop, Ph.D., Editor-in-Chief of The Journal of Immunology. On the right, the title reads "The negative impacts of 'impact'". Below it, a description states: "Recent articles in several scientific journals highlight the troubling upsurge in retractions and data manipulation impacting the integrity of peer-reviewed scientific literature. A variety of proposals have been advanced to counter this trend. The majority involve increased detection efforts, mostly by scientific publishers, to ferret out invalid data whenever it has appeared." A "READ MORE" button with a double arrow icon is present. At the bottom, the logos for "The Journal of Immunology" and "American Association of Immunologists" are displayed.

An editorial by Editor-in-Chief, Gail Bishop, Ph.D., discusses the negative pressures that early-career scientists face to publish their work in journals with high impact factors, both to achieve career metrics and to support grant applications.

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Accurate enumeration of pathogen-specific and virtual memory CD8 T cells after infection Abstract. Establishing the magnitude and kinetics of polyclonal Ag-specific CD8 T-cell responses, in addition to their functional fitness, is critical for

Data shows that defining the magnitude and kinetics of an Ag-specific CD8 T-cell response requires distinguishing pathogen-induced effector and memory CD8 T cells from Tvm cells to improve the resolution of studies understanding CD8 T cells. Read more: ow.ly/M6PX50W9ZJx.

Impact of CD4+ T cell and TCR repertoires on SARS-CoV-2-Specific antibody responses in PLWH following COVID-19 vaccination Abstract. In people living with human immunodeficiency virus (HIV, PLWH), the coronavirus disease 2019 (COVID-19) vaccine often results in a limited humora

#ICYMI: Data showed that the SARS-CoV-2-specific antibody response in #PLWH was not solely determined by current CD4+ T cell counts; immune reconstitution and TCR profiles of CD4+ T cells also played significant roles. Learn more by reading The JI: ow.ly/je8g50W9ZCl

Immunological biomarkers of aging Abstract. The immune system has long been recognized for its critical role in the elimination of pathogens and the development of autoimmune diseases, but

A review in the #aging special collection by Dr. Fei Wu et al used changes in proinflammatory cytokines to develop an inflammatory clock called iAge. These biomarkers can be used to track disease and discover successful interventions. Read more: ow.ly/Rsxk50W6fOb

🔬 Whether you're a student or a seasoned scientist, our Introductory and Advanced Immunology Courses offer invaluable learning experiences. Learn from world-renowned experts and expand your knowledge of the immune system. Register now: ow.ly/SUJc50W8uOw.